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PMID:16920621

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Citation

Wells, BS, Yoshida, E and Johnston, LA (2006) Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr. Biol. 16:1606-15

Abstract

The p53 transcription factor directs a transcriptional program that determines whether a cell lives or dies after DNA damage. Animal survival after extensive cellular damage often requires that lost tissue be replaced through compensatory growth or regeneration. In Drosophila, damaged imaginal disc cells can induce the proliferation of neighboring viable cells, but how this is controlled is not clear. Here we provide evidence that Drosophila p53 (dp53) has a previously unidentified role in coordinating the compensatory growth response to tissue damage.

Links

PubMed PMC1764442 Online version:10.1016/j.cub.2006.07.046

Keywords

Animals; Caspases/metabolism; Caspases/physiology; Cell Proliferation; Drosophila/growth & development; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Extremities/physiology; Flow Cytometry; Immunohistochemistry; Larva/growth & development; Larva/physiology; Morphogenesis/physiology; Regeneration/physiology; Tumor Suppressor Protein p53/metabolism; Tumor Suppressor Protein p53/physiology

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

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