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PMID:22859820

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Citation

Hu, Z, Hom, S, Kudze, T, Tong, XJ, Choi, S, Aramuni, G, Zhang, W and Kaplan, JM (2012) Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans. Science 337:980-4

Abstract

The synaptic adhesion molecules neurexin and neuroligin alter the development and function of synapses and are linked to autism in humans. Here, we found that Caenorhabditis elegans neurexin (NRX-1) and neuroligin (NLG-1) mediated a retrograde synaptic signal that inhibited neurotransmitter release at neuromuscular junctions. Retrograde signaling was induced in mutants lacking a muscle microRNA (miR-1) and was blocked in mutants lacking NLG-1 or NRX-1. Release was rapid and abbreviated when the retrograde signal was on, whereas release was slow and prolonged when retrograde signaling was blocked. The retrograde signal adjusted release kinetics by inhibiting exocytosis of synaptic vesicles (SVs) that are distal to the site of calcium entry. Inhibition of release was mediated by increased presynaptic levels of tomosyn, an inhibitor of SV fusion.

Links

PubMed Online version:10.1126/science.1224896

Keywords

Acetylcholine/metabolism; Animals; Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Cell Adhesion Molecules, Neuronal/genetics; Cell Adhesion Molecules, Neuronal/metabolism; Cholinergic Neurons/physiology; Excitatory Postsynaptic Potentials; Exocytosis; Kinetics; Mice; MicroRNAs/genetics; MicroRNAs/metabolism; Motor Neurons/physiology; Mutation; Neural Inhibition; Neuromuscular Junction/physiology; Neurotransmitter Agents/metabolism; Synaptic Transmission; Synaptic Vesicles/physiology; Transcription Factors/genetics; Transcription Factors/metabolism; Transfection

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:NLGN1

GO:0046929: negative regulation of neurotransmitter secretion

ECO:0000315:

P

See figure 1.

complete
CACAO 7164

CAEEL:NLGN1

involved_in

GO:0046929: negative regulation of neurotransmitter secretion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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