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DANRE:Q20CG4
Contents
| Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
| Gene Name(s) | nrg1 (ECO:0000313 with ZFIN:ZDB-GENE-050302-113) | |
| Protein Name(s) | Neuregulin (ECO:0000313 with EMBL:ABC94864.1) | |
| External Links | ||
| UniProt | Q20CG4 | |
| EMBL | DQ366108 | |
| UniGene | Dr.133124 | |
| ProteinModelPortal | Q20CG4 | |
| ZFIN | ZDB-GENE-050302-113 | |
| HOGENOM | HOG000273863 | |
| HOVERGEN | HBG006531 | |
| NextBio | 20932619 | |
| GO | GO:0009790 | |
| Gene3D | 2.60.40.10 | |
| InterPro | IPR000742 IPR013032 IPR007110 IPR013783 IPR013098 IPR002154 IPR018250 | |
| PANTHER | PTHR11100:SF7 | |
| Pfam | PF12661 PF07679 PF02158 | |
| SMART | SM00181 | |
| PROSITE | PS00022 PS01186 PS50026 PS50835 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0036135 |
Schwann cell migration |
ECO:0000315 |
P |
Perlin et al. used anti-sense MOs to knockdown neuregulin expression, and Figure 1 shows that in zebrafish morphants, there was a reduction of Schwann cells occupying the PLLn. |
complete | |||||
| GO:0060347 |
heart trabecula formation |
ECO:0000315 |
P |
Figure 5: The authors used AG1748 to block ErbB4/neuregulin interaction in zebrafish embryos, thereby phenocopying loss of neuregulin signaling (control: DMSO injection). |
complete | |||||
|
involved_in |
GO:0060347 |
heart trabecula formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036135 |
Schwann cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060959 |
cardiac neuron development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-180709-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048699 |
generation of neurons |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-151007-4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048699 |
generation of neurons |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-151007-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048484 |
enteric nervous system development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-170808-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0036135 |
Schwann cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-120309-6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031101 |
fin regeneration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-081222-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021778 |
oligodendrocyte cell fate specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-081222-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021755 |
eurydendroid cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-081222-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014044 |
Schwann cell development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-120309-6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007422 |
peripheral nervous system development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-081222-3 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003222 |
ventricular trabecula myocardium morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-GENO-180709-6 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001755 |
neural crest cell migration |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-081219-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1097165 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000873337 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000873337 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Perlin, JR et al. (2011) Neuronal Neuregulin 1 type III directs Schwann cell migration. Development 138 4639-48 PubMed GONUTS page
- ↑ 2.0 2.1 Peshkovsky, C et al. (2011) Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish. Dev. Dyn. 240 446-56 PubMed GONUTS page
- ↑ 3.0 3.1 Brown, D et al. (2018) Neuregulin-1 is essential for nerve plexus formation during cardiac maturation. J. Cell. Mol. Med. 22 2007-2017 PubMed GONUTS page
- ↑ 4.0 4.1 Sato, T et al. (2015) Neuregulin 1 Type II-ErbB Signaling Promotes Cell Divisions Generating Neurons from Neural Progenitor Cells in the Developing Zebrafish Brain. PLoS ONE 10 e0127360 PubMed GONUTS page
- ↑ Pu, J et al. (2017) Neuregulin 1 is involved in enteric nervous system development in zebrafish. J. Pediatr. Surg. 52 1182-1187 PubMed GONUTS page
- ↑ Rojas-Muñoz, A et al. (2009) ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration. Dev. Biol. 327 177-90 PubMed GONUTS page
- ↑ 7.0 7.1 Wood, JD et al. (2009) Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain. Hum. Mol. Genet. 18 391-404 PubMed GONUTS page
- ↑ Lush, ME & Piotrowski, T (2014) ErbB expressing Schwann cells control lateral line progenitor cells via non-cell-autonomous regulation of Wnt/β-catenin. Elife 3 e01832 PubMed GONUTS page
- ↑ 9.0 9.1 Honjo, Y et al. (2008) Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons. Development 135 2615-25 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
