MOUSE:HYAS2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Has2
Protein Name(s)	Hyaluronan synthase 2 Hyaluronate synthase 2 Hyaluronic acid synthase 2 HA synthase 2
External Links
UniProt	P70312
EMBL	U52524 U69695 AK079729 CH466545 BC080281 U53222
CCDS	CCDS27480.1
RefSeq	NP_032242.3
UniGene	Mm.5148
ProteinModelPortal	P70312
STRING	10090.ENSMUSP00000062212
CAZy	GT2
iPTMnet	P70312
PhosphoSite	P70312
PaxDb	P70312
PRIDE	P70312
Ensembl	ENSMUST00000050544
GeneID	15117
KEGG	mmu:15117
UCSC	uc007vsl.2
CTD	3037
MGI	MGI:107821
eggNOG	KOG2571 COG1215
GeneTree	ENSGT00390000010337
HOGENOM	HOG000112847
HOVERGEN	HBG000189
InParanoid	P70312
KO	K00752
OMA	TAYIMGY
OrthoDB	EOG77WWBZ
TreeFam	TF332506
BRENDA	2.4.1.212
UniPathway	UPA00341
PRO	PR:P70312
Proteomes	UP000000589
Bgee	P70312
CleanEx	MM_HAS2
Genevisible	P70312
GO	GO:0005737 GO:0005887 GO:0050501 GO:0036302 GO:0060349 GO:0071498 GO:0071347 GO:0036120 GO:0071356 GO:0090500 GO:0044849 GO:0085029 GO:0045226 GO:0030213 GO:0030212 GO:0001822 GO:0030335 GO:0008284 GO:1900127 GO:0051549 GO:0010838 GO:1900625 GO:0014911 GO:1900026 GO:0035810 GO:0070295 GO:0001570
Gene3D	3.90.550.10
InterPro	IPR001173 IPR026107 IPR028371 IPR029044
PANTHER	PTHR22913 PTHR22913:SF7
Pfam	PF00535
SUPFAM	SSF53448

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005737	cytoplasm	PMID:24057227^[1]	ECO:0000314			C		Figures 1,2,3,4	complete CACAO 8629
	GO:0031410	cytoplasmic vesicle	PMID:24057227^[1]	ECO:0000314			C		Figure 6	complete CACAO 9080
part_of	GO:0005737	cytoplasm	PMID:24057227^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090500	endocardial cushion to mesenchymal transition	PMID:10930438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0085029	extracellular matrix assembly	PMID:10455188^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070295	renal water absorption	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	P		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	PMID:10455188^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	F		Seeded From UniProt	complete
involved_in	GO:0045226	extracellular polysaccharide biosynthetic process	PMID:10455188^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036302	atrioventricular canal development	PMID:10930438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035810	positive regulation of urine volume	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	P		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	PMID:10930438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35776	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	PMID:10930438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0085029	extracellular matrix assembly	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809	P		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809 RGD:2781 UniProtKB:O00219 UniProtKB:Q92819	F		Seeded From UniProt	complete
involved_in	GO:0045226	extracellular polysaccharide biosynthetic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809	P		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106590 MGI:MGI:107821 MGI:MGI:109599 PANTHER:PTN000530809 RGD:2781 UniProtKB:O00219 UniProtKB:Q92819	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000530809 UniProtKB:Q92819	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901201	regulation of extracellular matrix assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2781	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900625	positive regulation of monocyte aggregation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92819	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900127	positive regulation of hyaluronan biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2781	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2781	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060349	bone morphogenesis	PMID:21246657^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176070,MGI:MGI:4360705	P	has_participant:(EMAPA:18514)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051549	positive regulation of keratinocyte migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2781	P		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92819	F		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2781	F		Seeded From UniProt	complete
part_of	GO:0044853	plasma membrane raft	PMID:22383528^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92819	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036120	cellular response to platelet-derived growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92819	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92819	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92819	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030212	hyaluronan metabolic process	PMID:21246657^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176070,MGI:MGI:4360705	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2781	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010838	positive regulation of keratinocyte proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2781	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92819	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92819	C		Seeded From UniProt	complete
involved_in	GO:1901201	regulation of extracellular matrix assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:1900127	positive regulation of hyaluronan biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0070295	renal water absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0051549	positive regulation of keratinocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	F		Seeded From UniProt	complete
involved_in	GO:0044849	estrous cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0035810	positive regulation of urine volume	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0010838	positive regulation of keratinocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35776 ensembl:ENSRNOP00000006517	P		Seeded From UniProt	complete
involved_in	GO:1900625	positive regulation of monocyte aggregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92819 ensembl:ENSP00000306991	P		Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92819 ensembl:ENSP00000306991	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92819 ensembl:ENSP00000306991	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92819 ensembl:ENSP00000306991	P		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92819 ensembl:ENSP00000306991	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92819 ensembl:ENSP00000306991	F		Seeded From UniProt	complete
involved_in	GO:0036120	cellular response to platelet-derived growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92819 ensembl:ENSP00000306991	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92819 ensembl:ENSP00000306991	P		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92819 ensembl:ENSP00000306991	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92819 ensembl:ENSP00000306991	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92819 ensembl:ENSP00000306991	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028371	C		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028371	P		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028371	F		Seeded From UniProt	complete
enables	GO:0050501	hyaluronan synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.4.1.212	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0016757	transferase activity, transferring glycosyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0328	F		Seeded From UniProt	complete
involved_in	GO:0030213	hyaluronan biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00341	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Törrönen, K et al. (2014) Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes. Histochem. Cell Biol. 141 17-31 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Camenisch, TD et al. (2000) Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J. Clin. Invest. 106 349-60 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Itano, N et al. (1999) Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. J. Biol. Chem. 274 25085-92 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Moffatt, P et al. (2011) Hyaluronan production by means of Has2 gene expression in chondrocytes is essential for long bone development. Dev. Dyn. 240 404-12 PubMed GONUTS page
↑ Qin, J et al. (2012) Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt. J. Biol. Chem. 287 13620-32 PubMed GONUTS page

[PMID:24057227-1] 1.0 ^1.1 ^1.2 Törrönen, K et al. (2014) Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes. Histochem. Cell Biol. 141 17-31 PubMed GONUTS page

[PMID:10930438-2] 2.0 ^2.1 ^2.2 ^2.3 Camenisch, TD et al. (2000) Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J. Clin. Invest. 106 349-60 PubMed GONUTS page

[PMID:10455188-3] 3.0 ^3.1 ^3.2 Itano, N et al. (1999) Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. J. Biol. Chem. 274 25085-92 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21246657-5] 5.0 ^5.1 Moffatt, P et al. (2011) Hyaluronan production by means of Has2 gene expression in chondrocytes is essential for long bone development. Dev. Dyn. 240 404-12 PubMed GONUTS page

[PMID:22383528-6] Qin, J et al. (2012) Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt. J. Biol. Chem. 287 13620-32 PubMed GONUTS page

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MOUSE:HYAS2

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