MOUSE:LIS1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pafah1b1 (synonyms: Lis-1, Lis1, Pafaha)
Protein Name(s)	Platelet-activating factor acetylhydrolase IB subunit alpha (ECO:0000255 with HAMAP-Rule:MF_03141) Lissencephaly-1 protein (ECO:0000255 with HAMAP-Rule:MF_03141) LIS-1 (ECO:0000255 with HAMAP-Rule:MF_03141) PAF acetylhydrolase 45 kDa subunit (ECO:0000255 with HAMAP-Rule:MF_03141) PAF-AH 45 kDa subunit (ECO:0000255 with HAMAP-Rule:MF_03141) PAF-AH alpha (ECO:0000255 with HAMAP-Rule:MF_03141) PAFAH alpha (ECO:0000255 with HAMAP-Rule:MF_03141)
External Links
UniProt	P63005
EMBL	U95116 U95120 U95119 U95120 U95119 L25109 AY189217 AY189218 BC014831 BC026141
CCDS	CCDS25035.1
RefSeq	NP_038653.1
UniGene	Mm.397111
PDB	1UUJ 1VYH
PDBsum	1UUJ 1VYH
ProteinModelPortal	P63005
SMR	P63005
BioGrid	202013
DIP	DIP-29555N
IntAct	P63005
MINT	MINT-267632
PhosphoSite	P63005
REPRODUCTION-2DPAGE	P63005
MaxQB	P63005
PaxDb	P63005
PRIDE	P63005
Ensembl	ENSMUST00000021091 ENSMUST00000102520
GeneID	18472
KEGG	mmu:18472
UCSC	uc007kce.2
CTD	5048
MGI	MGI:109520
eggNOG	COG2319
HOGENOM	HOG000184015
HOVERGEN	HBG006271
InParanoid	P63005
KO	K16794
OMA	MKTLYAH
OrthoDB	EOG7QZG9N
PhylomeDB	P63005
TreeFam	TF105741
Reactome	REACT_196635 REACT_198961 REACT_207679 REACT_243078 REACT_244487 REACT_245720 REACT_256756
ChiTaRS	Pafah1b1
EvolutionaryTrace	P63005
NextBio	294162
PRO	PR:P63005
Proteomes	UP000000589
Bgee	P63005
ExpressionAtlas	P63005
Genevestigator	P63005
GO	GO:0000235 GO:0030424 GO:0005938 GO:0005813 GO:0005737 GO:0005829 GO:0070062 GO:0030426 GO:0005871 GO:0000776 GO:0005875 GO:0015630 GO:0031512 GO:0043025 GO:0005635 GO:0031965 GO:0048471 GO:0008017 GO:0051219 GO:0042803 GO:0001675 GO:0030036 GO:0008344 GO:0001667 GO:0048854 GO:0016477 GO:0021987 GO:0021895 GO:0021540 GO:0051660 GO:0000132 GO:0021766 GO:0021819 GO:0007611 GO:0016042 GO:0000226 GO:0031023 GO:0007067 GO:0046329 GO:0010977 GO:0007405 GO:0050885 GO:0001764 GO:0051081 GO:0007097 GO:0036035 GO:0045773 GO:0001961 GO:0045931 GO:0009306 GO:0032319 GO:0008090 GO:0017145 GO:0007268 GO:0019226 GO:0047496
Gene3D	2.130.10.10
HAMAP	MF_03141
InterPro	IPR017252 IPR020472 IPR006594 IPR013720 IPR015943 IPR001680 IPR019775 IPR017986
Pfam	PF08513 PF00400
PIRSF	PIRSF037647
PRINTS	PR00320
SMART	SM00667 SM00320
SUPFAM	SSF50978
PROSITE	PS50896 PS00678 PS50082 PS50294

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0061003	positive regulation of dendritic spine morphogenesis	PMID:23483716^[1]	ECO:0000315			P		Figure 4	complete CACAO 6967
	GO:0044419	interspecies interaction between organisms	PMID:23483716^[1]	ECO:0000315			P		Figure 6 - In the experiment it showed that Lis1+/− mutant mice exhibit asocial behaviour in a 3-chamber social interaction test. Whenever the mice had the wt gene they interacted normally but with the Lis1+/- they were much more antisocial; showing that Lis1 is involved with interspecies interaction.	complete CACAO 6970
	GO:0090176	microtubule cytoskeleton organization involved in establishment of planar polarity	PMID:23533177^[2]	ECO:0000315			P		Figure 2	complete CACAO 7252
	GO:0042249	establishment of planar polarity of embryonic epithelium	PMID:23533177^[2]	ECO:0000315			P		Figure 2	complete CACAO 7253
	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:23533177^[2]	ECO:0000315			P		Figure 2 & 7.	complete CACAO 7254
	GO:0060117	auditory receptor cell development	PMID:23533177^[2]	ECO:0000315			P		Fig 3C,D. "Moreover, the apical surfaces of both hair cells and supporting cells in Lis1cKO-early cochleae were misshapen. Many hair cells adopted an oblong or irregular shape and the evenly spaced ‘hourglass’ shape of supporting cell apical domains was frequently jumbled and distorted (Fig. 3B)... the Lis1cKO-early sensory epithelium was disorganized, with hair cell nuclei frequently found at varying distances from the luminal surface (Fig. 3D). And Fig 8.	complete CACAO 7255
	GO:0040019	positive regulation of embryonic development	PMID:23533177^[2]	ECO:0000315			P		Figure 2	complete CACAO 7256
	GO:0051130	positive regulation of cellular component organization	PMID:23533177^[2]	ECO:0000315			P		Figure 3 - "Lis1 regulates cellular organization and junctional nectin localization in the organ of Corti"	complete CACAO 7257
	GO:0090102	cochlea development	PMID:23533177^[2]	ECO:0000315			P		Figure 3 - "Lis1 regulates cellular organization and junctional nectin localization in the organ of Corti."	complete CACAO 7258
	GO:0043622	cortical microtubule organization	PMID:21844209^[3]	ECO:0000315			P		Figure 4	complete CACAO 7259
	GO:0002934	desmosome organization	PMID:21844209^[3]	ECO:0000315			P		Figure 6	complete CACAO 7297
involved_in	GO:0043622	cortical microtubule organization	PMID:21844209^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090102	cochlea development	PMID:23533177^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051130	positive regulation of cellular component organization	PMID:23533177^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040019	positive regulation of embryonic development	PMID:23533177^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060117	auditory receptor cell development	PMID:23533177^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:23533177^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042249	establishment of planar polarity of embryonic epithelium	PMID:23533177^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090176	microtubule cytoskeleton organization involved in establishment of planar polarity	PMID:23533177^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061003	positive regulation of dendritic spine morphogenesis	PMID:23483716^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000574	regulation of microtubule motor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000752736 UniProtKB:Q00664	P		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015754 PANTHER:PTN000752736 UniProtKB:P43033 UniProtKB:P43034	F		Seeded From UniProt	complete
enables	GO:0051010	microtubule plus-end binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000752736 SGD:S000005795	F		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000522053 UniProtKB:P43034 ZFIN:ZDB-GENE-040116-2 ZFIN:ZDB-GENE-040116-3	P		Seeded From UniProt	complete
involved_in	GO:0047496	vesicle transport along microtubule	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109520 PANTHER:PTN000752736	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015754 PANTHER:PTN000522053 RGD:620331	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000522053 RGD:620331	C		Seeded From UniProt	complete
involved_in	GO:0031023	microtubule organizing center organization	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000752736 UniProtKB:P43034	P		Seeded From UniProt	complete
involved_in	GO:0008090	retrograde axonal transport	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015754 MGI:MGI:109520 PANTHER:PTN000522053	P		Seeded From UniProt	complete
involved_in	GO:0007097	nuclear migration	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015754 PANTHER:PTN000752736 RGD:620331 UniProtKB:Q00664	P		Seeded From UniProt	complete
part_of	GO:0005881	cytoplasmic microtubule	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000752736 SGD:S000005795	C		Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109520 PANTHER:PTN000752736 UniProtKB:P43034	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000752736 RGD:620331 UniProtKB:P43034	C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015754 PANTHER:PTN000752736 UniProtKB:P43034 WB:WBGene00003047	C		Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000752736 UniProtKB:P43034 WB:WBGene00003047	P		Seeded From UniProt	complete
part_of	GO:0090724	central region of growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	C		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051661	maintenance of centrosome location	PMID:23533177^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384060	P	occurs_in:(CL:0000589) occurs_in:(EMAPA:19061)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051660	establishment of centrosome localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	PMID:14578885^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P97318	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051081	nuclear envelope disassembly	PMID:18809722^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050885	neuromuscular process controlling balance	PMID:10541472^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050885	neuromuscular process controlling balance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048854	brain morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:14578885^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0047496	vesicle transport along microtubule	PMID:16107726^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1914453 MGI:MGI:1932915	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046329	negative regulation of JNK cascade	PMID:22073305^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1100089	P	regulates_o_occurs_in:(CL:0000092)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045773	positive regulation of axon extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	P		Seeded From UniProt	complete
enables	GO:0045505	dynein intermediate chain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043087	regulation of GTPase activity	PMID:14507966^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:11344260^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63005	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036035	osteoclast development	PMID:22073305^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(CL:0000092)	Seeded From UniProt	complete
part_of	GO:0032420	stereocilium	PMID:23533177^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000589) part_of:(EMAPA:17597)	Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	C		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	PMID:17314247^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16853) part_of:(CL:0000307)\|part_of:(EMAPA:29043) part_of:(CL:0000067)	Seeded From UniProt	complete
colocalizes_with	GO:0031252	cell leading edge	PMID:14691133^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031023	microtubule organizing center organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030036	actin cytoskeleton organization	PMID:14507966^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	PMID:18469343^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1914453	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	PMID:11344260^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387783	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021895	cerebral cortex neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021819	layer formation in cerebral cortex	PMID:17330141^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1340044	P	has_participant:(EMAPA:35588)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021766	hippocampus development	PMID:17330141^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1340044	P	results_in_development_of:(EMAPA:32845)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021766	hippocampus development	PMID:10729324^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021540	corpus callosum morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019226	transmission of nerve impulse	PMID:17433713^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2387783	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017145	stem cell division	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:12629176^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	PMID:13129914^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000018)	Seeded From UniProt	complete
colocalizes_with	GO:0015630	microtubule cytoskeleton	PMID:17314247^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009306	protein secretion	PMID:22073305^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000092)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:10541472^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008090	retrograde axonal transport	PMID:11163259^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:11163259^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43033	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	PMID:10541472^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007405	neuroblast proliferation	PMID:12629176^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	PMID:10729324^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007097	nuclear migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007017	microtubule-based process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	C		Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	PMID:11163259^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	C		Seeded From UniProt	complete
part_of	GO:0005871	kinesin complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:11163260^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:11163259^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12950100^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12551946^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:18809722^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63004	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001961	positive regulation of cytokine-mediated signaling pathway	PMID:22073305^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:16107726^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1932915	P	results_in_movement_of:(CL:0000120)\|occurs_in(EMAPA:19039) results_in_movement_of:(CL:0000598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:12796778^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:894689	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:9697693^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:15331402^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P	occurs_in:(EMAPA:16910) results_in_movement_of:(CL:0000498)\|occurs_in(EMAPA:16910) results_in_movement_of:(CL:0000402)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:14507966^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2384054	P	results_in_movement_of:(CL:0000120)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620331	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001675	acrosome assembly	PMID:13129914^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2683481	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001667	ameboidal-type cell migration	PMID:22073305^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_movement_of:(CL:0000092)	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	C		Seeded From UniProt	complete
part_of	GO:0000235	astral microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000226	microtubule cytoskeleton organization	PMID:16107726^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1932915	P	occurs_in:(EMAPA:19039) occurs_in:(CL:0000117)\|occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000226	microtubule cytoskeleton organization	PMID:22073305^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000091)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000132	establishment of mitotic spindle orientation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43034	P		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008090	C		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008090	C		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	F		Seeded From UniProt	complete
involved_in	GO:0050885	neuromuscular process controlling balance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	P		Seeded From UniProt	complete
involved_in	GO:0031023	microtubule organizing center organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	P		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	P		Seeded From UniProt	complete
involved_in	GO:0021540	corpus callosum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	P		Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	P		Seeded From UniProt	complete
involved_in	GO:0007017	microtubule-based process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	C		Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	C		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	P		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	C		Seeded From UniProt	complete
part_of	GO:0000235	astral microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	C		Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43034 ensembl:ENSP00000380378	P		Seeded From UniProt	complete
part_of	GO:0090724	central region of growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	C		Seeded From UniProt	complete
involved_in	GO:0051660	establishment of centrosome localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	P		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	P		Seeded From UniProt	complete
involved_in	GO:0045773	positive regulation of axon extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	P		Seeded From UniProt	complete
enables	GO:0045505	dynein intermediate chain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	F		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	C		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	C		Seeded From UniProt	complete
involved_in	GO:0021895	cerebral cortex neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	P		Seeded From UniProt	complete
involved_in	GO:0017145	stem cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	P		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	P		Seeded From UniProt	complete
involved_in	GO:0007097	nuclear migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	P		Seeded From UniProt	complete
part_of	GO:0005871	kinesin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	C		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63004 ensembl:ENSRNOP00000003696	P		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107004	F		Seeded From UniProt	complete
involved_in	GO:0000132	establishment of mitotic spindle orientation	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107004	P		Seeded From UniProt	complete
involved_in	GO:0051012	microtubule sliding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107004	P		Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107004	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107004	P		Seeded From UniProt	complete
involved_in	GO:0007017	microtubule-based process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107004	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107004	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0442	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Sudarov, A et al. (2013) Lis1 controls dynamics of neuronal filopodia and spines to impact synaptogenesis and social behaviour. EMBO Mol Med 5 591-607 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 Sipe, CW et al. (2013) Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization. Development 140 1785-95 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Sumigray, KD et al. (2011) Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. J. Cell Biol. 194 631-42 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Assadi, AH et al. (2003) Interaction of reelin signaling and Lis1 in brain development. Nat. Genet. 35 270-6 PubMed GONUTS page
↑ ^6.0 ^6.1 Hebbar, S et al. (2008) Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells. J. Cell Biol. 182 1063-71 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Paylor, R et al. () Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice. Learn. Mem. 6 521-37 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Sasaki, S et al. (2005) Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol. Cell. Biol. 25 7812-27 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Ye, S et al. (2011) LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. PLoS ONE 6 e27285 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Kholmanskikh, SS et al. (2003) Disregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neurons. J. Neurosci. 23 8673-81 PubMed GONUTS page
↑ ^11.0 ^11.1 Cahana, A et al. (2001) Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization. Proc. Natl. Acad. Sci. U.S.A. 98 6429-34 PubMed GONUTS page
↑ ^12.0 ^12.1 Pedersen, LB et al. (2007) The lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein for targeting to Chlamydomonas flagella. J. Cell. Sci. 120 858-67 PubMed GONUTS page
↑ Dujardin, DL et al. (2003) A role for cytoplasmic dynein and LIS1 in directed cell movement. J. Cell Biol. 163 1205-11 PubMed GONUTS page
↑ Pawlisz, AS et al. (2008) Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination. Hum. Mol. Genet. 17 2441-55 PubMed GONUTS page
↑ ^15.0 ^15.1 Zhang, G et al. (2007) The Pafah1b complex interacts with the reelin receptor VLDLR. PLoS ONE 2 e252 PubMed GONUTS page
↑ ^16.0 ^16.1 Fleck, MW et al. (2000) Hippocampal abnormalities and enhanced excitability in a murine model of human lissencephaly. J. Neurosci. 20 2439-50 PubMed GONUTS page
↑ Valdés-Sánchez, L et al. (2007) Postnatal alterations of the inhibitory synaptic responses recorded from cortical pyramidal neurons in the Lis1/sLis1 mutant mouse. Mol. Cell. Neurosci. 35 220-9 PubMed GONUTS page
↑ ^18.0 ^18.1 Gambello, MJ et al. (2003) Multiple dose-dependent effects of Lis1 on cerebral cortical development. J. Neurosci. 23 1719-29 PubMed GONUTS page
↑ ^19.0 ^19.1 Nayernia, K et al. (2003) Inactivation of a testis-specific Lis1 transcript in mice prevents spermatid differentiation and causes male infertility. J. Biol. Chem. 278 48377-85 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Sasaki, S et al. (2000) A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron 28 681-96 PubMed GONUTS page
↑ Niethammer, M et al. (2000) NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron 28 697-711 PubMed GONUTS page
↑ Cahana, A et al. (2003) A study of the nature of embryonic lethality in LIS1-/- mice. Mol. Reprod. Dev. 66 134-42 PubMed GONUTS page
↑ Koizumi, H et al. (2003) Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis. J. Biol. Chem. 278 12489-94 PubMed GONUTS page
↑ Toyo-oka, K et al. (2003) 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat. Genet. 34 274-85 PubMed GONUTS page
↑ Hirotsune, S et al. (1998) Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. Nat. Genet. 19 333-9 PubMed GONUTS page
↑ McManus, MF et al. (2004) Lis1 is necessary for normal non-radial migration of inhibitory interneurons. Am. J. Pathol. 165 775-84 PubMed GONUTS page

[PMID:23483716-1] 1.0 ^1.1 ^1.2 Sudarov, A et al. (2013) Lis1 controls dynamics of neuronal filopodia and spines to impact synaptogenesis and social behaviour. EMBO Mol Med 5 591-607 PubMed GONUTS page

[PMID:23533177-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 Sipe, CW et al. (2013) Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization. Development 140 1785-95 PubMed GONUTS page

[PMID:21844209-3] 3.0 ^3.1 ^3.2 Sumigray, KD et al. (2011) Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. J. Cell Biol. 194 631-42 PubMed GONUTS page

[PMID:21873635-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14578885-5] 5.0 ^5.1 Assadi, AH et al. (2003) Interaction of reelin signaling and Lis1 in brain development. Nat. Genet. 35 270-6 PubMed GONUTS page

[PMID:18809722-6] 6.0 ^6.1 Hebbar, S et al. (2008) Lis1 and Ndel1 influence the timing of nuclear envelope breakdown in neural stem cells. J. Cell Biol. 182 1063-71 PubMed GONUTS page

[PMID:10541472-7] 7.0 ^7.1 ^7.2 Paylor, R et al. () Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice. Learn. Mem. 6 521-37 PubMed GONUTS page

[PMID:16107726-8] 8.0 ^8.1 ^8.2 Sasaki, S et al. (2005) Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol. Cell. Biol. 25 7812-27 PubMed GONUTS page

[PMID:22073305-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Ye, S et al. (2011) LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. PLoS ONE 6 e27285 PubMed GONUTS page

[PMID:14507966-10] 10.0 ^10.1 ^10.2 Kholmanskikh, SS et al. (2003) Disregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neurons. J. Neurosci. 23 8673-81 PubMed GONUTS page

[PMID:11344260-11] 11.0 ^11.1 Cahana, A et al. (2001) Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization. Proc. Natl. Acad. Sci. U.S.A. 98 6429-34 PubMed GONUTS page

[PMID:17314247-12] 12.0 ^12.1 Pedersen, LB et al. (2007) The lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein for targeting to Chlamydomonas flagella. J. Cell. Sci. 120 858-67 PubMed GONUTS page

[PMID:14691133-13] Dujardin, DL et al. (2003) A role for cytoplasmic dynein and LIS1 in directed cell movement. J. Cell Biol. 163 1205-11 PubMed GONUTS page

[PMID:18469343-14] Pawlisz, AS et al. (2008) Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination. Hum. Mol. Genet. 17 2441-55 PubMed GONUTS page

[PMID:17330141-15] 15.0 ^15.1 Zhang, G et al. (2007) The Pafah1b complex interacts with the reelin receptor VLDLR. PLoS ONE 2 e252 PubMed GONUTS page

[PMID:10729324-16] 16.0 ^16.1 Fleck, MW et al. (2000) Hippocampal abnormalities and enhanced excitability in a murine model of human lissencephaly. J. Neurosci. 20 2439-50 PubMed GONUTS page

[PMID:17433713-17] Valdés-Sánchez, L et al. (2007) Postnatal alterations of the inhibitory synaptic responses recorded from cortical pyramidal neurons in the Lis1/sLis1 mutant mouse. Mol. Cell. Neurosci. 35 220-9 PubMed GONUTS page

[PMID:12629176-18] 18.0 ^18.1 Gambello, MJ et al. (2003) Multiple dose-dependent effects of Lis1 on cerebral cortical development. J. Neurosci. 23 1719-29 PubMed GONUTS page

[PMID:13129914-19] 19.0 ^19.1 Nayernia, K et al. (2003) Inactivation of a testis-specific Lis1 transcript in mice prevents spermatid differentiation and causes male infertility. J. Biol. Chem. 278 48377-85 PubMed GONUTS page

[PMID:11163259-20] 20.0 ^20.1 ^20.2 ^20.3 Sasaki, S et al. (2000) A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron 28 681-96 PubMed GONUTS page

[PMID:11163260-21] Niethammer, M et al. (2000) NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron 28 697-711 PubMed GONUTS page

[PMID:12950100-22] Cahana, A et al. (2003) A study of the nature of embryonic lethality in LIS1-/- mice. Mol. Reprod. Dev. 66 134-42 PubMed GONUTS page

[PMID:12551946-23] Koizumi, H et al. (2003) Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis. J. Biol. Chem. 278 12489-94 PubMed GONUTS page

[PMID:12796778-24] Toyo-oka, K et al. (2003) 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat. Genet. 34 274-85 PubMed GONUTS page

[PMID:9697693-25] Hirotsune, S et al. (1998) Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. Nat. Genet. 19 333-9 PubMed GONUTS page

[PMID:15331402-26] McManus, MF et al. (2004) Lis1 is necessary for normal non-radial migration of inhibitory interneurons. Am. J. Pathol. 165 775-84 PubMed GONUTS page

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