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PMID:22859820
Citation |
Hu, Z, Hom, S, Kudze, T, Tong, XJ, Choi, S, Aramuni, G, Zhang, W and Kaplan, JM (2012) Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans. Science 337:980-4 |
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Abstract |
The synaptic adhesion molecules neurexin and neuroligin alter the development and function of synapses and are linked to autism in humans. Here, we found that Caenorhabditis elegans neurexin (NRX-1) and neuroligin (NLG-1) mediated a retrograde synaptic signal that inhibited neurotransmitter release at neuromuscular junctions. Retrograde signaling was induced in mutants lacking a muscle microRNA (miR-1) and was blocked in mutants lacking NLG-1 or NRX-1. Release was rapid and abbreviated when the retrograde signal was on, whereas release was slow and prolonged when retrograde signaling was blocked. The retrograde signal adjusted release kinetics by inhibiting exocytosis of synaptic vesicles (SVs) that are distal to the site of calcium entry. Inhibition of release was mediated by increased presynaptic levels of tomosyn, an inhibitor of SV fusion. |
Links |
PubMed Online version:10.1126/science.1224896 |
Keywords |
Acetylcholine/metabolism; Animals; Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Cell Adhesion Molecules, Neuronal/genetics; Cell Adhesion Molecules, Neuronal/metabolism; Cholinergic Neurons/physiology; Excitatory Postsynaptic Potentials; Exocytosis; Kinetics; Mice; MicroRNAs/genetics; MicroRNAs/metabolism; Motor Neurons/physiology; Mutation; Neural Inhibition; Neuromuscular Junction/physiology; Neurotransmitter Agents/metabolism; Synaptic Transmission; Synaptic Vesicles/physiology; Transcription Factors/genetics; Transcription Factors/metabolism; Transfection |
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Significance
Annotations
Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|
GO:0046929: negative regulation of neurotransmitter secretion |
ECO:0000315: |
P |
See figure 1. |
complete | ||||
involved_in |
GO:0046929: negative regulation of neurotransmitter secretion |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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