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MOUSE:SWP70
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Swap70 (synonyms: Kiaa0640) | |
| Protein Name(s) | Switch-associated protein 70
SWAP-70 | |
| External Links | ||
| UniProt | Q6A028 | |
| EMBL | AF053974 AK172990 AK146773 AK150621 AK163357 BC065136 | |
| CCDS | CCDS21744.1 | |
| RefSeq | NP_033328.3 | |
| UniGene | Mm.334144 | |
| ProteinModelPortal | Q6A028 | |
| SMR | Q6A028 | |
| BioGrid | 203593 | |
| IntAct | Q6A028 | |
| MINT | MINT-4105516 | |
| MaxQB | Q6A028 | |
| PaxDb | Q6A028 | |
| PRIDE | Q6A028 | |
| Ensembl | ENSMUST00000033325 | |
| GeneID | 20947 | |
| KEGG | mmu:20947 | |
| UCSC | uc009jfb.2 | |
| CTD | 23075 | |
| MGI | MGI:1298390 | |
| eggNOG | NOG117655 | |
| GeneTree | ENSGT00390000005512 | |
| HOGENOM | HOG000285974 | |
| HOVERGEN | HBG053201 | |
| InParanoid | Q6A028 | |
| OMA | RQTVSMA | |
| OrthoDB | EOG7H1JK5 | |
| PhylomeDB | Q6A028 | |
| TreeFam | TF333160 | |
| ChiTaRS | Swap70 | |
| NextBio | 299899 | |
| PRO | PR:Q6A028 | |
| Proteomes | UP000000589 | |
| Bgee | Q6A028 | |
| CleanEx | MM_SWAP70 | |
| Genevestigator | Q6A028 | |
| GO | GO:0005737 GO:0030027 GO:0005634 GO:0005886 GO:0005524 GO:0003677 GO:0045190 GO:0016444 | |
| Gene3D | 2.30.29.30 | |
| InterPro | IPR001849 IPR011993 | |
| Pfam | PF00169 | |
| SMART | SM00233 | |
| PROSITE | PS50003 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0030835 |
negative regulation of actin filament depolymerization |
ECO:0000314 |
P |
1E shows that increased concentrations of SWAP-70 lead to delays in actin depolymerization |
complete | |||||
| GO:0051017 |
actin filament bundle assembly |
ECO:0000314 |
P |
Fig 3 shows that SWAP-70 bundles actin filaments together in both parallel and anti-parallel manners |
complete | |||||
| GO:0032233 |
positive regulation of actin filament bundle assembly |
ECO:0000315 |
P |
Figure 5, in vivo analysis displays that SWAP-70 -/- have signifiantly fewer actin filament bundles. |
complete | |||||
| GO:1902309 |
negative regulation of peptidyl-serine dephosphorylation |
ECO:0000315 |
P |
Figure 8 A-C shows that in SWAP-70 -/- mutants, the protein "cofilin-1" remains phosphorylated for a longer than in the WT. |
complete | |||||
| GO:0060754 |
positive regulation of mast cell chemotaxis |
ECO:0000315 |
P |
Figure 1, SWAP-70 KOs display reduced migration of bone marrow mast cells. |
complete | |||||
| GO:0008064 |
regulation of actin polymerization or depolymerization |
ECO:0000315 |
P |
Figure 2, SWAP-70 KOs exhibit altered regulation of f-actin filaments. |
complete | |||||
| GO:0032880 |
regulation of protein localization |
ECO:0000315 |
P |
Figure 3, SWAP-70 KOs display decreased localization of Rac1 and Rac2 to the cell periphery. |
complete | |||||
| GO:0007204 |
elevation of cytosolic calcium ion concentration |
ECO:0000315 |
P |
Figure 4, SWAP-70 KOs don't see the same rapid elevation in Ca2+ ions within the cell that a WT cell does after stimulation. |
complete | |||||
| GO:0033633 |
negative regulation of cell-cell adhesion mediated by integrin |
ECO:0000315 |
P |
Figure 7, SWAP-70 KOs adhere much more than the WT cells; this adhesion was found to be dependent on the integrin LFA-1. |
complete | |||||
|
involved_in |
GO:0033633 |
negative regulation of cell-cell adhesion mediated by integrin |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032880 |
regulation of protein localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008064 |
regulation of actin polymerization or depolymerization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060754 |
positive regulation of mast cell chemotaxis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902309 |
negative regulation of peptidyl-serine dephosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032233 |
positive regulation of actin filament bundle assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051017 |
actin filament bundle assembly |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030835 |
negative regulation of actin filament depolymerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000372947 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1298390 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045190 |
isotype switching |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016444 |
somatic cell DNA recombination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UH65 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030027 |
lamellipodium |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Chacón-Martínez, CA et al. (2013) The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics. J. Biol. Chem. 288 28687-703 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Sivalenka, RR & Jessberger, R (2004) SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration. Mol. Cell. Biol. 24 10277-88 PubMed GONUTS page
- ↑ 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Borggrefe, T et al. (1998) A B-cell-specific DNA recombination complex. J. Biol. Chem. 273 17025-35 PubMed GONUTS page
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