RAT:PDX1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Pdx1 (synonyms: Ipf1)
Protein Name(s)	Pancreas/duodenum homeobox protein 1 Insulin promoter factor 1 IPF-1 Islet/duodenum homeobox 1 IDX-1 Somatostatin-transactivating factor 1 STF-1
External Links
UniProt	P52947
EMBL	U04833 S67435
PIR	S42634
RefSeq	NP_074043.3
UniGene	Rn.54603
ProteinModelPortal	P52947
SMR	P52947
IntAct	P52947
MINT	MINT-1894530
PhosphoSite	P52947
Ensembl	ENSRNOT00000071942
GeneID	29535
KEGG	rno:29535
CTD	3651
RGD	62387
GeneTree	ENSGT00760000118940
HOVERGEN	HBG004525
InParanoid	P52947
KO	K07594
OMA	PPPCLYM
OrthoDB	EOG744TB4
PhylomeDB	P52947
Reactome	REACT_230812 REACT_244809
NextBio	609520
PRO	PR:P52947
Proteomes	UP000002494
Genevestigator	P52947
GO	GO:0005737 GO:0005829 GO:0005634 GO:0003682 GO:0001046 GO:0032403 GO:0046982 GO:0000978 GO:0043565 GO:0003700 GO:0008134 GO:0030154 GO:0007417 GO:0051594 GO:0048565 GO:0031017 GO:0042593 GO:0006006 GO:0030073 GO:0001889 GO:0016331 GO:0008285 GO:1902236 GO:0000122 GO:0045892 GO:2000675 GO:0007263 GO:0031100 GO:0010260 GO:0031016 GO:0010942 GO:0008284 GO:0043388 GO:0032024 GO:0045944 GO:0045893 GO:0006355 GO:0043279 GO:0010157 GO:0034097 GO:0042493 GO:0070542 GO:0051384 GO:0009749 GO:0010040 GO:0043201 GO:0033993 GO:0035094 GO:0031667 GO:0014070 GO:0033273 GO:0009611 GO:0007224 GO:0048863 GO:0006366 GO:0006351 GO:0060290 GO:0003309
Gene3D	1.10.10.60
InterPro	IPR017995 IPR017970 IPR001356 IPR020479 IPR009057
Pfam	PF00046
PRINTS	PR00025 PR00024
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0010468	regulation of gene expression	PMID:10802714^[1]	ECO:0000315			P	Fig 1 shows that the mice with the AdCMV-PDX-1 gene (in lanes 2-8), all show insulin production, whereas the control groups do not.	complete CACAO 5211
involved_in	GO:0010468	regulation of gene expression	PMID:10802714^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051594	detection of glucose	PMID:21108535^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21108535^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003309	type B pancreatic cell differentiation	PMID:21108535^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:19380737^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	PMID:17181874^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060290	transdifferentiation	PMID:10952464^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	PMID:15331541^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	PMID:18253862^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	PMID:19382247^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:8524276^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10094480^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18253862^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:17641871^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:10094480^[10]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3258	F	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:15650027^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:11756538^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:10094480^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	PMID:11181516^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043279	response to alkaloid	PMID:15448089^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043201	response to leucine	PMID:19438972^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:11158595^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:17991720^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:18687784^[19]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:16948396^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033993	response to lipid	PMID:17991758^[21]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033273	response to vitamin	PMID:11833042^[22]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	PMID:18439098^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	PMID:17882398^[24]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031100	animal organ regeneration	PMID:17690043^[25]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	PMID:18778483^[26]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:11309388^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:19438972^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	PMID:10580420^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010260	animal organ senescence	PMID:17467845^[29]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010157	response to chlorate	PMID:17221210^[30]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010040	response to iron(II) ion	PMID:16081762^[31]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	PMID:15148392^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	PMID:18230696^[33]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:17583748^[34]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:11158595^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19264802^[35]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1557009	F	Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:10751390^[36]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	PMID:11181516^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:15151993^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	PMID:15151993^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16887799^[38]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:15609091^[39]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10094480^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15151993^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:10094480^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[40]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000166 FB:FBgn0004053 MGI:MGI:102851 MGI:MGI:96174 PANTHER:PTN002518688 RGD:62387 UniProtKB:P14651 UniProtKB:P14652 UniProtKB:P31249	P	Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	PMID:21873635^[40]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102851 PANTHER:PTN002903050 ZFIN:ZDB-GENE-990415-122	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[40]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0051481 MGI:MGI:102851 MGI:MGI:96174 PANTHER:PTN002518688 RGD:62387 UniProtKB:O43364 UniProtKB:P14652	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[40]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000166 MGI:MGI:102851 MGI:MGI:96175 PANTHER:PTN002518688 RGD:62387	F	Seeded From UniProt	complete
involved_in	GO:0003309	type B pancreatic cell differentiation	PMID:21873635^[40]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002903050 RGD:62387 UniProtKB:P52945	P	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[40]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102851 MGI:MGI:96174 MGI:MGI:96184 PANTHER:PTN002518688 UniProtKB:P14651	F	Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52945 ensembl:ENSP00000370421	P	Seeded From UniProt	complete
involved_in	GO:0007263	nitric oxide mediated signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52945 ensembl:ENSP00000370421	P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52945 ensembl:ENSP00000370421	C	Seeded From UniProt	complete
involved_in	GO:0003309	type B pancreatic cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52945 ensembl:ENSP00000370421	P	Seeded From UniProt	complete
involved_in	GO:2000675	negative regulation of type B pancreatic cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	F	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0031017	exocrine pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	C	Seeded From UniProt	complete
involved_in	GO:0016331	morphogenesis of embryonic epithelium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	F	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	F	Seeded From UniProt	complete
involved_in	GO:0001889	liver development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52946 ensembl:ENSMUSP00000082729	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057 InterPro:IPR017995 InterPro:IPR020479	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017995	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017995	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970 InterPro:IPR017995	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:11687580^[41]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11978636^[42]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ferber, S et al. (2000) Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat. Med. 6 568-72 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gefen-Halevi, S et al. (2010) NKX6.1 promotes PDX-1-induced liver to pancreatic β-cells reprogramming. Cell Reprogram 12 655-64 PubMed GONUTS page
↑ Zhang, SS et al. (2009) Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proc. Natl. Acad. Sci. U.S.A. 106 7531-6 PubMed GONUTS page
↑ Arantes, VC et al. (2006) Palmitic acid increase levels of pancreatic duodenal homeobox-1 and p38/stress-activated protein kinase in islets from rats maintained on a low protein diet. Br. J. Nutr. 96 1006-12 PubMed GONUTS page
↑ Rooman, I et al. (2000) Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia 43 907-14 PubMed GONUTS page
↑ Gesina, E et al. (2004) Dissecting the role of glucocorticoids on pancreas development. Diabetes 53 2322-9 PubMed GONUTS page
↑ ^7.0 ^7.1 Li, H et al. (2008) Adeno-associated virus-mediated pancreatic and duodenal homeobox gene-1 expression enhanced differentiation of hepatic oval stem cells to insulin-producing cells in diabetic rats. J. Biomed. Sci. 15 487-97 PubMed GONUTS page
↑ Zhang, YH et al. (2009) Insulin-producing cells derived from rat bone marrow and their autologous transplantation in the duodenal wall for treating diabetes. Anat Rec (Hoboken) 292 728-35 PubMed GONUTS page
↑ Peers, B et al. (1995) The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain. Mol. Cell. Biol. 15 7091-7 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Andersen, FG et al. (1999) Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer. FEBS Lett. 445 315-20 PubMed GONUTS page
↑ Laybutt, DR et al. (2007) Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats. Diabetologia 50 2117-25 PubMed GONUTS page
↑ Pino, MF et al. (2005) Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element. Mol. Endocrinol. 19 1343-60 PubMed GONUTS page
↑ Qiu, Y et al. (2002) Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol. Cell. Biol. 22 412-20 PubMed GONUTS page
↑ ^14.0 ^14.1 Thomas, MK et al. (2001) Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells. Endocrinology 142 1033-40 PubMed GONUTS page
↑ Ogata, T et al. (2004) Promotion of beta-cell differentiation by conophylline in fetal and neonatal rat pancreas. Diabetes 53 2596-602 PubMed GONUTS page
↑ ^16.0 ^16.1 Zhang, X et al. (2009) AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells. J. Cell. Mol. Med. 13 758-70 PubMed GONUTS page
↑ ^17.0 ^17.1 Dutta, S et al. (2001) PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Proc. Natl. Acad. Sci. U.S.A. 98 1065-70 PubMed GONUTS page
↑ Sun, Y et al. (2008) Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate. Endocrinology 149 662-71 PubMed GONUTS page
↑ Somm, E et al. (2008) Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in life. Endocrinology 149 6289-99 PubMed GONUTS page
↑ Chin-Chance, CV et al. (2006) Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression. J. Investig. Med. 54 132-42 PubMed GONUTS page
↑ Hagman, DK et al. (2008) Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Diabetes 57 424-31 PubMed GONUTS page
↑ Yoshikawa, H et al. (2002) Effects of biotin on glucotoxicity or lipotoxicity in rat pancreatic islets. Metab. Clin. Exp. 51 163-8 PubMed GONUTS page
↑ Li, L et al. (2008) Coexpression of Pdx1 and betacellulin in mesenchymal stem cells could promote the differentiation of nestin-positive epithelium-like progenitors and pancreatic islet-like spheroids. Stem Cells Dev. 17 815-23 PubMed GONUTS page
↑ Dumortier, O et al. (2007) Different mechanisms operating during different critical time-windows reduce rat fetal beta cell mass due to a maternal low-protein or low-energy diet. Diabetologia 50 2495-503 PubMed GONUTS page
↑ Liu, T et al. (2007) PDX-1 expression and proliferation of duct epithelial cells after partial pancreatectomy in rats. HBPD INT 6 424-9 PubMed GONUTS page
↑ Hoffman, BG et al. (2008) Expression of Groucho/TLE proteins during pancreas development. BMC Dev. Biol. 8 81 PubMed GONUTS page
↑ Wang, H et al. (2001) Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation. J. Biol. Chem. 276 25279-86 PubMed GONUTS page
↑ Nielsen, K et al. (1999) Beta-cell maturation leads to in vitro sensitivity to cytotoxins. Diabetes 48 2324-32 PubMed GONUTS page
↑ Ihm, SH et al. (2007) Effect of aging on insulin secretory function and expression of beta cell function-related genes of islets. Diabetes Res. Clin. Pract. 77 Suppl 1 S150-4 PubMed GONUTS page
↑ Zertal-Zidani, S et al. (2007) Regulation of pancreatic endocrine cell differentiation by sulphated proteoglycans. Diabetologia 50 585-95 PubMed GONUTS page
↑ West, AR & Oates, PS (2005) Decreased sucrase and lactase activity in iron deficiency is accompanied by reduced gene expression and upregulation of the transcriptional repressor PDX-1. Am. J. Physiol. Gastrointest. Liver Physiol. 289 G1108-14 PubMed GONUTS page
↑ da Silva Xavier, G et al. (2004) Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. Proc. Natl. Acad. Sci. U.S.A. 101 8319-24 PubMed GONUTS page
↑ Jetton, TL et al. (2008) Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion. Am. J. Physiol. Endocrinol. Metab. 294 E679-87 PubMed GONUTS page
↑ Feanny, MA et al. (2008) PDX-1 expression is associated with islet proliferation in vitro and in vivo. J. Surg. Res. 144 8-16 PubMed GONUTS page
↑ Yang, Y et al. (2009) The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic Acids Res. 37 2529-38 PubMed GONUTS page
↑ Schwartz, PT et al. (2000) Pancreatic homeodomain transcription factor IDX1/IPF1 expressed in developing brain regulates somatostatin gene transcription in embryonic neural cells. J. Biol. Chem. 275 19106-14 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 Gauthier, BR et al. (2004) Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets. J. Biol. Chem. 279 31121-30 PubMed GONUTS page
↑ Ubeda, M et al. (2006) Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity. J. Biol. Chem. 281 28858-64 PubMed GONUTS page
↑ Taguchi, M & Otsuki, M (2004) Co-localization of nestin and PDX-1 in small evaginations of the main pancreatic duct in adult rats. J. Mol. Histol. 35 785-9 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 ^40.3 ^40.4 ^40.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Cardozo, AK et al. (2001) A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. J. Biol. Chem. 276 48879-86 PubMed GONUTS page
↑ Kojima, H et al. (2002) Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Diabetes 51 1398-408 PubMed GONUTS page

[PMID:10802714-1] 1.0 ^1.1 Ferber, S et al. (2000) Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat. Med. 6 568-72 PubMed GONUTS page

[PMID:21108535-2] 2.0 ^2.1 ^2.2 Gefen-Halevi, S et al. (2010) NKX6.1 promotes PDX-1-induced liver to pancreatic β-cells reprogramming. Cell Reprogram 12 655-64 PubMed GONUTS page

[PMID:19380737-3] Zhang, SS et al. (2009) Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proc. Natl. Acad. Sci. U.S.A. 106 7531-6 PubMed GONUTS page

[PMID:17181874-4] Arantes, VC et al. (2006) Palmitic acid increase levels of pancreatic duodenal homeobox-1 and p38/stress-activated protein kinase in islets from rats maintained on a low protein diet. Br. J. Nutr. 96 1006-12 PubMed GONUTS page

[PMID:10952464-5] Rooman, I et al. (2000) Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia 43 907-14 PubMed GONUTS page

[PMID:15331541-6] Gesina, E et al. (2004) Dissecting the role of glucocorticoids on pancreas development. Diabetes 53 2322-9 PubMed GONUTS page

[PMID:18253862-7] 7.0 ^7.1 Li, H et al. (2008) Adeno-associated virus-mediated pancreatic and duodenal homeobox gene-1 expression enhanced differentiation of hepatic oval stem cells to insulin-producing cells in diabetic rats. J. Biomed. Sci. 15 487-97 PubMed GONUTS page

[PMID:19382247-8] Zhang, YH et al. (2009) Insulin-producing cells derived from rat bone marrow and their autologous transplantation in the duodenal wall for treating diabetes. Anat Rec (Hoboken) 292 728-35 PubMed GONUTS page

[PMID:8524276-9] Peers, B et al. (1995) The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain. Mol. Cell. Biol. 15 7091-7 PubMed GONUTS page

[PMID:10094480-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Andersen, FG et al. (1999) Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer. FEBS Lett. 445 315-20 PubMed GONUTS page

[PMID:17641871-11] Laybutt, DR et al. (2007) Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats. Diabetologia 50 2117-25 PubMed GONUTS page

[PMID:15650027-12] Pino, MF et al. (2005) Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element. Mol. Endocrinol. 19 1343-60 PubMed GONUTS page

[PMID:11756538-13] Qiu, Y et al. (2002) Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol. Cell. Biol. 22 412-20 PubMed GONUTS page

[PMID:11181516-14] 14.0 ^14.1 Thomas, MK et al. (2001) Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells. Endocrinology 142 1033-40 PubMed GONUTS page

[PMID:15448089-15] Ogata, T et al. (2004) Promotion of beta-cell differentiation by conophylline in fetal and neonatal rat pancreas. Diabetes 53 2596-602 PubMed GONUTS page

[PMID:19438972-16] 16.0 ^16.1 Zhang, X et al. (2009) AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells. J. Cell. Mol. Med. 13 758-70 PubMed GONUTS page

[PMID:11158595-17] 17.0 ^17.1 Dutta, S et al. (2001) PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Proc. Natl. Acad. Sci. U.S.A. 98 1065-70 PubMed GONUTS page

[PMID:17991720-18] Sun, Y et al. (2008) Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate. Endocrinology 149 662-71 PubMed GONUTS page

[PMID:18687784-19] Somm, E et al. (2008) Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in life. Endocrinology 149 6289-99 PubMed GONUTS page

[PMID:16948396-20] Chin-Chance, CV et al. (2006) Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression. J. Investig. Med. 54 132-42 PubMed GONUTS page

[PMID:17991758-21] Hagman, DK et al. (2008) Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Diabetes 57 424-31 PubMed GONUTS page

[PMID:11833042-22] Yoshikawa, H et al. (2002) Effects of biotin on glucotoxicity or lipotoxicity in rat pancreatic islets. Metab. Clin. Exp. 51 163-8 PubMed GONUTS page

[PMID:18439098-23] Li, L et al. (2008) Coexpression of Pdx1 and betacellulin in mesenchymal stem cells could promote the differentiation of nestin-positive epithelium-like progenitors and pancreatic islet-like spheroids. Stem Cells Dev. 17 815-23 PubMed GONUTS page

[PMID:17882398-24] Dumortier, O et al. (2007) Different mechanisms operating during different critical time-windows reduce rat fetal beta cell mass due to a maternal low-protein or low-energy diet. Diabetologia 50 2495-503 PubMed GONUTS page

[PMID:17690043-25] Liu, T et al. (2007) PDX-1 expression and proliferation of duct epithelial cells after partial pancreatectomy in rats. HBPD INT 6 424-9 PubMed GONUTS page

[PMID:18778483-26] Hoffman, BG et al. (2008) Expression of Groucho/TLE proteins during pancreas development. BMC Dev. Biol. 8 81 PubMed GONUTS page

[PMID:11309388-27] Wang, H et al. (2001) Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation. J. Biol. Chem. 276 25279-86 PubMed GONUTS page

[PMID:10580420-28] Nielsen, K et al. (1999) Beta-cell maturation leads to in vitro sensitivity to cytotoxins. Diabetes 48 2324-32 PubMed GONUTS page

[PMID:17467845-29] Ihm, SH et al. (2007) Effect of aging on insulin secretory function and expression of beta cell function-related genes of islets. Diabetes Res. Clin. Pract. 77 Suppl 1 S150-4 PubMed GONUTS page

[PMID:17221210-30] Zertal-Zidani, S et al. (2007) Regulation of pancreatic endocrine cell differentiation by sulphated proteoglycans. Diabetologia 50 585-95 PubMed GONUTS page

[PMID:16081762-31] West, AR & Oates, PS (2005) Decreased sucrase and lactase activity in iron deficiency is accompanied by reduced gene expression and upregulation of the transcriptional repressor PDX-1. Am. J. Physiol. Gastrointest. Liver Physiol. 289 G1108-14 PubMed GONUTS page

[PMID:15148392-32] Silva Xavier, G et al. (2004) Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. Proc. Natl. Acad. Sci. U.S.A. 101 8319-24 PubMed GONUTS page

[PMID:18230696-33] Jetton, TL et al. (2008) Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion. Am. J. Physiol. Endocrinol. Metab. 294 E679-87 PubMed GONUTS page

[PMID:17583748-34] Feanny, MA et al. (2008) PDX-1 expression is associated with islet proliferation in vitro and in vivo. J. Surg. Res. 144 8-16 PubMed GONUTS page

[PMID:19264802-35] Yang, Y et al. (2009) The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic Acids Res. 37 2529-38 PubMed GONUTS page

[PMID:10751390-36] Schwartz, PT et al. (2000) Pancreatic homeodomain transcription factor IDX1/IPF1 expressed in developing brain regulates somatostatin gene transcription in embryonic neural cells. J. Biol. Chem. 275 19106-14 PubMed GONUTS page

[PMID:15151993-37] 37.0 ^37.1 ^37.2 Gauthier, BR et al. (2004) Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets. J. Biol. Chem. 279 31121-30 PubMed GONUTS page

[PMID:16887799-38] Ubeda, M et al. (2006) Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity. J. Biol. Chem. 281 28858-64 PubMed GONUTS page

[PMID:15609091-39] Taguchi, M & Otsuki, M (2004) Co-localization of nestin and PDX-1 in small evaginations of the main pancreatic duct in adult rats. J. Mol. Histol. 35 785-9 PubMed GONUTS page

[PMID:21873635-40] 40.0 ^40.1 ^40.2 ^40.3 ^40.4 ^40.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11687580-41] Cardozo, AK et al. (2001) A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. J. Biol. Chem. 276 48879-86 PubMed GONUTS page

[PMID:11978636-42] Kojima, H et al. (2002) Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Diabetes 51 1398-408 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

RAT:PDX1

Contents

Annotations

Notes

References

a

c

d

e

g

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools