HUMAN:NLGN1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NLGN1 (synonyms: KIAA1070)
Protein Name(s)	Neuroligin-1
External Links
UniProt	Q8N2Q7
EMBL	AB028993 AC008082 AC008120 AC092923 AC092967 AC110871 AC131158 BC032555 AK074522
CCDS	CCDS3222.1
RefSeq	NP_055747.1 XP_005247291.1 XP_005247292.1
UniGene	Hs.478289 Hs.732502
ProteinModelPortal	Q8N2Q7
SMR	Q8N2Q7
BioGrid	116538
IntAct	Q8N2Q7
MINT	MINT-1901478
STRING	9606.ENSP00000354541
MEROPS	S09.994
PhosphoSite	Q8N2Q7
DMDM	31076822
PaxDb	Q8N2Q7
PRIDE	Q8N2Q7
DNASU	22871
Ensembl	ENST00000361589 ENST00000457714
GeneID	22871
KEGG	hsa:22871
UCSC	uc003fio.1
CTD	22871
GeneCards	GC03P173114
HGNC	HGNC:14291
HPA	HPA006680
MIM	600568
neXtProt	NX_Q8N2Q7
PharmGKB	PA31647
eggNOG	COG2272
GeneTree	ENSGT00760000118946
HOGENOM	HOG000231424
HOVERGEN	HBG008839
InParanoid	Q8N2Q7
KO	K07378
OrthoDB	EOG7RBZ7R
PhylomeDB	Q8N2Q7
TreeFam	TF326187
ChiTaRS	NLGN1
GeneWiki	NLGN1
GenomeRNAi	22871
NextBio	43403
PRO	PR:Q8N2Q7
Proteomes	UP000005640
Bgee	Q8N2Q7
CleanEx	HS_NLGN1
ExpressionAtlas	Q8N2Q7
Genevestigator	Q8N2Q7
GO	GO:0030054 GO:0009986 GO:0030425 GO:0009897 GO:0032433 GO:0005887 GO:0017146 GO:0097481 GO:0045211 GO:0045202 GO:0050839 GO:0042043 GO:0030165 GO:0046983 GO:0004872 GO:0097113 GO:0016339 GO:0048789 GO:0045184 GO:0007157 GO:0097114 GO:0007399 GO:0097115 GO:0007158 GO:0023041 GO:0060999 GO:2000463 GO:0051491 GO:1902533 GO:1900029 GO:0051965 GO:0032230 GO:0051968 GO:1900244 GO:2000302 GO:0097119 GO:0097104 GO:0097105 GO:0051290 GO:0051260 GO:0035418 GO:0006605 GO:0097120 GO:2000311 GO:2000310 GO:0045664 GO:0002087 GO:0007416 GO:0097091 GO:0016080 GO:0072553
Gene3D	3.40.50.1820
InterPro	IPR029058 IPR002018 IPR019819 IPR000460 IPR030022
PANTHER	PTHR11559:SF52
Pfam	PF00135
PRINTS	PR01090
SUPFAM	SSF53474
PROSITE	PS00941

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0031175	neuron projection development	PMID:22750515^[1]	ECO:0000314			P		"The ability of NLGN1 to induce neurite outgrowth was evaluated by incubating the neurons with increasing concentrations of recombinant NLGN1." (Page 4177) This was followed by fluorescence staining.	complete CACAO 7162
involved_in	GO:0140058	neuron projection arborization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	F	part_of:(GO:0071277)	Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P	regulates_o_occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P	regulates_o_occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	PMID:25428619^[2]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:25428619^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:14522992^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	occurs_in:(GO:0045202) occurs_in:(GO:0005615)	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:14522992^[3]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:14522992^[3]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P	transports_or_maintains_localization_of:(UniProtKB:Q9BT88)	Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:17474715^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C	part_of:(CL:0002608)	Seeded From UniProt	complete
colocalizes_with	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C	part_of:(GO:0030425) part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C	part_of:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P	occurs_in:(GO:0048786) occurs_in:(CL:0000540) occurs_in:(GO:0030425)	Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:23143522^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99K10	P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:23143522^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99K10	P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	PMID:23143522^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99K10	P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	PMID:23143522^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99K10	P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:22750515^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:17474715^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P78352)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:26440732^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	C		Seeded From UniProt	complete
involved_in	GO:1904861	excitatory synapse assembly	PMID:26440732^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P	results_in_development_of:(GO:0098978)	Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:2000302	positive regulation of synaptic vesicle exocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:1902533	positive regulation of intracellular signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:1900029	positive regulation of ruffle assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0097115	neurexin clustering involved in presynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0072553	terminal button organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	F		Seeded From UniProt	complete
involved_in	GO:0048789	cytoskeletal matrix organization at active zone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0048789	cytoskeletal matrix organization at active zone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	F		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	F		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
part_of	GO:0032433	filopodium tip	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C		Seeded From UniProt	complete
involved_in	GO:0032230	positive regulation of synaptic transmission, GABAergic	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:21838267^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	F		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
involved_in	GO:0016080	synaptic vesicle targeting	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0006605	protein targeting	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62765	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	C		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119 UniProtKB:Q8N0W4	P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2444609 MGI:MGI:2681835 PANTHER:PTN000168538	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2444609 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0083963 PANTHER:PTN000168538	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2681835 MGI:MGI:3775191 PANTHER:PTN000168538 RGD:621117 RGD:621119 WB:WBGene00006412	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0031866 MGI:MGI:2179435 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117 RGD:621119 UniProtKB:Q8N0W4	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000168538 RGD:621117 RGD:621119	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119 UniProtKB:Q8N0W4 UniProtKB:Q9NZ94	C		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 UniProtKB:Q8N0W4	C		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	PMID:24613359^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016080	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016080	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048488	C		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:2000302	positive regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:1905520	positive regulation of presynaptic active zone assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:1902533	positive regulation of intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:1902474	positive regulation of protein localization to synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:1900029	positive regulation of ruffle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0140058	neuron projection arborization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0099174	regulation of presynapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
involved_in	GO:0098942	retrograde trans-synaptic signaling by trans-synaptic protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0072553	terminal button organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	F		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0048789	cytoskeletal matrix organization at active zone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	F		Seeded From UniProt	complete
part_of	GO:0032433	filopodium tip	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
involved_in	GO:0032230	positive regulation of synaptic transmission, GABAergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
involved_in	GO:0006605	protein targeting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62765 ensembl:ENSRNOP00000075793	C		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	F		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0016080	synaptic vesicle targeting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	C		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	C		Seeded From UniProt	complete
involved_in	GO:0002087	regulation of respiratory gaseous exchange by neurological system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:2000809	positive regulation of synaptic vesicle clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:2000302	positive regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:1904861	excitatory synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0099560	synaptic membrane adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	C		Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097115	neurexin clustering involved in presynaptic membrane assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0072553	terminal button organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0048789	cytoskeletal matrix organization at active zone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000460	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000460 InterPro:IPR030022	F		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	C		Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:15797875^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:15797875^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0023041	neuronal signal transduction	PMID:15797875^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:15797875^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0099054	presynapse assembly	PMID:21838267^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0098985	asymmetric, glutamatergic, excitatory synapse	PMID:21838267^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0089717	spanning component of membrane	PMID:21838267^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-6797568 Reactome:R-HSA-6797554 Reactome:R-HSA-6794346	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Gjørlund, MD et al. (2012) Neuroligin-1 induces neurite outgrowth through interaction with neurexin-1β and activation of fibroblast growth factor receptor-1. FASEB J. 26 4174-86 PubMed GONUTS page
↑ ^2.0 ^2.1 Fang, M et al. (2016) Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability. Mol. Neurobiol. 53 270-284 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Comoletti, D et al. (2003) Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. J. Biol. Chem. 278 50497-505 PubMed GONUTS page
↑ ^4.0 ^4.1 Saro, D et al. (2007) A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95. Biochemistry 46 6340-52 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Kwon, HB et al. (2012) Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number. Nat. Neurosci. 15 1667-74 PubMed GONUTS page
↑ ^6.0 ^6.1 Tristán-Clavijo, E et al. (2015) A truncating mutation in Alzheimer's disease inactivates neuroligin-1 synaptic function. Neurobiol. Aging 36 3171-3175 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Dinamarca, MC et al. (2011) The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease? Biochemistry 50 8127-37 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Chubykin, AA et al. (2005) Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J. Biol. Chem. 280 22365-74 PubMed GONUTS page

[PMID:22750515-1] 1.0 ^1.1 Gjørlund, MD et al. (2012) Neuroligin-1 induces neurite outgrowth through interaction with neurexin-1β and activation of fibroblast growth factor receptor-1. FASEB J. 26 4174-86 PubMed GONUTS page

[PMID:25428619-2] 2.0 ^2.1 Fang, M et al. (2016) Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability. Mol. Neurobiol. 53 270-284 PubMed GONUTS page

[PMID:14522992-3] 3.0 ^3.1 ^3.2 Comoletti, D et al. (2003) Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. J. Biol. Chem. 278 50497-505 PubMed GONUTS page

[PMID:17474715-4] 4.0 ^4.1 Saro, D et al. (2007) A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95. Biochemistry 46 6340-52 PubMed GONUTS page

[PMID:23143522-5] 5.0 ^5.1 ^5.2 ^5.3 Kwon, HB et al. (2012) Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number. Nat. Neurosci. 15 1667-74 PubMed GONUTS page

[PMID:26440732-6] 6.0 ^6.1 Tristán-Clavijo, E et al. (2015) A truncating mutation in Alzheimer's disease inactivates neuroligin-1 synaptic function. Neurobiol. Aging 36 3171-3175 PubMed GONUTS page

[PMID:21838267-7] 7.0 ^7.1 ^7.2 ^7.3 Dinamarca, MC et al. (2011) The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease? Biochemistry 50 8127-37 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24613359-9] Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page

[PMID:15797875-10] 10.0 ^10.1 ^10.2 ^10.3 Chubykin, AA et al. (2005) Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J. Biol. Chem. 280 22365-74 PubMed GONUTS page

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