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It is now the 6th OPEN Period for CACAO Spring 2018! It will end on Monday April 23, 2018 at 05:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

It is now the 4th OPEN Period for CACAO Phage Hunters 2018! It will end on Sunday April 22, 2018 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

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CAEEL:NLGN1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) nlg-1
Protein Name(s) Neuroligin-1
External Links
UniProt Q9XTG1
EMBL Z70266
AL023827
Z70266
AL023827
PIR T19864
RefSeq NP_510283.1
NP_872254.1
UniGene Cel.5537
ProteinModelPortal Q9XTG1
SMR Q9XTG1
BioGrid 46385
DIP DIP-26014N
MINT MINT-1043580
STRING 6239.C40C9.5c
PaxDb Q9XTG1
PRIDE Q9XTG1
EnsemblMetazoa C40C9.5a
GeneID 181484
KEGG cel:CELE_C40C9.5
UCSC C40C9.5a
CTD 181484
WormBase C40C9.5a
C40C9.5b
eggNOG COG2272
GeneTree ENSGT00760000118946
HOGENOM HOG000018382
InParanoid Q9XTG1
PhylomeDB Q9XTG1
NextBio 914136
PRO PR:Q9XTG1
Proteomes UP000001940
ExpressionAtlas Q9XTG1
GO GO:0030424
GO:0009986
GO:0030425
GO:0005887
GO:0005886
GO:0045202
GO:0042043
GO:0004872
GO:0007155
GO:0007416
Gene3D 3.40.50.1820
InterPro IPR029058
IPR002018
Pfam PF00135
SUPFAM SSF53474

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0046929

negative regulation of neurotransmitter secretion

PMID:22859820[1]

IMP: Inferred from Mutant Phenotype

P

See figure 1.

complete
CACAO 7164

GO:0004872

receptor activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000168538

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:21611156[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000168538

C

Seeded From UniProt

complete

GO:0007155

cell adhesion

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

GO:0007158

neuron cell-cell adhesion

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000168538

P

Seeded From UniProt

complete

GO:0009986

cell surface

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000168538

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0030424

axon

PMID:18255029[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030425

dendrite

PMID:18255029[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0042043

neurexin family protein binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000168538

F

Seeded From UniProt

complete

GO:0045202

synapse

PMID:18255029[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0045202

synapse

PMID:20083577[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0046929

negative regulation of neurotransmitter secretion

PMID:22859820[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048488

synaptic vesicle endocytosis

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000168538

P

Seeded From UniProt

complete

GO:0050804

modulation of synaptic transmission

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000168538

P

Seeded From UniProt

complete

GO:0097104

postsynaptic membrane assembly

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000168538

P

Seeded From UniProt

complete

GO:0097105

presynaptic membrane assembly

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000168538

P

Seeded From UniProt

complete

NOT

GO:0004104

cholinesterase activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000168538

F

Seeded From UniProt

complete

NOT

GO:0005615

extracellular space

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000168538

C

Seeded From UniProt

complete

NOT

GO:0006581

acetylcholine catabolic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000168538

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Hu, Z et al. (2012) Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans. Science 337 980-4 PubMed GONUTS page
  2. Meissner, B et al. (2011) Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. PLoS ONE 6 e19937 PubMed GONUTS page
  3. 3.0 3.1 3.2 Feinberg, EH et al. (2008) GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems. Neuron 57 353-63 PubMed GONUTS page
  4. Hunter, JW et al. () Neuroligin-deficient mutants of C. elegans have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicity. Dis Model Mech 3 366-76 PubMed GONUTS page