MOUSE:DACH1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Dach1 (synonyms: Dach)
Protein Name(s)	Dachshund homolog 1 Dach1
External Links
UniProt	Q9QYB2
EMBL	AF102547 AF090436 AF090437 AF129510 BC141130 AK053594 AK047409 AJ005669
CCDS	CCDS36993.1 CCDS36994.1
RefSeq	NP_001033699.1 NP_031852.1
UniGene	Mm.320593
ProteinModelPortal	Q9QYB2
SMR	Q9QYB2
BioGrid	199044
IntAct	Q9QYB2
MINT	MINT-4092795
PhosphoSite	Q9QYB2
MaxQB	Q9QYB2
PaxDb	Q9QYB2
PRIDE	Q9QYB2
Ensembl	ENSMUST00000069334 ENSMUST00000071533
GeneID	13134
KEGG	mmu:13134
UCSC	uc007uur.1 uc007uus.1
CTD	1602
MGI	MGI:1277991
eggNOG	NOG279124
GeneTree	ENSGT00390000001134
HOVERGEN	HBG065810
InParanoid	Q9QYB2
OMA	HPRMPGA
OrthoDB	EOG7ZKSCN
PhylomeDB	Q9QYB2
TreeFam	TF316697
ChiTaRS	Dach1
NextBio	283192
PRO	PR:Q9QYB2
Proteomes	UP000000589
Bgee	Q9QYB2
CleanEx	MM_DACH1
ExpressionAtlas	Q9QYB2
Genevestigator	Q9QYB2
GO	GO:0005737 GO:0005634 GO:0005667 GO:0003677 GO:0001075 GO:0003700 GO:0008283 GO:0046545 GO:0060244 GO:0048147 GO:0000122 GO:0006355 GO:0007585 GO:0051123 GO:0001967
Gene3D	3.10.260.20
InterPro	IPR009061 IPR003380
Pfam	PF02437
SUPFAM	SSF46955

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033262	regulation of DNA replication involved in S phase	PMID:16980615^[1]	ECO:0000315			P		Inducible DACH1 expression inhibits colony formation and tumor growth in vivo.	complete CACAO 6820
	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	PMID:16980615^[1]	ECO:0000315			P		Figure 5D shows the cyclin D1 promoter was repressed in a dose-dependent manner by the expression of DACH1, and deletion of the DACH1 DS domain abrogated repression of the cyclin D1 promoter.	complete CACAO 6972
involved_in	GO:0033262	regulation of nuclear cell cycle DNA replication	PMID:16980615^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1277991 PANTHER:PTN000971376	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1277991 PANTHER:PTN000971376	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0005677 MGI:MGI:1277991 PANTHER:PTN000971376	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000279	negative regulation of DNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UI36	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060244	negative regulation of cell proliferation involved in contact inhibition	PMID:17182846^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96646	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048147	negative regulation of fibroblast proliferation	PMID:17182846^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96646	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048147	negative regulation of fibroblast proliferation	PMID:17182846^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046545	development of primary female sexual characteristics	PMID:18395837^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890446	P	has_participant:(EMAPA:27665)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UI36	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030336	negative regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UI36	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010944	negative regulation of transcription by competitive promoter binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UI36	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:20869363^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448366	P	occurs_in:(EMAPA:18816) acts_on_population_of:(CL:0000169)\|occurs_in(EMAPA:18816) acts_on_population_of:(CL:0000171)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007585	respiratory gaseous exchange	PMID:11238885^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:14628042^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:14628042^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16024294^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16543)\|part_of:(EMAPA:16801)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11025202^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000333)	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:17182846^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O09106 UniProtKB:P05627 UniProtKB:P70288 UniProtKB:Q60520 UniProtKB:Q60974	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:14628042^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16024294^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16543)\|part_of:(EMAPA:16801)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12203718^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11543628^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17954) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11025202^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14628042^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001967	suckling behavior	PMID:11238885^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182311	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UI36	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:20869363^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UI36	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UI36	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17182846^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96646	P	has_regulation_target:(MGI:MGI:108069)\|has_regulation_target:(MGI:MGI:1339656)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20869363^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2448366	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17182846^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UI36	P		Seeded From UniProt	complete
involved_in	GO:2000279	negative regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UI36 ensembl:ENSP00000482245	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UI36 ensembl:ENSP00000482245	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UI36 ensembl:ENSP00000482245	P		Seeded From UniProt	complete
involved_in	GO:0010944	negative regulation of transcription by competitive promoter binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UI36 ensembl:ENSP00000482245	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UI36 ensembl:ENSP00000482245	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UI36 ensembl:ENSP00000482245	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UI36 ensembl:ENSP00000482245	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UI36 ensembl:ENSP00000482245	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Wu, K et al. (2006) DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth. Mol. Cell. Biol. 26 7116-29 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Wu, K et al. (2007) Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol. Biol. Cell 18 755-67 PubMed GONUTS page
↑ Davis, RJ et al. (2008) Mouse Dach1 and Dach2 are redundantly required for Müllerian duct development. Genesis 46 205-13 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Kalousova, A et al. (2010) Dachshund homologues play a conserved role in islet cell development. Dev. Biol. 348 143-52 PubMed GONUTS page
↑ ^6.0 ^6.1 Davis, RJ et al. (2001) Dach1 mutant mice bear no gross abnormalities in eye, limb, and brain development and exhibit postnatal lethality. Mol. Cell. Biol. 21 1484-90 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Li, X et al. (2003) Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature 426 247-54 PubMed GONUTS page
↑ ^8.0 ^8.1 Purcell, P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr. Patterns 6 110-8 PubMed GONUTS page
↑ ^9.0 ^9.1 Machon, O et al. (2000) Yeast two-hybrid system identifies the ubiquitin-conjugating enzyme mUbc9 as a potential partner of mouse Dac. Mech. Dev. 97 3-12 PubMed GONUTS page
↑ Horner, A et al. (2002) Fibroblast growth factor signaling regulates Dach1 expression during skeletal development. Dev. Dyn. 225 35-45 PubMed GONUTS page
↑ Ayres, JA et al. (2001) DACH: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homologue. Genomics 77 18-26 PubMed GONUTS page

[PMID:16980615-1] 1.0 ^1.1 ^1.2 Wu, K et al. (2006) DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth. Mol. Cell. Biol. 26 7116-29 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17182846-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Wu, K et al. (2007) Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol. Biol. Cell 18 755-67 PubMed GONUTS page

[PMID:18395837-4] Davis, RJ et al. (2008) Mouse Dach1 and Dach2 are redundantly required for Müllerian duct development. Genesis 46 205-13 PubMed GONUTS page

[PMID:20869363-5] 5.0 ^5.1 ^5.2 Kalousova, A et al. (2010) Dachshund homologues play a conserved role in islet cell development. Dev. Biol. 348 143-52 PubMed GONUTS page

[PMID:11238885-6] 6.0 ^6.1 Davis, RJ et al. (2001) Dach1 mutant mice bear no gross abnormalities in eye, limb, and brain development and exhibit postnatal lethality. Mol. Cell. Biol. 21 1484-90 PubMed GONUTS page

[PMID:14628042-7] 7.0 ^7.1 ^7.2 ^7.3 Li, X et al. (2003) Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature 426 247-54 PubMed GONUTS page

[PMID:16024294-8] 8.0 ^8.1 Purcell, P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr. Patterns 6 110-8 PubMed GONUTS page

[PMID:11025202-9] 9.0 ^9.1 Machon, O et al. (2000) Yeast two-hybrid system identifies the ubiquitin-conjugating enzyme mUbc9 as a potential partner of mouse Dac. Mech. Dev. 97 3-12 PubMed GONUTS page

[PMID:12203718-10] Horner, A et al. (2002) Fibroblast growth factor signaling regulates Dach1 expression during skeletal development. Dev. Dyn. 225 35-45 PubMed GONUTS page

[PMID:11543628-11] Ayres, JA et al. (2001) DACH: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homologue. Genomics 77 18-26 PubMed GONUTS page

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MOUSE:DACH1

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