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PMID:11063934

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Citation

Walworth, NC (2000) Cell-cycle checkpoint kinases: checking in on the cell cycle. Curr. Opin. Cell Biol. 12:697-704

Abstract

In response to DNA damage, cell-cycle checkpoints integrate cell-cycle control with DNA repair. The idea that checkpoint controls are an integral component of normal cell-cycle progression has arisen as a result of studies in Drosophila and mice. In addition, an appreciation that DNA damage arises as a natural consequence of cellular metabolism, including DNA replication itself, has influenced thinking regarding the nature of checkpoint pathways.

Links

PubMed

Keywords

Animals; Cell Cycle/physiology; Cell Cycle Proteins; Cell Transformation, Neoplastic/genetics; DNA Repair/physiology; DNA Replication/physiology; DNA-Binding Proteins; Drosophila; Embryo, Mammalian/enzymology; Embryo, Mammalian/pathology; Embryo, Nonmammalian/enzymology; Embryo, Nonmammalian/pathology; Genes, cdc/physiology; Genetic Predisposition to Disease; Mice; Protein Kinases/genetics; Protein Kinases/metabolism; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism; Tumor Suppressor Protein p53/metabolism; Tumor Suppressor Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:A0A0B4K7P1

involved_in

GO:0042771: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2XVY6

involved_in

GO:0042771: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2XVY7

involved_in

GO:0042771: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IH92

involved_in

GO:0042771: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:ATRIP

involved_in

GO:0007444: imaginal disc development

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:ATRIP

involved_in

GO:0009314: response to radiation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:ATR

involved_in

GO:0007444: imaginal disc development

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:ATR

involved_in

GO:0007349: cellularization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:ATR

involved_in

GO:0009314: response to radiation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:ATR

involved_in

GO:0001700: embryonic development via the syncytial blastoderm

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9N6D8

involved_in

GO:0042771: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IMZ4

involved_in

GO:0042771: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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