GONUTS has been updated to MW1.29.2. Most things seem to be working but be sure to report problems.

It is now the 6th OPEN Period for CACAO Spring 2018! It will end on Monday April 23, 2018 at 05:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

It is now the 4th OPEN Period for CACAO Phage Hunters 2018! It will end on Sunday April 22, 2018 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

DROME:Q8IMZ4

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided.
Protein Name(s) P53 protein long form variant 1 (ECO:0000313 with EMBL:ABB80263.1)

p53, isoform B (ECO:0000313 with EMBL:AAN13925.2)

External Links
UniProt Q8IMZ4
EMBL AE014297
DQ191318
RefSeq NP_996267.1
UniGene Dm.3257
SMR Q8IMZ4
IntAct Q8IMZ4
MINT MINT-4053220
EnsemblMetazoa FBtr0084360
GeneID 2768677
KEGG dme:Dmel_CG33336
UCSC CG33336-RB
CTD 2768677
FlyBase FBgn0039044
KO K10149
OMA KICTCPK
PhylomeDB Q8IMZ4
GenomeRNAi 2768677
NextBio 848043
Proteomes UP000000803
GO GO:0000785
GO:0005829
GO:0005634
GO:0005667
GO:0003682
GO:0001047
GO:0003684
GO:0003690
GO:0002039
GO:0001085
GO:0043565
GO:0003700
GO:0008134
GO:0031624
GO:0031625
GO:0006919
GO:0006915
GO:0008219
GO:0006974
GO:0071480
GO:0009267
GO:0034644
GO:0008340
GO:0030330
GO:0006978
GO:0035234
GO:0072332
GO:0008630
GO:0042771
GO:0031571
GO:0046533
GO:0000122
GO:0014016
GO:0007405
GO:0048477
GO:0045787
GO:2000685
GO:0016239
GO:0045944
GO:0045893
GO:0007131
GO:0042127
GO:0006282
GO:0043523
GO:0046620
GO:0006357
GO:1990248
GO:0010332
GO:0010212
GO:0009314
GO:0009411
GO:0010165
GO:0042246
Gene3D 2.60.40.720
InterPro IPR008967
IPR012346
IPR024631
IPR011615
IPR002117
PANTHER PTHR11447
Pfam PF00870
PF11619
SUPFAM SSF49417

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:25453105[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001047

core promoter binding

PMID:24265704[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001085

RNA polymerase II transcription factor binding

PMID:18549481[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9V4D4

F

Seeded From UniProt

complete

GO:0001097

TFIIH-class transcription factor binding

PMID:23549790[4]

IPI: Inferred from Physical Interaction

FB:FBgn0261109

F

Seeded From UniProt

complete

GO:0002039

p53 binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002117
InterPro:IPR012346

F

Seeded From UniProt

complete

GO:0003682

chromatin binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

F

Seeded From UniProt

complete

GO:0003684

damaged DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

F

Seeded From UniProt

complete

GO:0003690

double-stranded DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002117
InterPro:IPR008967
InterPro:IPR012346

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17933869[5]

IPI: Inferred from Physical Interaction

FB:FBgn0031820

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002117
InterPro:IPR012346

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:19153663[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005667

transcription factor complex

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

C

Seeded From UniProt

complete

GO:0005829

cytosol

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

C

Seeded From UniProt

complete

GO:0006282

regulation of DNA repair

PMID:14729967[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002117
InterPro:IPR008967
InterPro:IPR012346

P

Seeded From UniProt

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

PMID:11139272[8]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

PMID:25211335[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002117

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10910336[10]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:12072176[11]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:16079158[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:17310982[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006974

cellular response to DNA damage stimulus

PMID:14532134[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006974

cellular response to DNA damage stimulus

PMID:19543366[15]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0007131

reciprocal meiotic recombination

PMID:20522776[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007405

neuroblast proliferation

PMID:22140513[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008134

transcription factor binding

PMID:18549481[3]

IPI: Inferred from Physical Interaction

FB:FBgn0026262

F

Seeded From UniProt

complete

GO:0008219

cell death

PMID:12672954[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:16303568[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:12006672[20]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:18688282[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009267

cellular response to starvation

PMID:18794330[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009314

response to radiation

PMID:11139272[8]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0009314

response to radiation

PMID:12672954[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009411

response to UV

PMID:16412438[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010165

response to X-ray

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0010212

response to ionizing radiation

PMID:17933869[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010212

response to ionizing radiation

PMID:24240233[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0014016

neuroblast differentiation

PMID:22140513[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016239

positive regulation of macroautophagy

PMID:18794330[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030330

DNA damage response, signal transduction by p53 class mediator

PMID:12006672[20]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030330

DNA damage response, signal transduction by p53 class mediator

PMID:12072176[11]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0031571

mitotic G1 DNA damage checkpoint

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0031624

ubiquitin conjugating enzyme binding

PMID:21205821[25]

IPI: Inferred from Physical Interaction

FB:FBgn0004436

F

Seeded From UniProt

complete

GO:0031624

ubiquitin conjugating enzyme binding

PMID:21205821[25]

IPI: Inferred from Physical Interaction

UniProtKB:P25153

F

Seeded From UniProt

complete

GO:0031625

ubiquitin protein ligase binding

PMID:17170702[26]

IPI: Inferred from Physical Interaction

FB:FBgn0039875

F

Seeded From UniProt

complete

GO:0034644

cellular response to UV

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0035234

ectopic germ cell programmed cell death

PMID:20838898[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042127

regulation of cell proliferation

PMID:21179433[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042246

tissue regeneration

PMID:16920621[29]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042594

response to starvation

PMID:25017064[30]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:10778860[31]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:11063934[32]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:12172011[33]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:12935877[34]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:16860746[35]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:21205821[25]

IGI: Inferred from Genetic Interaction

UniProtKB:P25153

P

Seeded From UniProt

complete

GO:0043523

regulation of neuron apoptotic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

F

Seeded From UniProt

complete

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011615

F

Seeded From UniProt

complete

GO:0045787

positive regulation of cell cycle

PMID:16326395[36]

IGI: Inferred from Genetic Interaction

FB:FBgn0019624

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:10778860[31]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:17933869[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:24265704[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:12172011[33]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046533

negative regulation of photoreceptor cell differentiation

PMID:19960025[37]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046620

regulation of organ growth

PMID:21179433[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:20522776[16]

IGI: Inferred from Genetic Interaction

FB:FBgn0002989

P

Seeded From UniProt

complete

GO:0071480

cellular response to gamma radiation

PMID:12172011[33]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071480

cellular response to gamma radiation

PMID:24265704[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

PMID:12172011[33]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1990248

regulation of transcription from RNA polymerase II promoter in response to DNA damage

PMID:24265704[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000685

positive regulation of cellular response to X-ray

PMID:14729967[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

colocalizes_with

GO:0035327

transcriptionally active chromatin

PMID:19153663[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Merlo, P et al. (2014) p53 prevents neurodegeneration by regulating synaptic genes. Proc. Natl. Acad. Sci. U.S.A. 111 18055-60 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Zhang, C et al. (2013) Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage. PLoS ONE 8 e78652 PubMed GONUTS page
  3. 3.0 3.1 Bereczki, O et al. (2008) TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. BMC Mol. Biol. 9 57 PubMed GONUTS page
  4. Villicaña, C et al. (2013) The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila. J. Cell. Sci. 126 2502-15 PubMed GONUTS page
  5. 5.0 5.1 5.2 Bodai, L et al. (2007) Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level. J. Biol. Chem. 282 36386-93 PubMed GONUTS page
  6. 6.0 6.1 Schauer, T et al. (2009) Misregulated RNA Pol II C-terminal domain phosphorylation results in apoptosis. Cell. Mol. Life Sci. 66 909-18 PubMed GONUTS page
  7. 7.0 7.1 Brodsky, MH et al. (2004) Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol. Cell. Biol. 24 1219-31 PubMed GONUTS page
  8. 8.0 8.1 Kumar, S (2000) Cell death in the fly comes of age. Cell Death Differ. 7 1021-4 PubMed GONUTS page
  9. Zhang, B et al. (2014) Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells. PLoS Genet. 10 e1004581 PubMed GONUTS page
  10. De Laurenzi, V & Melino, G (2000) Apoptosis. The little devil of death. Nature 406 135-6 PubMed GONUTS page
  11. 11.0 11.1 Richardson, H & Kumar, S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods 265 21-38 PubMed GONUTS page
  12. McEwen, DG & Peifer, M (2005) Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis. Development 132 3935-46 PubMed GONUTS page
  13. Akdemir, F et al. (2007) p53 directs focused genomic responses in Drosophila. Oncogene 26 5184-93 PubMed GONUTS page
  14. Jassim, OW et al. (2003) Dmp53 protects the Drosophila retina during a developmentally regulated DNA damage response. EMBO J. 22 5622-32 PubMed GONUTS page
  15. Ravi, D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet. 5 e1000527 PubMed GONUTS page
  16. 16.0 16.1 Lu, WJ et al. (2010) Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328 1278-81 PubMed GONUTS page
  17. 17.0 17.1 Ouyang, Y et al. (2011) dp53 Restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and cyclin E. PLoS ONE 6 e28098 PubMed GONUTS page
  18. 18.0 18.1 Sogame, N et al. (2003) Drosophila p53 preserves genomic stability by regulating cell death. Proc. Natl. Acad. Sci. U.S.A. 100 4696-701 PubMed GONUTS page
  19. Bauer, JH et al. (2005) Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15 2063-8 PubMed GONUTS page
  20. 20.0 20.1 Gorski, S & Marra, M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol. Genomics 9 59-69 PubMed GONUTS page
  21. Moon, NS et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet. 4 e1000153 PubMed GONUTS page
  22. 22.0 22.1 Hou, YC et al. (2008) Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis. J. Cell Biol. 182 1127-39 PubMed GONUTS page
  23. Rebollar, E et al. (2006) Role of the p53 homologue from Drosophila melanogaster in the maintenance of histone H3 acetylation and response to UV-light irradiation. FEBS Lett. 580 642-8 PubMed GONUTS page
  24. Link, N et al. (2013) A p53 enhancer region regulates target genes through chromatin conformations in cis and in trans. Genes Dev. 27 2433-8 PubMed GONUTS page
  25. 25.0 25.1 25.2 Chen, S et al. (2011) E2 ligase dRad6 regulates DMP53 turnover in Drosophila. J. Biol. Chem. 286 9020-30 PubMed GONUTS page
  26. Yamasaki, S et al. (2007) Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J. 26 113-22 PubMed GONUTS page
  27. Bakhrat, A et al. (2010) Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis. Apoptosis 15 1425-34 PubMed GONUTS page
  28. 28.0 28.1 Mesquita, D et al. (2010) A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila. PLoS Biol. 8 e1000566 PubMed GONUTS page
  29. Wells, BS et al. (2006) Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr. Biol. 16 1606-15 PubMed GONUTS page
  30. Barrio, L et al. (2014) MicroRNA-mediated regulation of Dp53 in the Drosophila fat body contributes to metabolic adaptation to nutrient deprivation. Cell Rep 8 528-41 PubMed GONUTS page
  31. 31.0 31.1 Brodsky, MH et al. (2000) Drosophila p53 binds a damage response element at the reaper locus. Cell 101 103-13 PubMed GONUTS page
  32. Walworth, NC (2000) Cell-cycle checkpoint kinases: checking in on the cell cycle. Curr. Opin. Cell Biol. 12 697-704 PubMed GONUTS page
  33. 33.0 33.1 33.2 33.3 Peters, M et al. (2002) Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 99 11305-10 PubMed GONUTS page
  34. Lee, JH et al. (2003) In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. FEBS Lett. 550 5-10 PubMed GONUTS page
  35. Colombani, J et al. (2006) Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage. Curr. Biol. 16 1453-8 PubMed GONUTS page
  36. Mandal, S et al. (2005) Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev. Cell 9 843-54 PubMed GONUTS page
  37. Fan, Y et al. (2010) Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Differ. 17 912-21 PubMed GONUTS page