Category:Team CFP

Figure 5: The authors used AG1748 to block ErbB4/neuregulin interaction in zebrafish embryos, thereby phenocopying loss of neuregulin signaling (control: DMSO injection).

Perlin et al. used anti-sense MOs to knockdown neuregulin expression, and Figure 1 shows that in zebrafish morphants, there was a reduction of Schwann cells occupying the PLLn.

Expression of dominant negative ErbB4 mutant inhibited extension of leading process on rhombic lip (Figure 7)

Data from a chromatin immunoprecipitation assay, tehy identified a direct association of Zif268 with the GDNF promoter, and Figure 1 shows that Dopamine D2 receptor (D2R) activation increases glial cell line–derived neurotrophic factor (GDNF) mRNA and protein levels

Generated mutant ErbB4 receptors (truncated receptors)

performed in vitro explant assay to understand if ErbB signaling is involved in regulation of head mesoderm migration (Figure 6)

Vimentin involvement in lamellipodia formation was inferred from silencing experiments.

"Retroviral-driven misexpression of neuroD in monolayer cultures of retinal pigment epithelium yielded de novo production of photoreceptor cells with no other types of retinal neurons detected. We propose that neuroD is important for photoreceptor cell production in the vertebrate retina."

Figure 1: LULL1 promotes relocalization of TorA to the NE

They studied the subcellular localization of TorA with mGFP fused to its C-terminus in transfected U2OS cells

Expression of dominant negative ErbB4 mutant inhibited extension of leading process on rhombic lip (Figure 7)

See figure 1.

"The ability of NLGN1 to induce neurite outgrowth was

evaluated by incubating the neurons with increasing concentrations of recombinant NLGN1." (Page 4177) This was followed by fluorescence staining.

Figure S4: Analysis of insulin granule docking in pancreatic islets from NL-2 knockout mice.

Fig Supplementary 3 (or Fig 9).

Inferred from electrophysiology experiments. See figure 3.

Figure 1: Increased concentration of protein at the NMJs.