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PMID:17882398

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Citation

Dumortier, O, Blondeau, B, Duvillié, B, Reusens, B, Bréant, B and Remacle, C (2007) Different mechanisms operating during different critical time-windows reduce rat fetal beta cell mass due to a maternal low-protein or low-energy diet. Diabetologia 50:2495-503

Abstract

Adverse events during intra-uterine life may programme organ growth and favour disease later in life. In animals, protein or energy restriction during gestation alters the development of the endocrine pancreas, even though the duration of malnutrition is different. Here, we evaluate the specific effects of both diets during different periods of gestation and the mechanisms underlying the decreased beta cell mass.

Links

PubMed Online version:10.1007/s00125-007-0811-0

Keywords

Animals; Blood Glucose/analysis; Caloric Restriction; Corticosterone/analysis; Diet, Protein-Restricted/adverse effects; Diet, Reducing/adverse effects; Energy Intake/physiology; Female; Fetal Weight; Gestational Age; Insulin/analysis; Insulin-Secreting Cells/cytology; Islets of Langerhans/anatomy & histology; Islets of Langerhans/blood supply; Islets of Langerhans/chemistry; Islets of Langerhans/embryology; Maternal-Fetal Exchange/physiology; Organ Size; Pancreas, Exocrine/anatomy & histology; Pancreas, Exocrine/embryology; Pregnancy; Protein-Energy Malnutrition/embryology; Rats; Rats, Wistar; Signal Transduction/physiology; Time Factors

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:PDX1

involved_in

GO:0031667: response to nutrient levels

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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