PMID:17583748

Citation	Feanny, MA, Fagan, SP, Ballian, N, Liu, SH, Li, Z, Wang, X, Fisher, W, Brunicardi, FC and Belaguli, NS (2008) PDX-1 expression is associated with islet proliferation in vitro and in vivo. J. Surg. Res. 144:8-16
Abstract	Transcription factor pancreatic duodenal homeobox-1 (PDX-1) is critical for beta-cell differentiation and insulin gene expression. In this study, we investigated the role of PDX-1 in ductal-to-islet cell transdifferentiation, islet cell apoptosis, and proliferation in addition to other regulators associated with these processes in two developing beta-cell models.
Links	PubMed Online version:10.1016/j.jss.2007.04.018
Keywords	Animals; Apoptosis/drug effects; Apoptosis/physiology; Cell Differentiation/drug effects; Cell Differentiation/physiology; Cell Division/drug effects; Cell Division/physiology; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27/genetics; Cyclin-Dependent Kinase Inhibitor p27/metabolism; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Humans; Hypoglycemic Agents/pharmacology; Insulin; Islets of Langerhans/cytology; Islets of Langerhans/drug effects; Islets of Langerhans/physiology; Male; Models, Animal; Pancreatectomy; Peptides/pharmacology; Proinsulin/genetics; Proinsulin/metabolism; Protein Precursors/genetics; Protein Precursors/metabolism; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin/genetics; Receptors, Somatostatin/metabolism; Regeneration/drug effects; Regeneration/physiology; Trans-Activators/genetics; Trans-Activators/metabolism; Venoms/pharmacology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RAT:PDX1	involved_in	GO:0009611: response to wounding	ECO:0000270: expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete

References

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