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RAT:TBB2B

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Tubb2b (synonyms: Tubb2a)
Protein Name(s) Tubulin beta-2B chain

T beta-15

External Links
UniProt Q3KRE8
EMBL X03369
BC105754
PIR A25113
RefSeq NP_001013908.2
UniGene Rn.37849
ProteinModelPortal Q3KRE8
SMR Q3KRE8
BioGrid 253414
IntAct Q3KRE8
MINT MINT-236031
STRING 10116.ENSRNOP00000023582
BindingDB Q3KRE8
PhosphoSite Q3KRE8
PaxDb Q3KRE8
PRIDE Q3KRE8
Ensembl ENSRNOT00000023582
GeneID 291081
KEGG rno:291081
UCSC RGD:1309427
CTD 347733
RGD 1309427
eggNOG COG5023
GeneTree ENSGT00760000119061
HOGENOM HOG000165710
HOVERGEN HBG000089
InParanoid Q3KRE8
KO K07375
OMA LERINXQ
OrthoDB EOG71ZP1H
PhylomeDB Q3KRE8
TreeFam TF300298
Reactome REACT_194781
REACT_198611
REACT_198830
REACT_199176
REACT_199245
REACT_229626
REACT_233852
REACT_244779
REACT_245819
REACT_250352
REACT_261180
REACT_262886
REACT_269621
REACT_270861
NextBio 632089
Proteomes UP000002494
ExpressionAtlas Q3KRE8
Genevestigator Q3KRE8
GO GO:0005737
GO:0005874
GO:0005634
GO:0005525
GO:0003924
GO:0005200
GO:0007017
GO:0001764
GO:0051258
Gene3D 1.10.287.600
3.30.1330.20
3.40.50.1440
InterPro IPR013838
IPR002453
IPR008280
IPR000217
IPR018316
IPR023123
IPR017975
IPR003008
PANTHER PTHR11588
Pfam PF00091
PF03953
PRINTS PR01163
PR01161
SMART SM00864
SM00865
SUPFAM SSF52490
SSF55307
PROSITE PS00227
PS00228

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0046785

microtubule polymerization

PMID:19465910[1]

ECO:0000315

P

Figure 3 and Figure 5. TBB2B mutants poorly produce competent heterodimers for microtubule polymerization.

complete
CACAO 9157

GO:0001764

neuron migration

PMID:19465910[1]

ECO:0000315

P

Figure 2. Tubb2b expression was knocked-down by 50% in embryonic cells. This resulted in the arrest of neuron migration.

complete
CACAO 9158

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9BVA1

F

Seeded From UniProt

complete

involved_in

GO:0007017

microtubule-based process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9BVA1

P

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9BVA1

C

Seeded From UniProt

complete

involved_in

GO:1902669

positive regulation of axon guidance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9BVA1

P

Seeded From UniProt

complete

involved_in

GO:0001764

neuron migration

PMID:19465910[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008150

biological_process

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005575

cellular_component

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003674

molecular_function

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007017

microtubule-based process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107812
MGI:MGI:107814
PANTHER:PTN000172598
UniProtKB:Q9BVA1
WB:WBGene00003175

P

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003887
FB:FBgn0003888
FB:FBgn0260639
MGI:MGI:107812
MGI:MGI:107814
MGI:MGI:1095406
PANTHER:PTN000172598
PomBase:SPBC800.05c
TAIR:locus:2076750
TAIR:locus:2166469
UniProtKB:P04350
UniProtKB:P07437
UniProtKB:P29511
UniProtKB:P68363
UniProtKB:P68366
UniProtKB:P68371
UniProtKB:Q13509
UniProtKB:Q13885
UniProtKB:Q3ZCM7
UniProtKB:Q71U36
UniProtKB:Q9BUF5
UniProtKB:Q9BVA1
UniProtKB:Q9NRH3
WB:WBGene00003175
dictyBase:DDB_G0287689

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010097
FB:FBgn0260639
MGI:MGI:101834
MGI:MGI:107813
MGI:MGI:107848
MGI:MGI:1891826
PANTHER:PTN000172598
PomBase:SPBC32F12.04
TAIR:locus:2076750
TAIR:locus:2166469
UniProtKB:P07437
UniProtKB:P23258
UniProtKB:Q9H4B7
WB:WBGene00006540

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010097
FB:FBgn0260639
PANTHER:PTN000172598

F

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003887
FB:FBgn0003888
MGI:MGI:107812
MGI:MGI:107814
PANTHER:PTN000172598
UniProtKB:A0A1D8PC97
UniProtKB:P18695
UniProtKB:P24633

F

Seeded From UniProt

complete

involved_in

GO:0001764

neuron migration

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001358285
RGD:1309427
UniProtKB:Q9BVA1

P

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000172598
RGD:628595
UniProtKB:P18695

P

Seeded From UniProt

complete

involved_in

GO:0000226

microtubule cytoskeleton organization

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000172598
UniProtKB:P29511

P

Seeded From UniProt

complete

part_of

GO:0098685

Schaffer collateral - CA1 synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CWF2
ensembl:ENSMUSP00000075178

C

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CWF2
ensembl:ENSMUSP00000075178

P

Seeded From UniProt

complete

involved_in

GO:1902669

positive regulation of axon guidance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BVA1
ensembl:ENSP00000259818

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BVA1
ensembl:ENSP00000259818

F

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BVA1
ensembl:ENSP00000259818

C

Seeded From UniProt

complete

involved_in

GO:0007017

microtubule-based process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BVA1
ensembl:ENSP00000259818

P

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BVA1
ensembl:ENSP00000259818

C

Seeded From UniProt

complete

involved_in

GO:0001764

neuron migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BVA1
ensembl:ENSP00000259818

P

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003008

F

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002453

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002453
InterPro:IPR017975

F

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000217
InterPro:IPR002453
InterPro:IPR017975

C

Seeded From UniProt

complete

involved_in

GO:0007017

microtubule-based process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000217
InterPro:IPR002453
InterPro:IPR017975

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Jaglin, XH et al. (2009) Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat. Genet. 41 746-52 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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