User:Mkelly

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
acceptable	CHICK:Q4PLA5	2013-03-28 21:09:16 CDT	GO:0010592 positive regulation of lamellipodium assembly (P)	PMID:16912080	ECO:0000315 mutant phenotype evidence used in manual assertion	Expression of dominant negative ErbB4 mutant inhibited extension of leading process on rhombic lip (Figure 7)	challenge
acceptable	XENLA:Q153D9	2013-03-28 21:51:46 CDT	GO:0060031 mediolateral intercalation (P)	PMID:17134691	ECO:0000315 mutant phenotype evidence used in manual assertion	Generated mutant ErbB4 receptors (truncated receptors) performed in vitro explant assay to understand if ErbB signaling is involved in regulation of head mesoderm migration (Figure 6)	challenge
acceptable	CHICK:Q4PLA5	2013-03-31 16:21:16 CDT	GO:0051491 positive regulation of filopodium assembly (P)	PMID:16912080	ECO:0000315 mutant phenotype evidence used in manual assertion	Expression of dominant negative ErbB4 mutant inhibited extension of leading process on rhombic lip (Figure 7)	challenge
updatedbyinstructor	DANRE:Q20CG4	2013-04-14 17:30:30 CDT	GO:0036135 Schwann cell migration (P)	PMID:21965611	ECO:0000315 mutant phenotype evidence used in manual assertion	Perlin et al. used anti-sense MOs to knockdown neuregulin expression, and Figure 1 shows that in zebrafish morphants, there was a reduction of Schwann cells occupying the PLLn.	challenge
acceptable	DANRE:Q20CG4	2013-04-14 17:36:10 CDT	GO:0060347 heart trabecula formation (P)	PMID:21246662	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 5: The authors used AG1748 to block ErbB4/neuregulin interaction in zebrafish embryos, thereby phenocopying loss of neuregulin signaling (control: DMSO injection).	challenge

acceptable:4
unacceptable:0
requires_changes:0
flagged:0

Annotations challenged by Mkelly

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
updatedbyinstructor	Dylandekalb, Team Higgs BROsons	MOUSE:LIS1	GO:0061003 - positive regulation of dendritic spine morphogenesis (P)	PMID:23483716	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 1 fixed by Mkelly
updatedbyinstructor	Samtaylor, Team Do It, You Won't	RAT:PYC	GO:0071073 - positive regulation of phospholipid biosynthetic process (P)	PMID:23357280	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 1 fixed by Mkelly
requireschanges	Samtaylor, Team Do It, You Won't	MOUSE:DACH1	GO:0043433 - negative regulation of DNA-binding transcription factor activity (P)	PMID:16980615	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 2

2 annotations fixed by Mkelly

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