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HUMAN:RXFP1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RXFP1 (synonyms: LGR7)
Protein Name(s) Relaxin receptor 1

Leucine-rich repeat-containing G-protein coupled receptor 7 Relaxin family peptide receptor 1

External Links
UniProt Q9HBX9
EMBL AF190500
AY899848
AY899849
AY899850
AK295040
AK300379
AC019341
AC107056
AC107219
AC108017
AC121161
AC125489
CH471056
BC112142
BC113617
CCDS CCDS43276.1
CCDS58929.1
CCDS58930.1
RefSeq NP_001240657.1
NP_001240658.1
NP_067647.2
UniGene Hs.591686
PDB 2JM4
2M7P
PDBsum 2JM4
2M7P
ProteinModelPortal Q9HBX9
SMR Q9HBX9
BioGrid 121891
IntAct Q9HBX9
MINT MINT-231156
STRING 9606.ENSP00000303248
BindingDB Q9HBX9
ChEMBL CHEMBL1293316
GuidetoPHARMACOLOGY 351
PhosphoSite Q9HBX9
DMDM 166209887
MaxQB Q9HBX9
PaxDb Q9HBX9
PRIDE Q9HBX9
DNASU 59350
Ensembl ENST00000307765
ENST00000343542
ENST00000470033
ENST00000471616
GeneID 59350
KEGG hsa:59350
UCSC uc003ipz.3
uc010iqm.3
uc010iqo.3
CTD 59350
GeneCards GC04P159236
H-InvDB HIX0024561
HGNC HGNC:19718
HPA HPA027067
MIM 606654
neXtProt NX_Q9HBX9
PharmGKB PA134868312
eggNOG COG4886
GeneTree ENSGT00760000119088
HOVERGEN HBG026354
InParanoid Q9HBX9
KO K04306
OMA TRPFKEM
PhylomeDB Q9HBX9
TreeFam TF326185
Reactome REACT_19327
REACT_21314
EvolutionaryTrace Q9HBX9
GeneWiki Relaxin/insulin-like_family_peptide_receptor_1
GenomeRNAi 59350
NextBio 35471982
PRO PR:Q9HBX9
Proteomes UP000005640
Bgee Q9HBX9
CleanEx HS_RXFP1
ExpressionAtlas Q9HBX9
Genevestigator Q9HBX9
GO GO:0016021
GO:0005886
GO:0004930
GO:0042562
GO:0046872
GO:0007188
GO:0030154
GO:0030198
GO:0060427
GO:0060658
GO:0007567
Gene3D 4.10.400.10
InterPro IPR000276
IPR017452
IPR023415
IPR002172
IPR001611
IPR003591
IPR000372
IPR008112
Pfam PF00001
PF00057
PF13855
PRINTS PR00237
PR01739
SMART SM00192
SM00369
SM00013
SUPFAM SSF57424
PROSITE PS50262
PS01209
PS50068
PS51450

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0009755

hormone-mediated signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0016650
PANTHER:PTN001224574
RGD:3007

P

Seeded From UniProt

complete

enables

GO:0008528

G protein-coupled peptide receptor activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001224574
RGD:3007

F

Seeded From UniProt

complete

involved_in

GO:0007190

activation of adenylate cyclase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96783
PANTHER:PTN001224574
RGD:3007

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2153463
MGI:MGI:96783
MGI:MGI:98849
PANTHER:PTN001224574
RGD:1302973
RGD:2632
UniProtKB:Q90674

P

Seeded From UniProt

complete

involved_in

GO:0007188

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2682211
PANTHER:PTN000687866

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003255
FB:FBgn0016650
MGI:MGI:96783
PANTHER:PTN001224574
RGD:3007
UniProtKB:O75473
UniProtKB:Q9BXB1

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000687866
RGD:1302973
UniProtKB:Q9HBX9

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

PMID:11809971[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0030819

positive regulation of cAMP biosynthetic process

PMID:16569707[3]

ECO:0000314

P

In figure 1, the authors demonstrate that human RXFP1 has a positive influence on cAMP production in the presence of its ligand.

complete
CACAO 1964

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR008112

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008112

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008112

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR017452

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-744887
Reactome:R-HSA-744886
Reactome:R-HSA-444838
Reactome:R-HSA-379044

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Hsu, SY et al. (2002) Activation of orphan receptors by the hormone relaxin. Science 295 671-4 PubMed GONUTS page
  3. ↑ Halls, ML et al. (2006) Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms. Mol. Pharmacol. 70 214-26 PubMed GONUTS page
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