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PMID:17991758

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Citation

Hagman, DK, Latour, MG, Chakrabarti, SK, Fontes, G, Amyot, J, Tremblay, C, Semache, M, Lausier, JA, Roskens, V, Mirmira, RG, Jetton, TL and Poitout, V (2008) Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets. Diabetes 57:424-31

Abstract

Prolonged exposure of isolated islets of Langerhans to elevated levels of fatty acids, in the presence of high glucose, impairs insulin gene expression via a transcriptional mechanism involving nuclear exclusion of pancreas-duodenum homeobox-1 (Pdx-1) and loss of MafA expression. Whether such a phenomenon also occurs in vivo is unknown. Our objective was therefore to ascertain whether chronic nutrient oversupply inhibits insulin gene expression in vivo.

Links

PubMed PMC2979006 Online version:10.2337/db07-1285

Keywords

Animals; Blood Glucose/metabolism; C-Peptide/drug effects; C-Peptide/secretion; Fat Emulsions, Intravenous/administration & dosage; Fat Emulsions, Intravenous/pharmacology; Fatty Acids, Nonesterified/blood; Gene Expression Regulation/drug effects; Glucose/administration & dosage; Glucose/pharmacology; Glucose Tolerance Test; Homeodomain Proteins/drug effects; Homeodomain Proteins/metabolism; Hyperglycemia; Infusions, Intravenous; Insulin/genetics; Insulin/secretion; Islets of Langerhans/drug effects; Islets of Langerhans/secretion; Male; RNA, Messenger/genetics; Rats; Rats, Wistar; Trans-Activators/drug effects; Trans-Activators/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:PDX1

involved_in

GO:0033993: response to lipid

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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