GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:24642408

From GONUTS
Jump to: navigation, search
Citation

Lush, ME and Piotrowski, T (2014) ErbB expressing Schwann cells control lateral line progenitor cells via non-cell-autonomous regulation of Wnt/β-catenin. Elife 3:e01832

Abstract

Proper orchestration of quiescence and activation of progenitor cells is crucial during embryonic development and adult homeostasis. We took advantage of the zebrafish sensory lateral line to define niche-progenitor interactions to understand how integration of diverse signaling pathways spatially and temporally regulates the coordination of these processes. Our previous studies demonstrated that Schwann cells play a crucial role in negatively regulating lateral line progenitor proliferation. Here we demonstrate that ErbB/Neuregulin signaling is not only required for Schwann cell migration but that it plays a continued role in postmigratory Schwann cells. ErbB expressing Schwann cells inhibit lateral line progenitor proliferation and differentiation through non-cell-autonomous inhibition of Wnt/β-catenin signaling. Subsequent activation of Fgf signaling controls sensory organ differentiation, but not progenitor proliferation. In addition to the lateral line, these findings have important implications for understanding how niche-progenitor cells segregate interactions during development, and how they may go wrong in disease states. DOI: http://dx.doi.org/10.7554/eLife.01832.001.

Links

PubMed PMC3957165 Online version:10.7554/eLife.01832

Keywords

Animals; Animals, Genetically Modified; Cell Communication/drug effects; Cell Differentiation; Cell Proliferation; ErbB Receptors/antagonists & inhibitors; ErbB Receptors/genetics; ErbB Receptors/metabolism; Fibroblast Growth Factors/metabolism; Gene Expression Regulation, Developmental; Genotype; Lateral Line System/cytology; Lateral Line System/drug effects; Lateral Line System/metabolism; Mutation; Neural Stem Cells/drug effects; Neural Stem Cells/metabolism; Neuregulins/metabolism; Phenotype; Protein Kinase Inhibitors/pharmacology; Receptors, Notch/metabolism; Schwann Cells/drug effects; Schwann Cells/metabolism; Stem Cell Niche; Time Factors; Wnt Signaling Pathway/drug effects; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism; beta Catenin/genetics; beta Catenin/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:A0A0R4IBM0

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120309-6

P

Seeded From UniProt

complete

DANRE:A0A0R4IDP7

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120309-6

P

Seeded From UniProt

complete

DANRE:A0A0R4IFE6

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120309-6

P

Seeded From UniProt

complete

DANRE:A0A0R4IPH3

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120309-6

P

Seeded From UniProt

complete

DANRE:A0A1B4Z255

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120309-6

P

Seeded From UniProt

complete

DANRE:B3DK99

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120309-6

P

Seeded From UniProt

complete

DANRE:B9VQK7

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120309-6

P

Seeded From UniProt

complete

DANRE:B9VQK8

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120309-6

P

Seeded From UniProt

complete

DANRE:B9VQK9

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120309-6

P

Seeded From UniProt

complete

DANRE:B9VQL0

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120309-6

P

Seeded From UniProt

complete

DANRE:Q20CG4

involved_in

GO:0014044: Schwann cell development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-120309-6

P

Seeded From UniProt

complete

Notes

See also

References

See Help:References for how to manage references in GONUTS.