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HUMAN:TOIP2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TOR1AIP2 (synonyms: IFRG15, LULL1) | |
| Protein Name(s) | Torsin-1A-interacting protein 2
Lumenal domain-like LAP1 | |
| External Links | ||
| UniProt | Q8NFQ8 | |
| EMBL | AF464140 AL359853 BC101532 BC112225 | |
| CCDS | CCDS1334.1 | |
| RefSeq | NP_001186189.1 NP_659471.1 XP_005244996.1 | |
| UniGene | Hs.571797 Hs.723247 | |
| ProteinModelPortal | Q8NFQ8 | |
| SMR | Q8NFQ8 | |
| BioGrid | 127870 | |
| IntAct | Q8NFQ8 | |
| STRING | 9606.ENSP00000356584 | |
| PhosphoSite | Q8NFQ8 | |
| DMDM | 74751288 | |
| MaxQB | Q8NFQ8 | |
| PaxDb | Q8NFQ8 | |
| PeptideAtlas | Q8NFQ8 | |
| PRIDE | Q8NFQ8 | |
| DNASU | 163590 | |
| Ensembl | ENST00000367612 ENST00000609928 | |
| GeneID | 163590 | |
| KEGG | hsa:163590 | |
| UCSC | uc001gnk.3 | |
| CTD | 163590 | |
| GeneCards | GC01M179809 | |
| HGNC | HGNC:24055 | |
| HPA | HPA051849 | |
| MIM | 614513 | |
| neXtProt | NX_Q8NFQ8 | |
| PharmGKB | PA142670716 | |
| eggNOG | NOG40503 | |
| GeneTree | ENSGT00390000012166 | |
| HOGENOM | HOG000154661 | |
| HOVERGEN | HBG094081 | |
| InParanoid | Q8NFQ8 | |
| OMA | HHVADAY | |
| OrthoDB | EOG7G7KQH | |
| PhylomeDB | Q8NFQ8 | |
| TreeFam | TF329438 | |
| ChiTaRS | TOR1AIP2 | |
| GenomeRNAi | 163590 | |
| NextBio | 88372 | |
| PRO | PR:Q8NFQ8 | |
| Proteomes | UP000005640 | |
| Bgee | Q8NFQ8 | |
| CleanEx | HS_TOR1AIP2 | |
| ExpressionAtlas | Q8NFQ8 | |
| Genevestigator | Q8NFQ8 | |
| GO | GO:0005783 GO:0005789 GO:0016021 GO:0031965 GO:0001671 GO:0051117 GO:0007029 GO:0032781 | |
| InterPro | IPR008662 | |
| Pfam | PF05609 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0090435 |
protein localization to nuclear envelope |
ECO:0000314 |
P |
Figure 1: LULL1 promotes relocalization of TorA to the NE They studied the subcellular localization of TorA with mGFP fused to its C-terminus in transfected U2OS cells |
complete | |||||
|
involved_in |
GO:0090435 |
protein localization to nuclear envelope |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051117 |
ATPase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051117 |
ATPase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032781 |
positive regulation of ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032781 |
positive regulation of ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007029 |
endoplasmic reticulum organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001671 |
ATPase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001671 |
ATPase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BYU6 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Vander Heyden, AB et al. (2009) LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation. Mol. Biol. Cell 20 2661-72 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Rose, AE et al. (2014) Arresting a Torsin ATPase reshapes the endoplasmic reticulum. J. Biol. Chem. 289 552-64 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Zhao, C et al. (2013) Regulation of Torsin ATPases by LAP1 and LULL1. Proc. Natl. Acad. Sci. U.S.A. 110 E1545-54 PubMed GONUTS page
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