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DANRE:Q20CG4

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) nrg1 (ECO:0000313 with ZFIN:ZDB-GENE-050302-113)
Protein Name(s) Neuregulin (ECO:0000313 with EMBL:ABC94864.1)
External Links
UniProt Q20CG4
EMBL DQ366108
UniGene Dr.133124
ProteinModelPortal Q20CG4
ZFIN ZDB-GENE-050302-113
HOGENOM HOG000273863
HOVERGEN HBG006531
NextBio 20932619
GO GO:0009790
Gene3D 2.60.40.10
InterPro IPR000742
IPR013032
IPR007110
IPR013783
IPR013098
IPR002154
IPR018250
PANTHER PTHR11100:SF7
Pfam PF12661
PF07679
PF02158
SMART SM00181
PROSITE PS00022
PS01186
PS50026
PS50835

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0036135

Schwann cell migration

PMID:21965611[1]

IMP: Inferred from Mutant Phenotype

P

Perlin et al. used anti-sense MOs to knockdown neuregulin expression, and Figure 1 shows that in zebrafish morphants, there was a reduction of Schwann cells occupying the PLLn.

complete
CACAO 8085

GO:0060347

heart trabecula formation

PMID:21246662[2]

IMP: Inferred from Mutant Phenotype

P

Figure 5: The authors used AG1748 to block ErbB4/neuregulin interaction in zebrafish embryos, thereby phenocopying loss of neuregulin signaling (control: DMSO injection).

complete
CACAO 8100

GO:0005102

receptor binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002154

F

Seeded From UniProt

complete

GO:0009790

embryo development

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002154

P

Seeded From UniProt

complete

GO:0036135

Schwann cell migration

PMID:21965611[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060347

heart trabecula formation

PMID:21246662[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Perlin, JR et al. (2011) Neuronal Neuregulin 1 type III directs Schwann cell migration. Development 138 4639-48 PubMed GONUTS page
  2. 2.0 2.1 Peshkovsky, C et al. (2011) Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish. Dev. Dyn. 240 446-56 PubMed GONUTS page