HUMAN:DRD2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DRD2
Protein Name(s)	D(2) dopamine receptor Dopamine D2 receptor
External Links
UniProt	P14416
EMBL	M30625 X51645 X51646 X51362 M29066 S62137 S69899 S58589 S58577 S58584 S58586 S58588 AF176812 AB065860 AF050737 BC021195
CCDS	CCDS8361.1 CCDS8362.1
PIR	S08417
RefSeq	NP_000786.1 NP_057658.2 XP_005271482.1 XP_006718837.1
UniGene	Hs.73893
PDB	1I15 2YOU
PDBsum	1I15 2YOU
ProteinModelPortal	P14416
SMR	P14416
BioGrid	108147
DIP	DIP-5977N
IntAct	P14416
MINT	MINT-201447
STRING	9606.ENSP00000354859
BindingDB	P14416
ChEMBL	CHEMBL2095396
DrugBank	DB01614 DB01063 DB01425 DB00915 DB06288 DB00543 DB00182 DB00714 DB01238 DB06216 DB01200 DB00490 DB00248 DB00477 DB01239 DB00568 DB00363 DB01151 DB01184 DB00988 DB01142 DB00450 DB01049 DB00696 DB00875 DB00623 DB04842 DB00502 DB04946 DB00458 DB01221 DB01235 DB00589 DB00408 DB08815 DB00934 DB01043 DB00933 DB01403 DB01233 DB06148 DB00805 DB00370 DB01618 DB00540 DB00334 DB01267 DB01186 DB00850 DB01100 DB01621 DB00413 DB00433 DB00420 DB01069 DB00777 DB01224 DB00409 DB00734 DB00268 DB05271 DB06144 DB00391 DB04844 DB01622 DB00679 DB01623 DB00831 DB00508 DB00726 DB01392 DB00246
GuidetoPHARMACOLOGY	215
PhosphoSite	P14416
DMDM	118206
PaxDb	P14416
PRIDE	P14416
DNASU	1813
Ensembl	ENST00000346454 ENST00000362072 ENST00000538967 ENST00000542968
GeneID	1813
KEGG	hsa:1813
UCSC	uc001pnz.3 uc001pob.4
CTD	1813
GeneCards	GC11M113280
HGNC	HGNC:3023
HPA	HPA015691
MIM	103780 126450 159900
neXtProt	NX_P14416
Orphanet	36899
PharmGKB	PA27478
eggNOG	NOG309657
GeneTree	ENSGT00770000120457
HOVERGEN	HBG106962
InParanoid	P14416
KO	K04145
OMA	NSVKHSR
OrthoDB	EOG769ZMG
PhylomeDB	P14416
TreeFam	TF334382
Reactome	REACT_16968 REACT_19231
SignaLink	P14416
EvolutionaryTrace	P14416
GeneWiki	Dopamine_receptor_D2
GenomeRNAi	1813
NextBio	7389
PRO	PR:P14416
Proteomes	UP000005640
Bgee	P14416
CleanEx	HS_DRD2
ExpressionAtlas	P14416
Genevestigator	P14416
GO	GO:0001669 GO:0030424 GO:0043679 GO:0030425 GO:0043197 GO:0030139 GO:0005887 GO:0016328 GO:0043204 GO:0005886 GO:0014069 GO:0036126 GO:0030672 GO:0035240 GO:0001591 GO:0008144 GO:0042802 GO:0015459 GO:0032147 GO:0021984 GO:0007195 GO:0007628 GO:0050482 GO:0008306 GO:0031223 GO:0007409 GO:0048148 GO:0048149 GO:0048755 GO:0006874 GO:0021853 GO:0032922 GO:0042417 GO:0007631 GO:0002031 GO:0007625 GO:0035556 GO:0007626 GO:0007616 GO:0007194 GO:0045776 GO:0030336 GO:0008285 GO:0042321 GO:0051481 GO:0060160 GO:0033602 GO:0046676 GO:0051898 GO:0050709 GO:0051967 GO:1901386 GO:0001976 GO:0007270 GO:0021769 GO:0030432 GO:0046488 GO:0060158 GO:0043473 GO:0032467 GO:0051482 GO:0051586 GO:0070374 GO:0045745 GO:0060124 GO:1900273 GO:0040018 GO:0002052 GO:0002092 GO:0035815 GO:0045944 GO:0035810 GO:0060134 GO:0008104 GO:0030814 GO:0051584 GO:0002027 GO:0090325 GO:0048169 GO:0043666 GO:0043266 GO:0002028 GO:0051823 GO:0032228 GO:0051209 GO:0001975 GO:0048678 GO:0042220 GO:0042493 GO:0034776 GO:0001666 GO:0014854 GO:0010039 GO:0009416 GO:0043278 GO:0035094 GO:0009636 GO:0007608 GO:0021756 GO:0007416 GO:0001963 GO:0001659 GO:0008542 GO:0016055
InterPro	IPR001922 IPR000929 IPR000276 IPR017452
Pfam	PF00001
PRINTS	PR00567 PR00242 PR00237
PROSITE	PS00237 PS50262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	PMID:26554819^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:26554819^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:21711983^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097730	non-motile cilium	PMID:20531939^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0060170	ciliary membrane	PMID:20531939^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900168	positive regulation of glial cell-derived neurotrophic factor secretion	PMID:23373701^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	PMID:22888021^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060160	negative regulation of dopamine receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0051967	negative regulation of synaptic transmission, glutamatergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0051584	regulation of dopamine uptake involved in synaptic transmission	PMID:8301582^[6]	ECO:0000305	curator inference used in manual assertion	GO:0001591	P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61169-2	P		Seeded From UniProt	complete
involved_in	GO:0050709	negative regulation of protein secretion	PMID:16839358^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050482	arachidonic acid secretion	PMID:8301582^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048755	branching morphogenesis of a nerve	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0048149	behavioral response to ethanol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0043266	regulation of potassium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61169	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61169	P		Seeded From UniProt	complete
involved_in	GO:0042417	dopamine metabolic process	PMID:8301582^[6]	ECO:0000305	curator inference used in manual assertion	GO:0001591	P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0034776	response to histamine	PMID:16839358^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0032228	regulation of synaptic transmission, GABAergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	PMID:8666994^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030432	peristalsis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	C		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0021984	adenohypophysis development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0021853	cerebral cortex GABAergic interneuron migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0009416	response to light stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0008306	associative learning	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:8413587^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0007628	adult walking behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0007608	sensory perception of smell	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61169	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0007270	neuron-neuron synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:8413587^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0002028	regulation of sodium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0002027	regulation of heart rate	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61168	P		Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	PMID:8301582^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	PMID:21711983^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0007212)	Seeded From UniProt	complete
involved_in	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001205212 UniProtKB:P08588 UniProtKB:P18871	P		Seeded From UniProt	complete
involved_in	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000664502 RGD:2520	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004514 FB:FBgn0035538 FB:FBgn0038541 FB:FBgn0038542 PANTHER:PTN000664502 UniProtKB:P07550 UniProtKB:P08913 UniProtKB:P14416 UniProtKB:P18825 UniProtKB:P18871 UniProtKB:P35462 WB:WBGene00004777	C		Seeded From UniProt	complete
enables	GO:0004935	adrenergic receptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87934 MGI:MGI:87935 PANTHER:PTN000664502	F		Seeded From UniProt	complete
involved_in	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	PMID:17194762^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21728	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:28154160^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18668123^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14416	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	C		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0021984	adenohypophysis development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0021853	cerebral cortex GABAergic interneuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0009416	response to light stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0008306	associative learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0007631	feeding behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0007628	adult walking behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0007625	grooming behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0007608	sensory perception of smell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0007270	neuron-neuron synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
enables	GO:0004952	dopamine neurotransmitter receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	F		Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0002028	regulation of sodium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0002027	regulation of heart rate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0001964	startle response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0001659	temperature homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	F		Seeded From UniProt	complete
involved_in	GO:0046717	acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
involved_in	GO:0043666	regulation of phosphoprotein phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0043408	regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0043266	regulation of potassium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	F		Seeded From UniProt	complete
involved_in	GO:0042756	drinking behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0042321	negative regulation of circadian sleep/wake cycle, sleep	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
part_of	GO:0036126	sperm flagellum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	F		Seeded From UniProt	complete
enables	GO:0035240	dopamine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	F		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0033602	negative regulation of dopamine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
involved_in	GO:0031223	auditory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
involved_in	GO:0021769	orbitofrontal cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0021756	striatum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
involved_in	GO:0014854	response to inactivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	F		Seeded From UniProt	complete
involved_in	GO:0007626	locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0007212	dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	F		Seeded From UniProt	complete
enables	GO:0004952	dopamine neurotransmitter receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	F		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0002031	G protein-coupled receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0001963	synaptic transmission, dopaminergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
part_of	GO:0001669	acrosomal vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	F		Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	C		Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	C		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	C		Seeded From UniProt	complete
part_of	GO:0098691	dopaminergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	C		Seeded From UniProt	complete
involved_in	GO:0060160	negative regulation of dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0060134	prepulse inhibition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0060124	positive regulation of growth hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0051967	negative regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0051584	regulation of dopamine uptake involved in synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0051580	regulation of neurotransmitter uptake	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0048755	branching morphogenesis of a nerve	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0048149	behavioral response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0045824	negative regulation of innate immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0043473	pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0043278	response to morphine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0043266	regulation of potassium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0042417	dopamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0040018	positive regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0035815	positive regulation of renal sodium excretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0035810	positive regulation of urine volume	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
enables	GO:0035240	dopamine binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	F		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0032228	regulation of synaptic transmission, GABAergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0030534	adult behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:0030432	peristalsis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61168 ensembl:ENSMUSP00000075170	P		Seeded From UniProt	complete
involved_in	GO:1901386	negative regulation of voltage-gated calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0099170	postsynaptic modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	C		Seeded From UniProt	complete
involved_in	GO:0090325	regulation of locomotion involved in locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0051823	regulation of synapse structural plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
	GO:1900168	positive regulation of glial cell line-derived neurotrophic factor secretion	PMID:23373701^[4]	ECO:0000314			P		Data from a chromatin immunoprecipitation assay, tehy identified a direct association of Zif268 with the GDNF promoter, and Figure 1 shows that Dopamine D2 receptor (D2R) activation increases glial cell line–derived neurotrophic factor (GDNF) mRNA and protein levels	complete CACAO 7176
involved_in	GO:0051481	negative regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
involved_in	GO:0048678	response to axon injury	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61169 ensembl:ENSRNOP00000043759	F		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	F		Seeded From UniProt	complete
enables	GO:0004952	dopamine neurotransmitter receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001922	F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276	P		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001922	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000276 InterPro:IPR001922 InterPro:IPR017452	C		Seeded From UniProt	complete
involved_in	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	PMID:1331329^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:1331329^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015459	potassium channel regulator activity	PMID:12297500^[15]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	PMID:2531656^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	PMID:1331329^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007194	negative regulation of adenylate cyclase activity	PMID:2531656^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:2531656^[16]	ECO:0000305	curator inference used in manual assertion	GO:0001591	C		Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	PMID:2531656^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901386	negative regulation of voltage-gated calcium channel activity	PMID:7921596^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	PMID:1331329^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:1331329^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	PMID:2531656^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	PMID:1331329^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007194	negative regulation of adenylate cyclase activity	PMID:2531656^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	PMID:7921596^[17]	ECO:0000305	curator inference used in manual assertion	GO:1901386	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:2531656^[16]	ECO:0000305	curator inference used in manual assertion	GO:0001591	C		Seeded From UniProt	complete
enables	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	PMID:2531656^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-390846 Reactome:R-HSA-380073	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P		Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Likhite, N et al. (2015) The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling. Sci Signal 8 ra115 PubMed GONUTS page
↑ ^2.0 ^2.1 Beaulieu, JM (2012) A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci 37 7-16 PubMed GONUTS page
↑ ^3.0 ^3.1 Marley, A & von Zastrow, M (2010) DISC1 regulates primary cilia that display specific dopamine receptors. PLoS ONE 5 e10902 PubMed GONUTS page
↑ ^4.0 ^4.1 Ahmadiantehrani, S & Ron, D (2013) Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J. Neurochem. 125 193-204 PubMed GONUTS page
↑ Zhang, X et al. (2012) G protein-coupled receptors participate in cytokinesis. Cytoskeleton (Hoboken) 69 810-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Freedman, SB et al. (1994) Expression and pharmacological characterization of the human D3 dopamine receptor. J. Pharmacol. Exp. Ther. 268 417-26 PubMed GONUTS page
↑ ^7.0 ^7.1 Zarei, S et al. (2006) Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors. J. Thromb. Haemost. 4 1588-95 PubMed GONUTS page
↑ Robinson, SW & Caron, MG (1996) Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells. J. Neurochem. 67 212-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Seeman, P et al. (1993) Dopamine D4 receptors elevated in schizophrenia. Nature 365 441-5 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Rashid, AJ et al. (2007) D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc. Natl. Acad. Sci. U.S.A. 104 654-9 PubMed GONUTS page
↑ Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
↑ Guo, W et al. (2008) Dopamine D2 receptors form higher order oligomers at physiological expression levels. EMBO J. 27 2293-304 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Liu, YF et al. (1992) Differential sensitivity of the short and long human dopamine D2 receptor subtypes to protein kinase C. J. Neurochem. 59 2311-7 PubMed GONUTS page
↑ Lavine, N et al. (2002) G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. J. Biol. Chem. 277 46010-9 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 Dal Toso, R et al. (1989) The dopamine D2 receptor: two molecular forms generated by alternative splicing. EMBO J. 8 4025-34 PubMed GONUTS page
↑ ^17.0 ^17.1 Seabrook, GR et al. (1994) Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors. Br. J. Pharmacol. 112 728-34 PubMed GONUTS page

[PMID:26554819-1] 1.0 ^1.1 Likhite, N et al. (2015) The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling. Sci Signal 8 ra115 PubMed GONUTS page

[PMID:21711983-2] 2.0 ^2.1 Beaulieu, JM (2012) A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci 37 7-16 PubMed GONUTS page

[PMID:20531939-3] 3.0 ^3.1 Marley, A & von Zastrow, M (2010) DISC1 regulates primary cilia that display specific dopamine receptors. PLoS ONE 5 e10902 PubMed GONUTS page

[PMID:23373701-4] 4.0 ^4.1 Ahmadiantehrani, S & Ron, D (2013) Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J. Neurochem. 125 193-204 PubMed GONUTS page

[PMID:22888021-5] Zhang, X et al. (2012) G protein-coupled receptors participate in cytokinesis. Cytoskeleton (Hoboken) 69 810-8 PubMed GONUTS page

[PMID:8301582-6] 6.0 ^6.1 ^6.2 ^6.3 Freedman, SB et al. (1994) Expression and pharmacological characterization of the human D3 dopamine receptor. J. Pharmacol. Exp. Ther. 268 417-26 PubMed GONUTS page

[PMID:16839358-7] 7.0 ^7.1 Zarei, S et al. (2006) Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors. J. Thromb. Haemost. 4 1588-95 PubMed GONUTS page

[PMID:8666994-8] Robinson, SW & Caron, MG (1996) Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells. J. Neurochem. 67 212-9 PubMed GONUTS page

[PMID:8413587-9] 9.0 ^9.1 Seeman, P et al. (1993) Dopamine D4 receptors elevated in schizophrenia. Nature 365 441-5 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17194762-11] Rashid, AJ et al. (2007) D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc. Natl. Acad. Sci. U.S.A. 104 654-9 PubMed GONUTS page

[PMID:28154160-12] Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page

[PMID:18668123-13] Guo, W et al. (2008) Dopamine D2 receptors form higher order oligomers at physiological expression levels. EMBO J. 27 2293-304 PubMed GONUTS page

[PMID:1331329-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Liu, YF et al. (1992) Differential sensitivity of the short and long human dopamine D2 receptor subtypes to protein kinase C. J. Neurochem. 59 2311-7 PubMed GONUTS page

[PMID:12297500-15] Lavine, N et al. (2002) G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. J. Biol. Chem. 277 46010-9 PubMed GONUTS page

[PMID:2531656-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 Dal Toso, R et al. (1989) The dopamine D2 receptor: two molecular forms generated by alternative splicing. EMBO J. 8 4025-34 PubMed GONUTS page

[PMID:7921596-17] 17.0 ^17.1 Seabrook, GR et al. (1994) Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors. Br. J. Pharmacol. 112 728-34 PubMed GONUTS page

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