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PMID:19960025

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Citation

Fan, Y, Lee, TV, Xu, D, Chen, Z, Lamblin, AF, Steller, H and Bergmann, A (2010) Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Differ. 17:912-21

Abstract

The mammalian p53 family consists of p53, p63 and p73. Whereas p53 accounts for tumor suppression through cell-cycle arrest and apoptosis, the functions of p63 and p73 are more diverse and also include control of cell differentiation. The Drosophila genome contains only one p53 homolog, Dp53. Previous work has established that Drosophila p53 (Dp53) induces apoptosis, but not cell-cycle arrest. In this study, using the developing eye as a model, we show that Dp53-induced apoptosis is primarily dependent on the pro-apoptotic gene, head involution defective (hid), but not reaper (rpr), and occurs through the canonical apoptosis pathway. Importantly, similar to p63 and p73, expression of Dp53 also inhibits cellular differentiation of photoreceptor neurons and cone cells in the eye independently of its apoptotic function. Intriguingly, expression of the human cell-cycle inhibitor p21 or its Drosophila homolog dacapo (dap) can suppress both Dp53-induced cell death and differentiation defects in Drosophila eyes. These findings provide new insights into the pathways activated by Dp53 and reveal that Dp53 incorporates functions of multiple p53 family members.

Links

PubMed PMC3014827 Online version:10.1038/cdd.2009.182

Keywords

Animals; Apoptosis; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Drosophila/cytology; Drosophila/metabolism; Drosophila Proteins/antagonists & inhibitors; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Eye/cytology; Eye/metabolism; Humans; Neuropeptides/metabolism; Nuclear Proteins/metabolism; Tumor Suppressor Protein p53/antagonists & inhibitors; Tumor Suppressor Protein p53/metabolism; Tumor Suppressor Protein p53/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:A0A0B4K7P1

involved_in

GO:0046533: negative regulation of photoreceptor cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2XVY6

involved_in

GO:0046533: negative regulation of photoreceptor cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2XVY7

involved_in

GO:0046533: negative regulation of photoreceptor cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IH92

involved_in

GO:0046533: negative regulation of photoreceptor cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9N6D8

involved_in

GO:0046533: negative regulation of photoreceptor cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IMZ4

involved_in

GO:0046533: negative regulation of photoreceptor cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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