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MOUSE:ETS1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ets1 (synonyms: Ets-1)
Protein Name(s) Protein C-ets-1

p54

External Links
UniProt P27577
EMBL M58482
X53953
X55787
BC010588
CCDS CCDS22954.1
PIR A30487
I48291
RefSeq NP_035938.2
UniGene Mm.292415
PDB 1K78
1K79
1K7A
1MD0
1MDM
1R36
2JV3
2KMD
PDBsum 1K78
1K79
1K7A
1MD0
1MDM
1R36
2JV3
2KMD
DisProt DP00111
ProteinModelPortal P27577
SMR P27577
BioGrid 204765
DIP DIP-41848N
IntAct P27577
MINT MINT-194860
STRING 10090.ENSMUSP00000034534
PhosphoSite P27577
MaxQB P27577
PRIDE P27577
Ensembl ENSMUST00000034534
GeneID 23871
KEGG mmu:23871
UCSC uc009osb.1
CTD 2113
MGI MGI:95455
eggNOG NOG305402
HOGENOM HOG000285953
HOVERGEN HBG003088
InParanoid P27577
KO K02678
OMA DEMATQE
OrthoDB EOG77127T
PhylomeDB P27577
TreeFam TF316214
Reactome REACT_188971
ChiTaRS Ets1
EvolutionaryTrace P27577
NextBio 303577
PRO PR:P27577
Proteomes UP000000589
Bgee P27577
CleanEx MM_ETS1
ExpressionAtlas P27577
Genevestigator P27577
GO GO:0005737
GO:0045171
GO:0005634
GO:0005667
GO:0003677
GO:0043565
GO:0000981
GO:0003700
GO:0060055
GO:0030154
GO:0048870
GO:0070301
GO:0007565
GO:0021854
GO:0002376
GO:0045786
GO:0021983
GO:0030578
GO:0045766
GO:0008284
GO:0010595
GO:0045648
GO:0045944
GO:0045893
GO:0045765
GO:0042981
GO:0010715
GO:0006357
GO:0046677
GO:0032355
GO:0001666
GO:0070555
GO:0034616
GO:0009612
GO:0006366
Gene3D 1.10.10.10
1.10.150.50
InterPro IPR000418
IPR003118
IPR013761
IPR016311
IPR011991
Pfam PF00178
PF02198
PIRSF PIRSF001698
PRINTS PR00454
SMART SM00413
SM00251
SUPFAM SSF47769
PROSITE PS00345
PS00346
PS50061
PS51433

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0050728

negative regulation of inflammatory response

PMID:22294049[1]

ECO:0000315

P

Figure 4 shows that mutants of the ETS1 gene have increased protein levels of the proteins secreted during inflammatory response.

complete
CACAO 4887

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:12119294[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:53313)

Seeded From UniProt

complete

enables

GO:1990837

sequence-specific double-stranded DNA binding

PMID:15994560[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050728

negative regulation of inflammatory response

PMID:22294049[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P14921-1

P

Seeded From UniProt

complete

involved_in

GO:0045765

regulation of angiogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

involved_in

GO:0045648

positive regulation of erythrocyte differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

involved_in

GO:0010595

positive regulation of endothelial cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P14921-1

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P14921-1

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:7774816[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109336
PANTHER:PTN000218930

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95455
MGI:MGI:95610
MGI:MGI:98282
PANTHER:PTN000218930
UniProtKB:Q15723

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000097
FB:FBgn0000567
FB:FBgn0003118
MGI:MGI:101762
MGI:MGI:107180
MGI:MGI:109637
MGI:MGI:1335079
MGI:MGI:1353422
MGI:MGI:2449712
MGI:MGI:95455
MGI:MGI:95554
MGI:MGI:95610
MGI:MGI:98282
MGI:MGI:99423
PANTHER:PTN000218930
RGD:1359607
RGD:1598663
RGD:2583
UniProtKB:P14921
UniProtKB:P17947
UniProtKB:P19419
UniProtKB:P32519
UniProtKB:P41161
UniProtKB:Q01543
UniProtKB:Q06546
WB:WBGene00002990
WB:WBGene00017687

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218930
UniProtKB:Q15723

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904996

positive regulation of leukocyte adhesion to vascular endothelial cell

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061614

pri-miRNA transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051272

positive regulation of cellular component movement

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050729

positive regulation of inflammatory response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048870

cell motility

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046677

response to antibiotic

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:12464608[6]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:109169

P

has_regulation_target:(MGI:MGI:96683)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:12464608[6]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:96683)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045786

negative regulation of cell cycle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045766

positive regulation of angiogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045766

positive regulation of angiogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2583

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045765

regulation of angiogenesis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045648

positive regulation of erythrocyte differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:1409581[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2583

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043536

positive regulation of blood vessel endothelial cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042981

regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

F

Seeded From UniProt

complete

enables

GO:0035035

histone acetyltransferase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2583

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030578

PML body organization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030335

positive regulation of cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2583

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010715

regulation of extracellular matrix disassembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2583

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010595

positive regulation of endothelial cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2583

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006366

transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006357

regulation of transcription by RNA polymerase II

PMID:15541767[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005667

transcription factor complex

PMID:12464608[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12119294[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2583

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:12119294[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:15541767[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:12119294[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P14921

F

Seeded From UniProt

complete

involved_in

GO:1904996

positive regulation of leukocyte adhesion to vascular endothelial cell

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

involved_in

GO:0061614

pri-miRNA transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

involved_in

GO:0051272

positive regulation of cellular component movement

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

involved_in

GO:0050729

positive regulation of inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

involved_in

GO:0048870

cell motility

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

involved_in

GO:0045766

positive regulation of angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

involved_in

GO:0045765

regulation of angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

involved_in

GO:0045648

positive regulation of erythrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

involved_in

GO:0043536

positive regulation of blood vessel endothelial cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

F

Seeded From UniProt

complete

involved_in

GO:0030578

PML body organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

involved_in

GO:0010595

positive regulation of endothelial cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P14921
ensembl:ENSP00000376436

F

Seeded From UniProt

complete

involved_in

GO:0070555

response to interleukin-1

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0070301

cellular response to hydrogen peroxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0060055

angiogenesis involved in wound healing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0045766

positive regulation of angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0044849

estrous cycle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

F

Seeded From UniProt

complete

enables

GO:0035035

histone acetyltransferase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

F

Seeded From UniProt

complete

involved_in

GO:0034616

response to laminar fluid shear stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0021983

pituitary gland development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0021854

hypothalamus development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0010715

regulation of extracellular matrix disassembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0009612

response to mechanical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0009611

response to wounding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

C

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41156
ensembl:ENSRNOP00000011925

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000418
InterPro:IPR016311

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003118

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000418

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000418
InterPro:IPR003118

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Song, KS et al. (2012) c-Ets1 inhibits the interaction of NF-κB and CREB, and downregulates IL-1β-induced MUC5AC overproduction during airway inflammation. Mucosal Immunol 5 207-15 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Hadri, L et al. (2002) Basal transcription of the mouse sarco(endo)plasmic reticulum Ca2+-ATPase type 3 gene in endothelial cells is controlled by Ets-1 and Sp1. J. Biol. Chem. 277 36471-8 PubMed GONUTS page
  3. Pufall, MA et al. (2005) Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region. Science 309 142-5 PubMed GONUTS page
  4. Giese, K et al. (1995) Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev. 9 995-1008 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. 6.0 6.1 6.2 Elvert, G et al. (2003) Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1). J. Biol. Chem. 278 7520-30 PubMed GONUTS page
  7. Hagman, J & Grosschedl, R (1992) An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene. Proc. Natl. Acad. Sci. U.S.A. 89 8889-93 PubMed GONUTS page
  8. 8.0 8.1 Petit, FG et al. () The regulation of COUP-TFII gene expression by Ets-1 is enhanced by the steroid receptor co-activators. Mech. Ageing Dev. 125 719-32 PubMed GONUTS page