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DROME:Q9NGK5

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided.
Protein Name(s) FI21425p1 (ECO:0000313 with EMBL:AGV77151.1)

Neuroligin (ECO:0000313 with EMBL:AAF68455.1) Neuroligin 2, isoform A (ECO:0000313 with EMBL:AAF52450.2) Neuroligin 2, isoform B (ECO:0000313 with EMBL:AFH03590.1) Neuroligin 2, isoform C (ECO:0000313 with EMBL:AHN54208.1)

External Links
UniProt Q9NGK5
EMBL AE014134
AF251479
AE014134
BT150249
AE014134
RefSeq NP_001245916.1
NP_523496.1
UniGene Dm.2735
SMR Q9NGK5
STRING 7227.FBpp0078972
MEROPS S09.986
EnsemblMetazoa FBtr0079344
FBtr0307033
GeneID 33962
KEGG dme:Dmel_CG13772
UCSC CG13772-RA
CTD 33962
FlyBase FBgn0031866
GeneTree ENSGT00760000118946
OMA HFNINDQ
PhylomeDB Q9NGK5
GenomeRNAi 33962
NextBio 786159
Proteomes UP000000803
GO GO:0009986
GO:0005887
GO:0045211
GO:0045202
GO:0052689
GO:0042043
GO:0004872
GO:0007628
GO:0002121
GO:0048790
GO:0048065
GO:0045433
GO:0007274
GO:2000331
GO:0035176
GO:0007416
GO:0060074
GO:0050808
GO:0051124
GO:0048499
Gene3D 3.40.50.1820
InterPro IPR029058
IPR002018
IPR019819
Pfam PF00135
SUPFAM SSF53474
PROSITE PS00941

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0031594

neuromuscular junction

PMID:21228178[1]

ECO:0000314

C

Figure 1: Increased concentration of protein at the NMJs.

complete
CACAO 7156

GO:0050805

positive regulation of synaptic transmission

PMID:21228178[1]

ECO:0000315

P

Inferred from electrophysiology experiments. See figure 3.

complete
CACAO 7157

GO:0008345

larval locomotory behavior

PMID:21228178[1]

ECO:0000315

P

Fig Supplementary 3 (or Fig 9).

complete
CACAO 7159

involved_in

GO:0008345

larval locomotory behavior

PMID:21228178[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050805

negative regulation of synaptic transmission

PMID:21228178[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031594

neuromuscular junction

PMID:21228178[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:2000331

regulation of terminal button organization

PMID:22426000[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048790

maintenance of presynaptic active zone structure

PMID:22426000[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048499

synaptic vesicle membrane organization

PMID:22426000[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0045211

postsynaptic membrane

PMID:22426000[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0097105

presynaptic membrane assembly

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
MGI:MGI:2681835
PANTHER:PTN000168538
RGD:621117
RGD:621118
RGD:621119
UniProtKB:Q8N0W4

P

Seeded From UniProt

complete

involved_in

GO:0097104

postsynaptic membrane assembly

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
MGI:MGI:2444609
MGI:MGI:2681835
PANTHER:PTN000168538

P

Seeded From UniProt

complete

involved_in

GO:0050804

modulation of chemical synaptic transmission

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
MGI:MGI:2444609
MGI:MGI:2681835
PANTHER:PTN000168538
RGD:621117

P

Seeded From UniProt

complete

involved_in

GO:0048488

synaptic vesicle endocytosis

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0083963
PANTHER:PTN000168538

P

Seeded From UniProt

complete

part_of

GO:0045202

synapse

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
MGI:MGI:2681835
MGI:MGI:3775191
PANTHER:PTN000168538
RGD:621117
RGD:621119
WB:WBGene00006412

C

Seeded From UniProt

complete

enables

GO:0042043

neurexin family protein binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0031866
MGI:MGI:2179435
MGI:MGI:2681835
PANTHER:PTN000168538
RGD:621117
RGD:621119
UniProtKB:Q8N0W4

F

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000168538
RGD:621117
RGD:621119

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
PANTHER:PTN000168538
RGD:621117
RGD:621118
RGD:621119
UniProtKB:Q8N0W4
UniProtKB:Q9NZ94

C

Seeded From UniProt

complete

involved_in

GO:0007158

neuron cell-cell adhesion

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
PANTHER:PTN000168538
RGD:621117
RGD:621118
RGD:621119

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2179435
PANTHER:PTN000168538
UniProtKB:Q8N0W4

C

Seeded From UniProt

complete

involved_in

GO:0045433

male courtship behavior, veined wing generated song production

PMID:23792025[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007628

adult walking behavior

PMID:23792025[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035176

social behavior

PMID:23792025[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002121

inter-male aggressive behavior

PMID:23792025[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048065

male courtship behavior, veined wing extension

PMID:23792025[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007274

neuromuscular synaptic transmission

PMID:23136438[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042043

neurexin family protein binding

PMID:23136438[5]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0038975

F

Seeded From UniProt

complete

involved_in

GO:0051124

synaptic growth at neuromuscular junction

PMID:23136438[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050808

synapse organization

PMID:21228178[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060074

synapse maturation

PMID:21228178[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0098793

presynapse

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048488

C

Seeded From UniProt

complete

enables

GO:0052689

carboxylic ester hydrolase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.1.1

F

Seeded From UniProt

complete

enables

GO:0080030

methyl indole-3-acetate esterase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.1.1

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Sun, M et al. (2011) Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. J. Neurosci. 31 687-99 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Mosca, TJ et al. (2012) Trans-synaptic Teneurin signalling in neuromuscular synapse organization and target choice. Nature 484 237-41 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Hahn, N et al. (2013) Monogenic heritable autism gene neuroligin impacts Drosophila social behaviour. Behav. Brain Res. 252 450-7 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Chen, YC et al. (2012) Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission. J. Neurosci. 32 16018-30 PubMed GONUTS page
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