User:Cthorstenson

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
unacceptable	HUMAN:PTBP1	2013-09-29 15:30:57 CDT	GO:2000279 negative regulation of DNA biosynthetic process (P)	PMID:23536791	ECO:0000314 direct assay evidence used in manual assertion	Figure 1c. Decrease in DNA synthesis when increase PTB expression.	challenge
acceptable	MOUSE:TMED2	2013-10-27 16:05:00 CDT	GO:0060716 labyrinthine layer blood vessel development (P)	PMID:20178780	ECO:0000315 mutant phenotype evidence used in manual assertion	Fig 2. Absence of the labyrinth layer in the mutant phenotype. More specifically as seen in Fig.2 D-F there is no invagination of the allantois into the chorion, which is necessary for the formation of the labyrinth layer, in the mutants like there is in the wild type.	challenge
acceptable	PHLPR:MPA5B	2013-10-27 16:27:51 CDT	GO:0004540 ribonuclease activity (F)	PMID:7729555	ECO:0000314 direct assay evidence used in manual assertion	Fig 3 shows mRNA is degraded by purified Phl p Vb	challenge
unacceptable	VIBCH:ZOT	2013-11-06 21:33:16 CST	GO:0005923 tight junction (C)	PMID:1730472	ECO:0000314 direct assay evidence used in manual assertion	Figure 2. When tissues were treated with a permeability marker and different strains of cholera, the strains producing the toxin (inferred from fig 1) showed increased permeability in the tight junctions	challenge
requireschanges	RAT:TBB2B	2013-11-10 16:05:31 CST	GO:0046785 microtubule polymerization (P)	PMID:19465910	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 3 and Figure 5. TBB2B mutants poorly produce competent heterodimers for microtubule polymerization.	challenge
unacceptable	RAT:TBB2B	2013-11-10 16:05:31 CST	GO:0001764 neuron migration (P)	PMID:19465910	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2. Tubb2b expression was knocked-down by 50% in embryonic cells. This resulted in the arrest of neuron migration.	challenge
unacceptable	RAT:Q9Z1X8	2013-11-10 16:43:56 CST	GO:0008285 negative regulation of cell proliferation (P)	PMID:9857061	ECO:0000314 direct assay evidence used in manual assertion	Figure 5. Expression of protein inhibited cell growth	challenge
requireschanges	RAT:Q9Z1X8	2013-11-10 16:43:56 CST	GO:0033267 axon part (C)	PMID:9857061	ECO:0000314 direct assay evidence used in manual assertion	Figure 4. High expression of protein in brain neural axon	challenge
unacceptable	RAT:Q9Z1X8	2013-11-10 16:43:56 CST	GO:0044444 cytoplasmic part (C)	PMID:9857061	ECO:0000314 direct assay evidence used in manual assertion	Figure 4. Majority of expression is seen in the cytoplasm.	challenge
acceptable	RAT:Q9Z1X8	2013-11-10 16:43:57 CST	GO:0032839 dendrite cytoplasm (C)	PMID:9857061	ECO:0000314 direct assay evidence used in manual assertion	Figure 4. NFB42 is cytoplasmic, showing high expression in dendrites in many parts of the brain.	challenge
unacceptable	MOUSE:TRAM2	2013-11-10 17:55:42 CST	GO:2000489 regulation of hepatic stellate cell activation (P)	PMID:14749390	ECO:0000314 direct assay evidence used in manual assertion	Figure 2. (and 1)TRAM2 is expressed in activated haptic stellate cells	challenge
requireschanges	MOUSE:TRAM2	2013-11-10 17:55:43 CST	GO:0032965 regulation of collagen biosynthetic process (P)	PMID:14749390	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 4 &5. Mutant TRAM2 inhibits collagen synthesis by hepatic stellate cells	challenge

acceptable:3
unacceptable:6
requires_changes:3
flagged:0

Annotations challenged by Cthorstenson

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
updatedbyinstructor	Atruchon, Team Hu Ville	RALSO:Q8XZS6	GO:0033320 - UDP-D-xylose biosynthetic process (P)	PMID:20118241	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 5 fixed by Roosheel
updatedbyinstructor	Sabrinamoisan, Team Go Pro	MOUSE:HYAS1	GO:0005737 - cytoplasm (C)	PMID:24057227	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
updatedbyinstructor	Sabrinamoisan, Team Go Pro	MOUSE:HYAS2	GO:0005737 - cytoplasm (C)	PMID:24057227	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
unacceptable	Djgulizia, Team Texas Aggies	MOUSE:AMPD2	GO:0097018 - renal albumin absorption (P)	PMID:22212473	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 3
updatedbyinstructor	Djgulizia, Team Texas Aggies	MOUSE:SWP70	GO:0060754 - positive regulation of mast cell chemotaxis (P)	PMID:15542837	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 1

0 annotations fixed by Cthorstenson

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