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CAEEL:NLGN1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) nlg-1
Protein Name(s) Neuroligin-1
External Links
UniProt Q9XTG1
EMBL Z70266
AL023827
Z70266
AL023827
PIR T19864
RefSeq NP_510283.1
NP_872254.1
UniGene Cel.5537
ProteinModelPortal Q9XTG1
SMR Q9XTG1
BioGrid 46385
DIP DIP-26014N
MINT MINT-1043580
STRING 6239.C40C9.5c
PaxDb Q9XTG1
PRIDE Q9XTG1
EnsemblMetazoa C40C9.5a
GeneID 181484
KEGG cel:CELE_C40C9.5
UCSC C40C9.5a
CTD 181484
WormBase C40C9.5a
C40C9.5b
eggNOG COG2272
GeneTree ENSGT00760000118946
HOGENOM HOG000018382
InParanoid Q9XTG1
PhylomeDB Q9XTG1
NextBio 914136
PRO PR:Q9XTG1
Proteomes UP000001940
ExpressionAtlas Q9XTG1
GO GO:0030424
GO:0009986
GO:0030425
GO:0005887
GO:0005886
GO:0045202
GO:0042043
GO:0004872
GO:0007155
GO:0007416
Gene3D 3.40.50.1820
InterPro IPR029058
IPR002018
Pfam PF00135
SUPFAM SSF53474

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0046929

negative regulation of neurotransmitter secretion

PMID:22859820[1]

ECO:0000315

P

See figure 1.

complete
CACAO 7164

involved_in

GO:0046929

negative regulation of neurotransmitter secretion

PMID:22859820[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:20083577[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:18255029[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

PMID:18255029[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:18255029[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21611156[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(WBbt:0006804)

Seeded From UniProt

complete

involved_in

GO:0048488

synaptic vesicle endocytosis

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0083963
PANTHER:PTN000168538

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
MGI:MGI:2681835
MGI:MGI:3775191
PANTHER:PTN000168538
RGD:621117
RGD:621119
WB:WBGene00006412

C

Seeded From UniProt

complete

enables

GO:0042043

neurexin family protein binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0031866
MGI:MGI:2179435
MGI:MGI:2681835
PANTHER:PTN000168538
RGD:621117
RGD:621119
UniProtKB:Q8N0W4

F

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000168538
RGD:621117
RGD:621119

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
PANTHER:PTN000168538
RGD:621117
RGD:621118
RGD:621119
UniProtKB:Q8N0W4
UniProtKB:Q9NZ94

C

Seeded From UniProt

complete

involved_in

GO:0007158

neuron cell-cell adhesion

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
PANTHER:PTN000168538
RGD:621117
RGD:621118
RGD:621119

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
PANTHER:PTN000168538
UniProtKB:Q8N0W4

C

Seeded From UniProt

complete

involved_in

GO:0097105

presynaptic membrane assembly

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
MGI:MGI:2681835
PANTHER:PTN000168538
RGD:621117
RGD:621118
RGD:621119
UniProtKB:Q8N0W4

P

Seeded From UniProt

complete

involved_in

GO:0097104

postsynaptic membrane assembly

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
MGI:MGI:2444609
MGI:MGI:2681835
PANTHER:PTN000168538

P

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
MGI:MGI:2444609
MGI:MGI:2681835
PANTHER:PTN000168538
RGD:621117

P

Seeded From UniProt

complete

part_of

GO:0098793

presynapse

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048488

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770
UniProtKB-SubCell:SL-0258

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Hu, Z et al. (2012) Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans. Science 337 980-4 PubMed GONUTS page
  2. Hunter, JW et al. () Neuroligin-deficient mutants of C. elegans have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicity. Dis Model Mech 3 366-76 PubMed GONUTS page
  3. 3.0 3.1 3.2 Feinberg, EH et al. (2008) GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems. Neuron 57 353-63 PubMed GONUTS page
  4. Meissner, B et al. (2011) Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. PLoS ONE 6 e19937 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page