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HUMAN:CDC5L
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | CDC5L (synonyms: KIAA0432, PCDC5RP) | |
| Protein Name(s) | Cell division cycle 5-like protein
Cdc5-like protein Pombe cdc5-related protein | |
| External Links | ||
| UniProt | Q99459 | |
| EMBL | U86753 AB007892 AY518540 AL133262 AL353588 AL353588 AL133262 BC001568 D85423 | |
| CCDS | CCDS4912.1 | |
| RefSeq | NP_001244.1 | |
| UniGene | Hs.485471 | |
| PDB | 2DIM 2DIN | |
| PDBsum | 2DIM 2DIN | |
| ProteinModelPortal | Q99459 | |
| SMR | Q99459 | |
| BioGrid | 107424 | |
| DIP | DIP-31731N | |
| IntAct | Q99459 | |
| MINT | MINT-133723 | |
| STRING | 9606.ENSP00000360532 | |
| PhosphoSite | Q99459 | |
| DMDM | 73619933 | |
| MaxQB | Q99459 | |
| PaxDb | Q99459 | |
| PeptideAtlas | Q99459 | |
| PRIDE | Q99459 | |
| DNASU | 988 | |
| Ensembl | ENST00000371477 | |
| GeneID | 988 | |
| KEGG | hsa:988 | |
| UCSC | uc003oxl.3 | |
| CTD | 988 | |
| GeneCards | GC06P044402 | |
| HGNC | HGNC:1743 | |
| HPA | CAB012275 HPA006302 HPA011361 | |
| MIM | 602868 | |
| neXtProt | NX_Q99459 | |
| PharmGKB | PA26270 | |
| eggNOG | COG5147 | |
| GeneTree | ENSGT00550000074922 | |
| HOGENOM | HOG000182446 | |
| HOVERGEN | HBG052766 | |
| InParanoid | Q99459 | |
| KO | K12860 | |
| OMA | FKRLRQQ | |
| OrthoDB | EOG7JDQWW | |
| PhylomeDB | Q99459 | |
| TreeFam | TF101061 | |
| Reactome | REACT_467 | |
| ChiTaRS | CDC5L | |
| EvolutionaryTrace | Q99459 | |
| GeneWiki | CDC5L | |
| GenomeRNAi | 988 | |
| NextBio | 4146 | |
| PMAP-CutDB | Q99459 | |
| PRO | PR:Q99459 | |
| Proteomes | UP000005640 | |
| Bgee | Q99459 | |
| CleanEx | HS_CDC5L | |
| Genevestigator | Q99459 | |
| GO | GO:0071013 GO:0005737 GO:0016020 GO:0016607 GO:0005730 GO:0005634 GO:0000974 GO:0003682 GO:0003677 GO:0044822 GO:0071987 GO:0000398 GO:0006355 GO:0072422 GO:0006351 | |
| Gene3D | 1.10.10.60 | |
| InterPro | IPR021786 IPR009057 IPR017930 IPR001005 | |
| Pfam | PF11831 | |
| SMART | SM00717 | |
| SUPFAM | SSF46689 | |
| PROSITE | PS51294 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Figure 4a found that PCDC5RP was exclusively in the cytoplasm in transfected CV-1 cells. |
complete | |||||
|
part_of |
GO:0071007 |
U2-type catalytic step 2 spliceosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000398 |
mRNA splicing, via spliceosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072422 |
signal transduction involved in DNA damage checkpoint |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0005662 |
DNA replication factor A complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0071987 |
WD40-repeat domain binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0071013 |
catalytic step 2 spliceosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000974 |
Prp19 complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000398 |
mRNA splicing, via spliceosome |
ECO:0000305 |
curator inference used in manual assertion |
GO:0071013 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1990646 |
cellular response to prolactin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990090 |
cellular response to nerve growth factor stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1904568 |
cellular response to wortmannin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071352 |
cellular response to interleukin-2 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0044344 |
cellular response to fibroblast growth factor stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043522 |
leucine zipper domain binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008157 |
protein phosphatase 1 binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0001222 |
transcription corepressor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000278 |
mitotic cell cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08837 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-72160 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0000398 |
mRNA splicing, via spliceosome |
Reactome:R-HSA-72163 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005681 |
spliceosomal complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Bernstein, HS & Coughlin, SR (1997) Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. J. Biol. Chem. 272 5833-7 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Bertram, K et al. (2017) Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature 542 318-323 PubMed GONUTS page
- ↑ 3.0 3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Lei, XH et al. (2000) Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein. J. Cell. Sci. 113 Pt 24 4523-31 PubMed GONUTS page
- ↑ 5.0 5.1 Maréchal, A et al. (2014) PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Mol. Cell 53 235-46 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ Grillari, J et al. (2005) SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly. Nucleic Acids Res. 33 6868-83 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Grote, M et al. (2010) Molecular architecture of the human Prp19/CDC5L complex. Mol. Cell. Biol. 30 2105-19 PubMed GONUTS page
- ↑ 9.0 9.1 Jurica, MS et al. (2002) Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA 8 426-39 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ Hirayama, T & Shinozaki, K (1996) A cdc5+ homolog of a higher plant, Arabidopsis thaliana. Proc. Natl. Acad. Sci. U.S.A. 93 13371-6 PubMed GONUTS page
c
- GO:0071013 ! catalytic step 2 spliceosome
- Catarrhini
- GO:0044344 ! cellular response to fibroblast growth factor stimulus
- GO:0071352 ! cellular response to interleukin-2
- GO:1904568 ! cellular response to wortmannin
- GO:1990090 ! cellular response to nerve growth factor stimulus
- GO:1990646 ! cellular response to prolactin
- GO:0007049 ! cell cycle
- Chordata
- Craniata
- GO:0005737 ! cytoplasm
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