GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search

Ogata, T, Li, L, Yamada, S, Yamamoto, Y, Tanaka, Y, Takei, I, Umezawa, K and Kojima, I (2004) Promotion of beta-cell differentiation by conophylline in fetal and neonatal rat pancreas. Diabetes 53:2596-602


Conophylline is a vinca alkaloid extracted from the tropical plant Ervatamia microphylla and has been shown to induce differentiation of pancreatic AR42J cells. In the present study, we investigated the effect of conophylline on the differentiation of pancreatic precursor cells. In the rat pancreatic rudiment in organ culture, conophylline inhibited the formation of cystic structure and increased the number of insulin-positive cells. Conophylline also markedly increased the expression of mRNA for insulin and the number of pancreatic duodenal homeobox-1-positive cells. These effects of conophylline were similar to those of activin A. We also examined the effect of conophylline on neonatal rats treated with streptozotocin, a model of type 2 diabetes. Treatment with conophylline significantly reduced the plasma glucose concentration and improved glucose tolerance in response to glucose loading. The insulin content and the beta-cell mass at 2 months were significantly increased by conophylline. The number of islet-like cell clusters and pancreatic duodenal homeobox-1-positive ductal cells was greater in conophylline-treated rats. These results suggest that conophylline induces differentiation of pancreatic precursor cells and increases the formation of beta-cells.




Activins/pharmacology; Animals; Animals, Newborn; Cell Culture Techniques; Cell Differentiation/drug effects; Female; Inhibin-beta Subunits/pharmacology; Islets of Langerhans/cytology; Islets of Langerhans/drug effects; Islets of Langerhans/embryology; Islets of Langerhans/growth & development; Pancreas/cytology; Pancreas/drug effects; Pancreas/embryology; Pancreas/growth & development; Pregnancy; Rats; Rats, Wistar; Vinca Alkaloids/pharmacology



Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status



GO:0043279: response to alkaloid

ECO:0000270: expression pattern evidence used in manual assertion


Seeded From UniProt


See also


See Help:References for how to manage references in GONUTS.