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MOUSE:REL1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Rln1 (synonyms: Rln, Rlx)
Protein Name(s) Prorelaxin 1

Relaxin B chain Relaxin A chain

External Links
UniProt P47932
EMBL Z27088
CCDS CCDS29733.1
PIR S48082
UniGene Mm.5033
ProteinModelPortal P47932
SMR P47932
STRING 10090.ENSMUSP00000043376
PhosphoSite P47932
PRIDE P47932
MGI MGI:97931
eggNOG NOG40989
HOGENOM HOG000236342
HOVERGEN HBG003234
InParanoid P47932
PhylomeDB P47932
PRO PR:P47932
Proteomes UP000000589
CleanEx MM_RLN1
Genevestigator P47932
GO GO:0005576
GO:0005102
GO:0048589
GO:0060736
GO:0010749
InterPro IPR016179
IPR022421
Pfam PF00049
PRINTS PR02004
SMART SM00078
SUPFAM SSF56994

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007283

spermatogenesis

PMID:12861045[1]

ECO:0000315

P

In figure 2 E,F,G &H, the authors demonstrate that there is a reduction in mature spermatozoa formation in seminiferous tubules of homozygous relaxin knockout mice.

complete
CACAO 2083

GO:0042981

regulation of apoptosis

PMID:12861045[1]

ECO:0000315

P

In table 2, the authors demonstrate that homozygous relaxin knockout mice had more Bax and caspase-9 positive cells in the testis.

complete
CACAO 2084

GO:0060443

mammary gland morphogenesis

PMID:9886856[2]

ECO:0000315

P

In table 1, the authors demonstrate that homozygous relaxin knockout mice displayed altered mammary gland morphogenesis.

complete
CACAO 2091

GO:0060618

nipple development

PMID:9886856[2]

ECO:0000315

P

In figure 6, the authors demonstrate that homozygous relaxin knockout mice displayed abnormal nipple development after parturition.

complete
CACAO 2092

involved_in

GO:0060443

mammary gland morphogenesis

PMID:9886856[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

PMID:12861045[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

PMID:12861045[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060618

nipple development

PMID:9886856[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060736

prostate gland growth

PMID:12861045[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668458

P

occurs_in:(EMAPA:32290)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048589

developmental growth

PMID:12861045[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668458

P

occurs_in:(EMAPA:19180)|occurs_in:(EMAPA:19290)|occurs_in:(EMAPA:17972)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3579

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042127

regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3579

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010749

regulation of nitric oxide mediated signal transduction

PMID:19073841[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2668458

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010749

regulation of nitric oxide mediated signal transduction

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01347

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007188

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P01347

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:8216305[4]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(EMAPA:35187)

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016179
InterPro:IPR022421

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016179
InterPro:IPR022421

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Samuel, CS et al. (2003) Relaxin is a key mediator of prostate growth and male reproductive tract development. Lab. Invest. 83 1055-67 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Zhao, L et al. (1999) Mice without a functional relaxin gene are unable to deliver milk to their pups. Endocrinology 140 445-53 PubMed GONUTS page
  3. Mookerjee, I et al. (2009) Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2. FASEB J. 23 1219-29 PubMed GONUTS page
  4. Büllesbach, EE & Schwabe, C (1993) Mouse relaxin: synthesis and biological activity of the first relaxin with an unusual crosslinking pattern. Biochem. Biophys. Res. Commun. 196 311-9 PubMed GONUTS page