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Wells, BS, Yoshida, E and Johnston, LA (2006) Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr. Biol. 16:1606-15
The p53 transcription factor directs a transcriptional program that determines whether a cell lives or dies after DNA damage. Animal survival after extensive cellular damage often requires that lost tissue be replaced through compensatory growth or regeneration. In Drosophila, damaged imaginal disc cells can induce the proliferation of neighboring viable cells, but how this is controlled is not clear. Here we provide evidence that Drosophila p53 (dp53) has a previously unidentified role in coordinating the compensatory growth response to tissue damage.
Animals; Caspases/metabolism; Caspases/physiology; Cell Proliferation; Drosophila/growth & development; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Extremities/physiology; Flow Cytometry; Immunohistochemistry; Larva/growth & development; Larva/physiology; Morphogenesis/physiology; Regeneration/physiology; Tumor Suppressor Protein p53/metabolism; Tumor Suppressor Protein p53/physiology
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