GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:DACH1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Dach1 (synonyms: Dach) | |
| Protein Name(s) | Dachshund homolog 1
Dach1 | |
| External Links | ||
| UniProt | Q9QYB2 | |
| EMBL | AF102547 AF090436 AF090437 AF129510 BC141130 AK053594 AK047409 AJ005669 | |
| CCDS | CCDS36993.1 CCDS36994.1 | |
| RefSeq | NP_001033699.1 NP_031852.1 | |
| UniGene | Mm.320593 | |
| ProteinModelPortal | Q9QYB2 | |
| SMR | Q9QYB2 | |
| BioGrid | 199044 | |
| IntAct | Q9QYB2 | |
| MINT | MINT-4092795 | |
| PhosphoSite | Q9QYB2 | |
| MaxQB | Q9QYB2 | |
| PaxDb | Q9QYB2 | |
| PRIDE | Q9QYB2 | |
| Ensembl | ENSMUST00000069334 ENSMUST00000071533 | |
| GeneID | 13134 | |
| KEGG | mmu:13134 | |
| UCSC | uc007uur.1 uc007uus.1 | |
| CTD | 1602 | |
| MGI | MGI:1277991 | |
| eggNOG | NOG279124 | |
| GeneTree | ENSGT00390000001134 | |
| HOVERGEN | HBG065810 | |
| InParanoid | Q9QYB2 | |
| OMA | HPRMPGA | |
| OrthoDB | EOG7ZKSCN | |
| PhylomeDB | Q9QYB2 | |
| TreeFam | TF316697 | |
| ChiTaRS | Dach1 | |
| NextBio | 283192 | |
| PRO | PR:Q9QYB2 | |
| Proteomes | UP000000589 | |
| Bgee | Q9QYB2 | |
| CleanEx | MM_DACH1 | |
| ExpressionAtlas | Q9QYB2 | |
| Genevestigator | Q9QYB2 | |
| GO | GO:0005737 GO:0005634 GO:0005667 GO:0003677 GO:0001075 GO:0003700 GO:0008283 GO:0046545 GO:0060244 GO:0048147 GO:0000122 GO:0006355 GO:0007585 GO:0051123 GO:0001967 | |
| Gene3D | 3.10.260.20 | |
| InterPro | IPR009061 IPR003380 | |
| Pfam | PF02437 | |
| SUPFAM | SSF46955 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0033262 |
regulation of DNA replication involved in S phase |
ECO:0000315 |
P |
Inducible DACH1 expression inhibits colony formation and tumor growth in vivo. |
complete | |||||
| GO:0043433 |
negative regulation of sequence-specific DNA binding transcription factor activity |
ECO:0000315 |
P |
Figure 5D shows the cyclin D1 promoter was repressed in a dose-dependent manner by the expression of DACH1, and deletion of the DACH1 DS domain abrogated repression of the cyclin D1 promoter. |
complete | |||||
|
involved_in |
GO:0033262 |
regulation of nuclear cell cycle DNA replication |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1277991 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1277991 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0005677 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000279 |
negative regulation of DNA biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060244 |
negative regulation of cell proliferation involved in contact inhibition |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:96646 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048147 |
negative regulation of fibroblast proliferation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:96646 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0048147 |
negative regulation of fibroblast proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0046545 |
development of primary female sexual characteristics |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1890446 |
P |
has_participant:(EMAPA:27665) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030336 |
negative regulation of cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010944 |
negative regulation of transcription by competitive promoter binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008283 |
cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2448366 |
P |
|
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0007585 |
respiratory gaseous exchange |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2182311 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16543)|part_of:(EMAPA:16801) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000333) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:O09106 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005667 |
transcription factor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16543)|part_of:(EMAPA:16801) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0001967 |
suckling behavior |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2182311 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:96646 |
P |
has_regulation_target:(MGI:MGI:108069)|has_regulation_target:(MGI:MGI:1339656) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2448366 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000279 |
negative regulation of DNA biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UI36 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UI36 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030336 |
negative regulation of cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UI36 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010944 |
negative regulation of transcription by competitive promoter binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UI36 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001227 |
DNA-binding transcription repressor activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UI36 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UI36 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UI36 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9UI36 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Wu, K et al. (2006) DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth. Mol. Cell. Biol. 26 7116-29 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Wu, K et al. (2007) Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol. Biol. Cell 18 755-67 PubMed GONUTS page
- ↑ Davis, RJ et al. (2008) Mouse Dach1 and Dach2 are redundantly required for Müllerian duct development. Genesis 46 205-13 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Kalousova, A et al. (2010) Dachshund homologues play a conserved role in islet cell development. Dev. Biol. 348 143-52 PubMed GONUTS page
- ↑ 6.0 6.1 Davis, RJ et al. (2001) Dach1 mutant mice bear no gross abnormalities in eye, limb, and brain development and exhibit postnatal lethality. Mol. Cell. Biol. 21 1484-90 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Li, X et al. (2003) Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature 426 247-54 PubMed GONUTS page
- ↑ 8.0 8.1 Purcell, P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr. Patterns 6 110-8 PubMed GONUTS page
- ↑ 9.0 9.1 Machon, O et al. (2000) Yeast two-hybrid system identifies the ubiquitin-conjugating enzyme mUbc9 as a potential partner of mouse Dac. Mech. Dev. 97 3-12 PubMed GONUTS page
- ↑ Horner, A et al. (2002) Fibroblast growth factor signaling regulates Dach1 expression during skeletal development. Dev. Dyn. 225 35-45 PubMed GONUTS page
- ↑ Ayres, JA et al. (2001) DACH: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homologue. Genomics 77 18-26 PubMed GONUTS page
d
- GO:0046545 ! development of primary female sexual characteristics
- GO:0003700 ! DNA-binding transcription factor activity
- GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0001227 ! DNA-binding transcription repressor activity, RNA polymerase II-specific
- GO:0003677 ! DNA binding
g
m
n
- GO:0030336 ! negative regulation of cell migration
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0048147 ! negative regulation of fibroblast proliferation
- GO:0060244 ! negative regulation of cell proliferation involved in contact inhibition
- GO:2000279 ! negative regulation of DNA biosynthetic process
- GO:0005634 ! nucleus
o
r
- GO:0033262 ! regulation of nuclear cell cycle DNA replication
- GO:0006355 ! regulation of DNA-templated transcription
- GO:0007585 ! respiratory gaseous exchange by respiratory system
- GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding
- GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding
- Rodentia
