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PMID:17641871

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Citation

Laybutt, DR, Hawkins, YC, Lock, J, Lebet, J, Sharma, A, Bonner-Weir, S and Weir, GC (2007) Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats. Diabetologia 50:2117-25

Abstract

Hyperglycaemia can impair beta cell function after islet transplantation. Appropriate glucose-induced insulin secretion is dependent on a unique expression pattern of genes. Here we examined the effects of diabetes on gene expression in transplanted islets.

Links

PubMed Online version:10.1007/s00125-007-0749-2

Keywords

Animals; Blood Glucose/metabolism; Diabetes Mellitus, Experimental/genetics; Diabetes Mellitus, Experimental/pathology; Diabetes Mellitus, Experimental/surgery; Disease Models, Animal; Gene Expression Regulation; Insulin/blood; Insulin-Secreting Cells/pathology; Islets of Langerhans Transplantation; Male; Potassium Channels, Inwardly Rectifying/genetics; RNA, Messenger/genetics; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transplantation, Homologous

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:PDX1

involved_in

GO:0045892: negative regulation of transcription, DNA-templated

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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