GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

User:Portisja

From GONUTS
Jump to: navigation, search

SUPER BOWL (Round 5)

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
acceptableENTHI:Q9U7F62012-04-15 11:17:34 CDTGO:0032509 endosome transport via multivesicular body sorting pathway (P)PMID:22500103ECO:0000314 direct assay evidence used in manual assertion

Figure 6 shows antibody tagged EhADH112 localizing along the MVB membrane after the introduction of RBC

challenge
acceptableMOUSE:GLI12012-04-15 12:25:22 CDTGO:0045667 regulation of osteoblast differentiation (P)PMID:22493482ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 shows how osteoblast differentiation is altered by defects in Gli1.

challenge
acceptableMOUSE:KLF42012-04-15 12:42:59 CDTGO:0030336 negative regulation of cell migration (P)PMID:22491752ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4 shows that knock-out of the KLF4 gene results in increased cell migration.

challenge
requireschangesHUMAN:Q9BXH22012-04-15 13:18:37 CDTGO:0045605 negative regulation of epidermal cell differentiation (P)PMID:22417306ECO:0000314 direct assay evidence used in manual assertion

Figure 4 shows that knock-down of STAT3 expression triggers cell differentiation.

challenge
acceptableMOUSE:ETS12012-04-15 13:37:41 CDTGO:0050728 negative regulation of inflammatory response (P)PMID:22294049ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4 shows that mutants of the ETS1 gene have increased protein levels of the proteins secreted during inflammatory response.

challenge
acceptableMOUSE:ATF32012-04-15 14:07:57 CDTGO:0070373 negative regulation of ERK1 and ERK2 cascade (P)PMID:22053207ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4 shows the relative protein levels of proteins produced in the ERK cascade after the ATF3 gene has been knocked out as compared to the wild type gene expression.

challenge
requireschangesAGGAC:D4EB472012-04-15 14:50:39 CDTGO:1900192 positive regulation of single-species biofilm formation (Figure 1 shows a large decrease in biofilm area and depth after the expression of QseC is repressed.)PMID:20404080IMP: Inferred from Mutant Phenotype
challenge
requireschangesSALTY:E7UUT82012-04-15 15:08:23 CDTGO:2000154 negative regulation of flagellar cell motility (Figure 2 shows relative motility levels of the WT and a QseC mutant.)PMID:20227482IMP: Inferred from Mutant Phenotype
challenge
requireschangesEDWTA:E3UKS82012-04-15 15:17:22 CDTGO:2000154 negative regulation of flagellar cell motility (P)PMID:21288493ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 shows a motility assay for the WT and QseBC deletion mutants.

challenge
acceptableEDWTA:E3UKS82012-04-15 15:17:22 CDTGO:0009405 pathogenesis (P)PMID:21288493ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4 shows a survival curve for WT and deletion mutants.

challenge

acceptable:6
unacceptable:0
requires_changes:4
flagged:0

Annotations challenged by Portisja

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history
requireschangesBeebeje1,
Team Gene Queens
STAAU:ARSCGO:0055114 - obsolete oxidation-reduction process (P)PMID:1409657ECO:0000316 genetic interaction evidence used in manual assertionchallengeC: 1
acceptableChrispond,
Team Big Mama 50000
ECOLI:PUTAGO:0004657 - proline dehydrogenase activity (F)PMID:22040654ECO:0000314 direct assay evidence used in manual assertionchallengeC: 1
acceptableEwillis,
Team Bazinga
HUMAN:CDC5LGO:0005737 - cytoplasm (C)PMID:9038199ECO:0000314 direct assay evidence used in manual assertionchallengeC: 1

0 annotations fixed by Portisja


MSU Internal

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks

acceptable:0
unacceptable:0
requires_changes:0
flagged:0

Annotations challenged by Portisja

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history
requireschangesBeebeje1,
Team Gene Queens
STAAU:ARSCGO:0055114 - obsolete oxidation-reduction process (P)PMID:1409657ECO:0000316 genetic interaction evidence used in manual assertionchallengeC: 1

0 annotations fixed by Portisja