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RAT:PYC

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Pc
Protein Name(s) Pyruvate carboxylase, mitochondrial

Pyruvic carboxylase PCB

External Links
UniProt P52873
EMBL U32314
U36585
BC085680
PIR S68252
RefSeq NP_036876.2
XP_006230753.1
XP_006230754.1
XP_006230755.1
XP_006230756.1
XP_008758309.1
UniGene Rn.11094
ProteinModelPortal P52873
SMR P52873
IntAct P52873
MINT MINT-4592965
PhosphoSite P52873
World-2DPAGE 0004:P52873
PaxDb P52873
PRIDE P52873
Ensembl ENSRNOT00000026316
GeneID 25104
KEGG rno:25104
UCSC RGD:3262
CTD 5091
RGD 3262
eggNOG COG1038
GeneTree ENSGT00550000074986
HOGENOM HOG000282801
HOVERGEN HBG008340
InParanoid P52873
KO K01958
OMA PIEAYLD
OrthoDB EOG7WT40F
PhylomeDB P52873
TreeFam TF300535
Reactome REACT_217998
REACT_218448
REACT_244933
UniPathway UPA00138
NextBio 605431
PRO PR:P52873
Proteomes UP000002494
Genevestigator P52873
GO GO:0005743
GO:0005759
GO:0005739
GO:0005524
GO:0009374
GO:0004075
GO:0031406
GO:0003677
GO:0046872
GO:0004736
GO:0006094
GO:0006629
GO:0006107
GO:0006090
Gene3D 1.10.10.60
3.20.20.70
3.30.1490.20
3.30.470.20
3.40.50.20
InterPro IPR013785
IPR011761
IPR013815
IPR013816
IPR001882
IPR011764
IPR005482
IPR000089
IPR005481
IPR003379
IPR005479
IPR009057
IPR016185
IPR000891
IPR005930
IPR011054
IPR011053
Pfam PF02785
PF00364
PF00289
PF02786
PF00682
PF02436
PIRSF PIRSF001594
SMART SM00878
SUPFAM SSF51230
SSF51246
SSF52440
TIGRFAMs TIGR01235
PROSITE PS50975
PS50979
PS00188
PS50968
PS50991

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0071073

positive regulation of phospholipid biosynthetic process

PMID:23357280[1]

ECO:0000315

P

Fig. 2. Lower levels of many individual and total phospholipids in glucose-stimulated INS-1 832/13-derived cell lines with knocked down pyruvate carboxylase.

complete
CACAO 6618

involved_in

GO:0071073

positive regulation of phospholipid biosynthetic process

PMID:23357280[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031406

carboxylic acid binding

PMID:15507531[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0009374

biotin binding

PMID:12949377[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0009374

biotin binding

PMID:12949377[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006107

oxaloacetate metabolic process

PMID:6049928[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006107

oxaloacetate metabolic process

PMID:5773282[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006107

oxaloacetate metabolic process

PMID:15507531[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006094

gluconeogenesis

PMID:6049928[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006094

gluconeogenesis

PMID:4353083[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006090

pyruvate metabolic process

PMID:6049928[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006090

pyruvate metabolic process

PMID:5773282[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006090

pyruvate metabolic process

PMID:15507531[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:6049928[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:5773282[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:5773282[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:15507531[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004736

pyruvate carboxylase activity

PMID:12949377[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004736

pyruvate carboxylase activity

PMID:6049928[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004736

pyruvate carboxylase activity

PMID:5773282[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004736

pyruvate carboxylase activity

PMID:4353083[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004736

pyruvate carboxylase activity

PMID:15507531[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006094

gluconeogenesis

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001821692
RGD:3262
SGD:S000000422
SGD:S000003030

P

Seeded From UniProt

complete

involved_in

GO:0006090

pyruvate metabolic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001821692
RGD:3262

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97520
PANTHER:PTN001821692
RGD:3262
SGD:S000000422
SGD:S000003030
UniProtKB:P11498
UniProtKB:Q5B4R8

C

Seeded From UniProt

complete

enables

GO:0004736

pyruvate carboxylase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0027580
PANTHER:PTN001821692
RGD:3262
SGD:S000000422
SGD:S000003030

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000891
InterPro:IPR013785

F

Seeded From UniProt

complete

enables

GO:0004736

pyruvate carboxylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005930

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005479
InterPro:IPR005930
InterPro:IPR011761

F

Seeded From UniProt

complete

involved_in

GO:0006090

pyruvate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005930

P

Seeded From UniProt

complete

involved_in

GO:0006094

gluconeogenesis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005930

P

Seeded From UniProt

complete

enables

GO:0009374

biotin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005930

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011761

F

Seeded From UniProt

complete

enables

GO:0004736

pyruvate carboxylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.4.1.1

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

involved_in

GO:0006094

gluconeogenesis

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0312
UniPathway:UPA00138

P

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0170

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 MacDonald, MJ et al. (2013) Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells. Arch. Biochem. Biophys. 532 23-31 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Liu, YQ et al. (2005) Enhanced rat beta-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathway. Am. J. Physiol. Endocrinol. Metab. 288 E471-8 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Rathman, SC et al. (2003) Pharmacological biotin supplementation maintains biotin status and function in rats administered dietary carbamazepine. J. Nutr. 133 2857-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Ballard, FJ & Hanson, RW (1967) Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver. Biochem. J. 104 866-71 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Kimmich, GA & Rasmussen, H (1969) Regulation of pyruvate carboxylase activity by calcium in intact rat liver mitochondria. J. Biol. Chem. 244 190-9 PubMed GONUTS page
  6. ↑ 6.0 6.1 Wimhurst, JM & Manchester, KL (1973) Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Biochem. J. 134 143-56 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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