HUMAN:PTBP1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PTBP1 (synonyms: PTB)
Protein Name(s)	Polypyrimidine tract-binding protein 1 PTB 57 kDa RNA-binding protein PPTB-1 Heterogeneous nuclear ribonucleoprotein I hnRNP I
External Links
UniProt	P26599
EMBL	X62006 X65371 X65372 X60648 X66975 BT006819 AC006273 CH471242 BC002397 BC004383 BC013694
CCDS	CCDS32859.1 CCDS42456.1 CCDS45892.1
PIR	S23016
RefSeq	NP_002810.1 NP_114367.1 NP_114368.1
UniGene	Hs.172550
PDB	1QM9 1SJQ 1SJR 2AD9 2ADB 2ADC 2EVZ 3ZZY 3ZZZ
PDBsum	1QM9 1SJQ 1SJR 2AD9 2ADB 2ADC 2EVZ 3ZZY 3ZZZ
ProteinModelPortal	P26599
SMR	P26599
BioGrid	111697
IntAct	P26599
MINT	MINT-1348690
STRING	9606.ENSP00000349428
ChEMBL	CHEMBL1293230
PhosphoSite	P26599
DMDM	131528
SWISS-2DPAGE	P26599
MaxQB	P26599
PaxDb	P26599
PRIDE	P26599
DNASU	5725
Ensembl	ENST00000349038 ENST00000356948 ENST00000394601
GeneID	5725
KEGG	hsa:5725
UCSC	uc002lpp.2 uc002lpq.2 uc002lpr.2
CTD	5725
GeneCards	GC19P000797
H-InvDB	HIX0137476
HGNC	HGNC:9583
HPA	CAB013507
MIM	600693
neXtProt	NX_P26599
PharmGKB	PA33934
eggNOG	NOG263741
GeneTree	ENSGT00550000074508
HOGENOM	HOG000231699
HOVERGEN	HBG069548
InParanoid	P26599
KO	K13218
OMA	MSAQHAK
OrthoDB	EOG7V7691
PhylomeDB	P26599
TreeFam	TF319824
Reactome	REACT_125 REACT_467
ChiTaRS	PTBP1
EvolutionaryTrace	P26599
GeneWiki	PTBP1
GenomeRNAi	5725
NextBio	22252
PMAP-CutDB	P26599
PRO	PR:P26599
Proteomes	UP000005640
Bgee	P26599
CleanEx	HS_PTBP1
ExpressionAtlas	P26599
Genevestigator	P26599
GO	GO:0070062 GO:0016020 GO:0005730 GO:0005654 GO:0000166 GO:0044822 GO:0008187 GO:0036002 GO:0003723 GO:0000380 GO:0010467 GO:0006397 GO:0000398 GO:0048025 GO:0051148 GO:0033119 GO:0000381 GO:0008380
Gene3D	3.30.70.330
InterPro	IPR006536 IPR012677 IPR000504
Pfam	PF00076
SMART	SM00360
TIGRFAMs	TIGR01649
PROSITE	PS50102

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0035307	positive regulation of protein dephosphorylation	PMID:23853098^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q13469)	Seeded From UniProt	complete
involved_in	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	PMID:23853098^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0075522	IRES-dependent viral translational initiation	PMID:21518806^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0051148	negative regulation of muscle cell differentiation	PMID:21518792^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048025	negative regulation of mRNA splicing, via spliceosome	PMID:15009664^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
	GO:2000279	negative regulation of DNA biosynthetic process	PMID:23536791^[9]	ECO:0000314			P		Figure 1c. Decrease in DNA synthesis when increase PTB expression.	complete CACAO 8748
enables	GO:0036002	pre-mRNA binding	PMID:16260624^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033119	negative regulation of RNA splicing	PMID:18335065^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:21518792^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	PMID:16260624^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000504 InterPro:IPR035979	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006536 InterPro:IPR035000 InterPro:IPR035001	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006536	C		Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006536	P		Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	PMID:1906036^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008187	poly-pyrimidine tract binding	PMID:1906036^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	PMID:1906036^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:1641332^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:1641332^[13] Reactome:R-HSA-72160 Reactome:R-HSA-72143 Reactome:R-HSA-72139 Reactome:R-HSA-72130 Reactome:R-HSA-72127 Reactome:R-HSA-72124 Reactome:R-HSA-72107 Reactome:R-HSA-72103 Reactome:R-HSA-6803523 Reactome:R-HSA-156661	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:1906036^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016070	RNA metabolic process	Reactome:R-HSA-8953854	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
	GO:0000380	alternative mRNA splicing, via spliceosome	PMID:28404950^[14]	ECO:0000314			P		Controls all mechanisms of RNA splicing, which includes mRNA splicing through the splicesome, RNA splicing through transesterification mechanisms, and mRNA processing.	complete CACAO 12758
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:R-HSA-5654738	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	Reactome:R-HSA-72163	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0508	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kang, K et al. (2013) MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells. J. Biol. Chem. 288 25414-27 PubMed GONUTS page
↑ Kafasla, P et al. (2011) Activation of picornaviral IRESs by PTB shows differential dependence on each PTB RNA-binding domain. RNA 17 1120-31 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^5.0 ^5.1 Lin, JC & Tarn, WY (2011) RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing. J. Cell Biol. 193 509-20 PubMed GONUTS page
↑ Wang, J et al. (2004) Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. J. Neurochem. 88 1078-90 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ Lin, S et al. (2013) Polypyrimidine tract-binding protein induces p19(Ink4d) expression and inhibits the proliferation of H1299 cells. PLoS ONE 8 e58227 PubMed GONUTS page
↑ ^10.0 ^10.1 Lin, JC & Tarn, WY (2005) Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB. Mol. Cell. Biol. 25 10111-21 PubMed GONUTS page
↑ Robinson, F et al. (2008) Expression of human nPTB is limited by extreme suboptimal codon content. PLoS ONE 3 e1801 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Patton, JG et al. (1991) Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev. 5 1237-51 PubMed GONUTS page
↑ ^13.0 ^13.1 Ghetti, A et al. (1992) hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res. 20 3671-8 PubMed GONUTS page
↑ Wang, ZN et al. (2017) High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin. Oncotarget PubMed GONUTS page

[PMID:23853098-1] 1.0 ^1.1 Kang, K et al. (2013) MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells. J. Biol. Chem. 288 25414-27 PubMed GONUTS page

[PMID:21518806-2] Kafasla, P et al. (2011) Activation of picornaviral IRESs by PTB shows differential dependence on each PTB RNA-binding domain. RNA 17 1120-31 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:20458337-4] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:21518792-5] 5.0 ^5.1 Lin, JC & Tarn, WY (2011) RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing. J. Cell Biol. 193 509-20 PubMed GONUTS page

[PMID:15009664-6] Wang, J et al. (2004) Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. J. Neurochem. 88 1078-90 PubMed GONUTS page

[PMID:22681889-7] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:22658674-8] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:23536791-9] Lin, S et al. (2013) Polypyrimidine tract-binding protein induces p19(Ink4d) expression and inhibits the proliferation of H1299 cells. PLoS ONE 8 e58227 PubMed GONUTS page

[PMID:16260624-10] 10.0 ^10.1 Lin, JC & Tarn, WY (2005) Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB. Mol. Cell. Biol. 25 10111-21 PubMed GONUTS page

[PMID:18335065-11] Robinson, F et al. (2008) Expression of human nPTB is limited by extreme suboptimal codon content. PLoS ONE 3 e1801 PubMed GONUTS page

[PMID:1906036-12] 12.0 ^12.1 ^12.2 ^12.3 Patton, JG et al. (1991) Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev. 5 1237-51 PubMed GONUTS page

[PMID:1641332-13] 13.0 ^13.1 Ghetti, A et al. (1992) hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. Nucleic Acids Res. 20 3671-8 PubMed GONUTS page

[PMID:28404950-14] Wang, ZN et al. (2017) High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin. Oncotarget PubMed GONUTS page

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HUMAN:PTBP1

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