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MOUSE:REL1
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Rln1 (synonyms: Rln, Rlx) | |
Protein Name(s) | Prorelaxin 1
Relaxin B chain Relaxin A chain | |
External Links | ||
UniProt | P47932 | |
EMBL | Z27088 | |
CCDS | CCDS29733.1 | |
PIR | S48082 | |
UniGene | Mm.5033 | |
ProteinModelPortal | P47932 | |
SMR | P47932 | |
STRING | 10090.ENSMUSP00000043376 | |
PhosphoSite | P47932 | |
PRIDE | P47932 | |
MGI | MGI:97931 | |
eggNOG | NOG40989 | |
HOGENOM | HOG000236342 | |
HOVERGEN | HBG003234 | |
InParanoid | P47932 | |
PhylomeDB | P47932 | |
PRO | PR:P47932 | |
Proteomes | UP000000589 | |
CleanEx | MM_RLN1 | |
Genevestigator | P47932 | |
GO | GO:0005576 GO:0005102 GO:0048589 GO:0060736 GO:0010749 | |
InterPro | IPR016179 IPR022421 | |
Pfam | PF00049 | |
PRINTS | PR02004 | |
SMART | SM00078 | |
SUPFAM | SSF56994 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0007283 |
spermatogenesis |
ECO:0000315 |
P |
In figure 2 E,F,G &H, the authors demonstrate that there is a reduction in mature spermatozoa formation in seminiferous tubules of homozygous relaxin knockout mice. |
complete | |||||
GO:0042981 |
regulation of apoptosis |
ECO:0000315 |
P |
In table 2, the authors demonstrate that homozygous relaxin knockout mice had more Bax and caspase-9 positive cells in the testis. |
complete | |||||
GO:0060443 |
mammary gland morphogenesis |
ECO:0000315 |
P |
In table 1, the authors demonstrate that homozygous relaxin knockout mice displayed altered mammary gland morphogenesis. |
complete | |||||
GO:0060618 |
nipple development |
ECO:0000315 |
P |
In figure 6, the authors demonstrate that homozygous relaxin knockout mice displayed abnormal nipple development after parturition. |
complete | |||||
involved_in |
GO:0060443 |
mammary gland morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060618 |
nipple development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060736 |
prostate gland growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668458 |
P |
occurs_in:(EMAPA:32290) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0048589 |
developmental growth |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668458 |
P |
occurs_in:(EMAPA:19180)|occurs_in:(EMAPA:19290)|occurs_in:(EMAPA:17972) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3579 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3579 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0010749 |
regulation of nitric oxide mediated signal transduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2668458 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0010749 |
regulation of nitric oxide mediated signal transduction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007188 |
adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_in:(EMAPA:35187) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0005179 |
hormone activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005179 |
hormone activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Samuel, CS et al. (2003) Relaxin is a key mediator of prostate growth and male reproductive tract development. Lab. Invest. 83 1055-67 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Zhao, L et al. (1999) Mice without a functional relaxin gene are unable to deliver milk to their pups. Endocrinology 140 445-53 PubMed GONUTS page
- ↑ Mookerjee, I et al. (2009) Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2. FASEB J. 23 1219-29 PubMed GONUTS page
- ↑ Büllesbach, EE & Schwabe, C (1993) Mouse relaxin: synthesis and biological activity of the first relaxin with an unusual crosslinking pattern. Biochem. Biophys. Res. Commun. 196 311-9 PubMed GONUTS page
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