HUMAN:HIF1A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HIF1A (synonyms: BHLHE78, MOP1, PASD8)
Protein Name(s)	Hypoxia-inducible factor 1-alpha HIF-1-alpha HIF1-alpha ARNT-interacting protein Basic-helix-loop-helix-PAS protein MOP1 Class E basic helix-loop-helix protein 78 bHLHe78 Member of PAS protein 1 PAS domain-containing protein 8
External Links
UniProt	Q16665
EMBL	U22431 U29165 AF050127 AF050115 AF050116 AF050117 AF050118 AF050119 AF050120 AF050121 AF050122 AF050123 AF050124 AF050125 AF050126 FJ790247 AF207601 AF207602 AF208487 AF304431 AB073325 BT009776 AL137129 BC012527
CCDS	CCDS58324.1 CCDS9753.1 CCDS9754.1
PIR	I38972
RefSeq	NP_001230013.1 NP_001521.1 NP_851397.1
UniGene	Hs.597216 Hs.719495
PDB	1D7G 1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J
PDBsum	1D7G 1H2K 1H2L 1H2M 1L3E 1L8C 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J
DisProt	DP00262
ProteinModelPortal	Q16665
SMR	Q16665
BioGrid	109338
DIP	DIP-29722N
IntAct	Q16665
MINT	MINT-133270
STRING	9606.ENSP00000338018
BindingDB	Q16665
ChEMBL	CHEMBL2221345
DrugBank	DB01136
PhosphoSite	Q16665
DMDM	2498017
MaxQB	Q16665
PaxDb	Q16665
PRIDE	Q16665
DNASU	3091
Ensembl	ENST00000323441 ENST00000337138 ENST00000539097
GeneID	3091
KEGG	hsa:3091
UCSC	uc001xfq.2 uc021rua.1
CTD	3091
GeneCards	GC14P062162
HGNC	HGNC:4910
HPA	CAB017442 HPA001275
MIM	603348
neXtProt	NX_Q16665
PharmGKB	PA29283
eggNOG	NOG289264
GeneTree	ENSGT00760000118788
HOGENOM	HOG000234306
HOVERGEN	HBG060456
InParanoid	Q16665
KO	K08268
OMA	QNAQRKR
OrthoDB	EOG7JDQX8
PhylomeDB	Q16665
TreeFam	TF317772
Reactome	REACT_118780 REACT_120916 REACT_121092 REACT_121226 REACT_24941
SignaLink	Q16665
ChiTaRS	HIF1A
EvolutionaryTrace	Q16665
GeneWiki	HIF1A
GenomeRNAi	3091
NextBio	12265
PRO	PR:Q16665
Proteomes	UP000005640
Bgee	Q16665
CleanEx	HS_HIF1A
ExpressionAtlas	Q16665
Genevestigator	Q16665
GO	GO:0005737 GO:0005829 GO:0031514 GO:0005730 GO:0005654 GO:0005634 GO:0090575 GO:0005667 GO:0019899 GO:0035035 GO:0051879 GO:0035257 GO:0046982 GO:0019901 GO:0001077 GO:0003705 GO:0001076 GO:0043565 GO:0003700 GO:0004871 GO:0008134 GO:0000989 GO:0031625 GO:0001525 GO:0019896 GO:0001922 GO:0003208 GO:0051216 GO:0006879 GO:0071456 GO:0071347 GO:0021987 GO:0032963 GO:0002248 GO:0048546 GO:0071542 GO:0051541 GO:0035162 GO:0001892 GO:0061030 GO:0001837 GO:0042593 GO:0001947 GO:0042541 GO:0060574 GO:0006089 GO:0007595 GO:0042789 GO:0046716 GO:0030502 GO:0045926 GO:2001054 GO:1903377 GO:0070244 GO:0032007 GO:0001755 GO:0021502 GO:0007219 GO:0003151 GO:0032364 GO:0045766 GO:0032722 GO:0070101 GO:0001938 GO:0010634 GO:0045648 GO:0045821 GO:0046886 GO:0035774 GO:0002052 GO:0051000 GO:0010870 GO:0045944 GO:0061419 GO:0045893 GO:0030949 GO:0010575 GO:0010468 GO:0061418 GO:0043619 GO:0006355 GO:0032909 GO:0001666 GO:0014850 GO:0061298 GO:0007165 GO:0010573 GO:0008542
InterPro	IPR011598 IPR001321 IPR014887 IPR021537 IPR001610 IPR000014 IPR013767
Pfam	PF11413 PF08778 PF00989
PRINTS	PR01080
SMART	SM00353 SM00086 SM00091
SUPFAM	SSF47459 SSF55785
TIGRFAMs	TIGR00229
PROSITE	PS50888 PS50112

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0071456		PMID:20412594^[1]	ECO:0000314					Figure 2 shows the increase in lactate production with hypoxia by lactate dehydrogenase in comparison to normoxia.	complete
	GO:0071456	cellular response to hypoxia	PMID:10758161^[2]	ECO:0000270			P		Figure 1	complete
	GO:0010508	positive regulation of autophagy	PMID:21412054^[3]	ECO:0000315			P		Fig 5. When HIF-1α is knockdown, LC3B cleavage, a well characterized marker for autophagy, is reduced in response to doxorubicin and daunorubicin.	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[4]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001321 InterPro:IPR011598	F		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:19141645^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456) regulates_expression_of:(ENSEMBL:ENSG00000199038)\|part_of(GO:0071456) regulates_expression_of:(ENSEMBL:ENSG00000199143)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:19782034^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(ENSEMBL:ENSG00000199038)	Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:19782034^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000199038)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:19782034^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000199038)	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:19782034^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:19782034^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0071456) regulates_expression_of:(ENSEMBL:ENSG00000199038)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P97481	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:22886504^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000199038) part_of:(GO:0071456) occurs_in:(CL:0002591)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20972335^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071456) part_of:(CL:0000071)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:14594809^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:14594809^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P45481	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24244340^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000207954) occurs_in:(CL:2000008)	Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:15629713^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:26879375^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:25043030^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25043030^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:25043030^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:15459207^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0010021) has_regulation_target:(UniProtKB:P04764)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:26879375^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000128052) occurs_in:(CL:0000071)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:26879375^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000071)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:15629713^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	PMID:28296633^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24048733^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24048733^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0001666	response to hypoxia	PMID:22292025^[17]	ECO:0000314			P		Fig 1A as hypoxia occurs, levels of HIF-1alpha increase	complete CACAO 3761
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:24048733^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:24048733^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:21817107^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000062716) occurs_in:(CL:0000359) occurs_in:(UBERON:0002060)	Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:24983504^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071456) regulates_transcription_of:(ENSEMBL:ENSG00000062716)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:24983504^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	part_of:(GO:0071456) has_regulation_target:(ENSEMBL:ENSG00000062716)	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61221	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22848707^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:8756616^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:7539918^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	PMID:24899725^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	PMID:12958148^[24]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070101	positive regulation of chemokine-mediated signaling pathway	PMID:17178876^[25]	ECO:0000305	curator inference used in manual assertion	GO:0010870	P		Seeded From UniProt	complete
involved_in	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	PMID:19652095^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9H4X1)	Seeded From UniProt	complete
involved_in	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	PMID:22735262^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:9079689^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051541	elastin metabolic process	PMID:18037992^[29]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61221	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9079689^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27540	F		Seeded From UniProt	complete
involved_in	GO:0046886	positive regulation of hormone biosynthetic process	PMID:1448077^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:8089148^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045821	positive regulation of glycolytic process	PMID:8089148^[31]	ECO:0000305	curator inference used in manual assertion	GO:0043619	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:8756616^[21]	ECO:0000305	curator inference used in manual assertion	GO:0010575	P		Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	PMID:1448077^[30]	ECO:0000305	curator inference used in manual assertion	GO:0046886	P		Seeded From UniProt	complete
involved_in	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	PMID:8387214^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	PMID:8089148^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0043565	sequence-specific DNA binding	PMID:7539918^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0043565	sequence-specific DNA binding	PMID:8756616^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0043565	sequence-specific DNA binding	PMID:9079689^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042789	mRNA transcription by RNA polymerase II	PMID:7539918^[22]	ECO:0000305	curator inference used in manual assertion	GO:0000981	P		Seeded From UniProt	complete
involved_in	GO:0032963	collagen metabolic process	PMID:18037992^[29]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61221	P		Seeded From UniProt	complete
involved_in	GO:0032909	regulation of transforming growth factor beta2 production	PMID:12411310^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:12958148^[24]	ECO:0000305	curator inference used in manual assertion	GO:0010573	P		Seeded From UniProt	complete
involved_in	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:8756616^[21]	ECO:0000305	curator inference used in manual assertion	GO:0010575	P		Seeded From UniProt	complete
involved_in	GO:0010870	positive regulation of receptor biosynthetic process	PMID:17178876^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	PMID:18037992^[29]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61221	P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:8756616^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010573	vascular endothelial growth factor production	PMID:12958148^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:7539918^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27540	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:12411310^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19651758^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8089148^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:7539918^[22]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
contributes_to	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:8756616^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:9079689^[28]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:8387214^[32]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
involved_in	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	PMID:18037992^[29]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61221	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:8756616^[21]	ECO:0000305	curator inference used in manual assertion	GO:0010575	P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:18037992^[29]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61221	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:12411310^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:8756616^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032364	oxygen homeostasis	PMID:16956324^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:11573933^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:19528298^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:20889502^[38]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:20810912^[39]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	PMID:24681946^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:12239177^[41]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HBZ2	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11573933^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:21056661^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q99801)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9887100^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035257	nuclear hormone receptor binding	PMID:18658046^[44]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35398	F		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	PMID:15261140^[45]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:11641274^[46]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P40337	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:20889502^[38]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9H4B4	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11641274^[46]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NWT6	F		Seeded From UniProt	complete
involved_in	GO:0019896	axonal transport of mitochondrion	PMID:19528298^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:18658046^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:18419598^[47]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:15261140^[45]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:24681946^[40]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18658046^[44]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20810912^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15261140^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:18658046^[44]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:9887100^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:18419598^[47]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:15261140^[45]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[48]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039411 FB:FBgn0262139 FB:FBgn0266411 MGI:MGI:106918 MGI:MGI:109169 MGI:MGI:2664186 PANTHER:PTN001127032 RGD:61928 RGD:68404 RGD:70332 UniProtKB:Q16665 UniProtKB:Q8IUM7 UniProtKB:Q99814 WB:WBGene00000521 WB:WBGene00001851	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[48]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039411 PANTHER:PTN000548738 UniProtKB:Q9Y2N7	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[48]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004666 FB:FBgn0039411 FB:FBgn0262139 FB:FBgn0266411 MGI:MGI:106918 MGI:MGI:109169 MGI:MGI:109205 MGI:MGI:1351610 MGI:MGI:1859778 MGI:MGI:2664186 MGI:MGI:98306 MGI:MGI:98307 PANTHER:PTN000548738 RGD:61928 RGD:68404 RGD:70332 UniProtKB:Q16665 UniProtKB:Q9XTA5 WB:WBGene00001851	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[48]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106918 MGI:MGI:2664186 PANTHER:PTN000548738 UniProtKB:Q8IUM7	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:9576906^[49]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00327	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17981124^[50]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9P0U3	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:11782478^[51]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:9576906^[49]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O00327	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11782478^[51]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:11782478^[51]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019896	C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A8P8 ensembl:ENSRNOP00000042230	P		Seeded From UniProt	complete
involved_in	GO:2001054	negative regulation of mesenchymal cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:1903715	regulation of aerobic respiration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:1903599	positive regulation of autophagy of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0071542	dopaminergic neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	F		Seeded From UniProt	complete
involved_in	GO:0070244	negative regulation of thymocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
	GO:0001666	response to hypoxia	PMID:22848707^[20]	ECO:0000315			P		Figure 6. Shows a favoring of aerobic glycolysis in the immortalized lymphoblastoid cell lines (LCL) when compared to both CD40+IL4 activated cells and newly Epstein-Barr Virus-infected B-cells. In addition to the increased levels of lactate and pyruvate, increased ROS levels were found in LCL's in comparison to the CD40+IL4 and EBV B-Cell cell lines.	complete CACAO 9656
involved_in	GO:0070243	regulation of thymocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
	GO:0005634	nucleus	PMID:22848707^[20]	ECO:0000314			C		Figure 4	complete CACAO 10098
involved_in	GO:0061298	retina vasculature development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0061072	iris morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0060574	intestinal epithelial cell maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0051541	elastin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0048593	camera-type eye morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0048546	digestive tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	F		Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0045926	negative regulation of growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0042541	hemoglobin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0035162	embryonic hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0032963	collagen metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0032364	oxygen homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	C		Seeded From UniProt	complete
involved_in	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0030502	negative regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0021502	neural fold elevation formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	C		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0014850	response to muscle activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0007595	lactation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0006110	regulation of glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0006089	lactate metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	F		Seeded From UniProt	complete
involved_in	GO:0003208	cardiac ventricle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0001944	vasculature development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0001922	B-1 B cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0001892	embryonic placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61221 ensembl:ENSMUSP00000021530	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001321	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001321	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001321 InterPro:IPR013767	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	PMID:18254728^[52]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032722	positive regulation of chemokine production	PMID:18370914^[53]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:15261140^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15261140^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	Reactome:R-HSA-1234174	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	Reactome:R-HSA-8956106	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8956106 Reactome:R-HSA-8956103 Reactome:R-HSA-8857583 Reactome:R-HSA-6781797 Reactome:R-HSA-1234183 Reactome:R-HSA-1234177 Reactome:R-HSA-1234175 Reactome:R-HSA-1234164 Reactome:R-HSA-1234163 Reactome:R-HSA-1234161 Reactome:R-HSA-1234159	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-2065560 Reactome:R-HSA-8848812 Reactome:R-HSA-6790036 Reactome:R-HSA-1234181 Reactome:R-HSA-1234175 Reactome:R-HSA-1234172 Reactome:R-HSA-1234171 Reactome:R-HSA-1234169 Reactome:R-HSA-1234167 Reactome:R-HSA-1234161	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sedoris, KC et al. (2010) Hypoxia induces differential translation of enolase/MBP-1. BMC Cancer 10 157 PubMed GONUTS page
↑ Sutter, CH et al. (2000) Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc. Natl. Acad. Sci. U.S.A. 97 4748-53 PubMed GONUTS page
↑ Culver, C et al. (2011) HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs. Cell Cycle 10 1249-60 PubMed GONUTS page
↑ ^4.0 ^4.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Crosby, ME et al. (2009) MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res. 69 1221-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Huang, X et al. (2009) Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol. Cell 35 856-67 PubMed GONUTS page
↑ Gou, D et al. (2012) miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia. Am. J. Physiol. Lung Cell Mol. Physiol. 303 L682-91 PubMed GONUTS page
↑ Ghosh, G et al. (2010) Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis. J. Clin. Invest. 120 4141-54 PubMed GONUTS page
↑ ^9.0 ^9.1 De Guzman, RN et al. (2004) Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites. J. Biol. Chem. 279 3042-9 PubMed GONUTS page
↑ Sen, A et al. (2013) MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1. PLoS ONE 8 e78684 PubMed GONUTS page
↑ ^11.0 ^11.1 Sánchez-Puig, N et al. (2005) Binding of natively unfolded HIF-1alpha ODD domain to p53. Mol. Cell 17 11-21 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Zhou, Y et al. (2016) Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway. Am. J. Physiol., Cell Physiol. 310 C305-17 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Li, B et al. (2014) Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature 513 251-5 PubMed GONUTS page
↑ Mizukami, Y et al. (2004) ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. J. Biol. Chem. 279 50120-31 PubMed GONUTS page
↑ Miles, AL et al. (2017) The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels. Elife 6 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Roy, A et al. (2013) Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis. Am. J. Physiol., Cell Physiol. 305 C1021-32 PubMed GONUTS page
↑ Deng, S et al. (2012) UCP2 inhibits ROS-mediated apoptosis in A549 under hypoxic conditions. PLoS ONE 7 e30714 PubMed GONUTS page
↑ Wang, M et al. (2011) MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities. Arterioscler. Thromb. Vasc. Biol. 31 2044-53 PubMed GONUTS page
↑ ^19.0 ^19.1 Liu, Y et al. (2014) A feedback regulatory loop between HIF-1α and miR-21 in response to hypoxia in cardiomyocytes. FEBS Lett. 588 3137-46 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Darekar, S et al. (2012) Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect. PLoS ONE 7 e42072 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 ^21.7 Forsythe, JA et al. (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16 4604-13 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 Wang, GL et al. (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. U.S.A. 92 5510-4 PubMed GONUTS page
↑ Parsanejad, M et al. (2014) Regulation of the VHL/HIF-1 pathway by DJ-1. J. Neurosci. 34 8043-50 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Jung, YJ et al. (2003) IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 17 2115-7 PubMed GONUTS page
↑ ^25.0 ^25.1 Wilson, JL et al. (2006) Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1. Cancer Res. 66 11802-7 PubMed GONUTS page
↑ An, X et al. (2009) Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. Circulation 120 617-27 PubMed GONUTS page
↑ Li, Q et al. (2012) CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression. Biochem. Biophys. Res. Commun. 423 895-9 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 Hogenesch, JB et al. (1997) Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J. Biol. Chem. 272 8581-93 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 ^29.4 Higgins, DF et al. (2007) Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J. Clin. Invest. 117 3810-20 PubMed GONUTS page
↑ ^30.0 ^30.1 Semenza, GL & Wang, GL (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12 5447-54 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 ^31.3 Semenza, GL et al. (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269 23757-63 PubMed GONUTS page
↑ ^32.0 ^32.1 Wang, GL & Semenza, GL (1993) General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc. Natl. Acad. Sci. U.S.A. 90 4304-8 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 Zhang, H et al. (2003) Cellular response to hypoxia involves signaling via Smad proteins. Blood 101 2253-60 PubMed GONUTS page
↑ Fisher, CD et al. (2009) Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Drug Metab. Dispos. 37 2087-94 PubMed GONUTS page
↑ Huang, J et al. (2007) IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity. Biochem. J. 401 341-52 PubMed GONUTS page
↑ ^36.0 ^36.1 Hara, S et al. (2001) Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha. Biochem. Biophys. Res. Commun. 287 808-13 PubMed GONUTS page
↑ ^37.0 ^37.1 Li, Y et al. (2009) HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. J. Cell Biol. 185 1065-81 PubMed GONUTS page
↑ ^38.0 ^38.1 Xu, D et al. (2010) Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha. J. Biol. Chem. 285 38944-50 PubMed GONUTS page
↑ ^39.0 ^39.1 Chen, B et al. (2010) Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. Am. J. Physiol., Cell Physiol. 299 C968-76 PubMed GONUTS page
↑ ^40.0 ^40.1 Seo, KS et al. (2015) SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation. Oncogene 34 1354-62 PubMed GONUTS page
↑ Stolze, I et al. (2002) Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. Blood 100 2623-8 PubMed GONUTS page
↑ Mitani, T et al. (2011) Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment. J. Steroid Biochem. Mol. Biol. 123 58-64 PubMed GONUTS page
↑ ^43.0 ^43.1 Bhattacharya, S et al. (1999) Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev. 13 64-75 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 ^44.3 Kim, EJ et al. (2008) Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling. Arterioscler. Thromb. Vasc. Biol. 28 1796-802 PubMed GONUTS page
↑ ^45.0 ^45.1 ^45.2 ^45.3 ^45.4 ^45.5 Kung, AL et al. (2004) Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6 33-43 PubMed GONUTS page
↑ ^46.0 ^46.1 Mahon, PC et al. (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15 2675-86 PubMed GONUTS page
↑ ^47.0 ^47.1 Li, Z et al. (2008) Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells. J. Cell. Mol. Med. 12 569-79 PubMed GONUTS page
↑ ^48.0 ^48.1 ^48.2 ^48.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^49.0 ^49.1 Hogenesch, JB et al. (1998) The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci. U.S.A. 95 5474-9 PubMed GONUTS page
↑ Cheng, J et al. (2007) SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell 131 584-95 PubMed GONUTS page
↑ ^51.0 ^51.1 ^51.2 Woods, SL & Whitelaw, ML (2002) Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J. Biol. Chem. 277 10236-43 PubMed GONUTS page
↑ Hold, GL & El-Omar, EM (2008) Genetic aspects of inflammation and cancer. Biochem. J. 410 225-35 PubMed GONUTS page
↑ Chang, EI et al. (2007) Hypoxia, hormones, and endothelial progenitor cells in hemangioma. Lymphat Res Biol 5 237-43 PubMed GONUTS page

[PMID:20412594-1] Sedoris, KC et al. (2010) Hypoxia induces differential translation of enolase/MBP-1. BMC Cancer 10 157 PubMed GONUTS page

[PMID:10758161-2] Sutter, CH et al. (2000) Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc. Natl. Acad. Sci. U.S.A. 97 4748-53 PubMed GONUTS page

[PMID:21412054-3] Culver, C et al. (2011) HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs. Cell Cycle 10 1249-60 PubMed GONUTS page

[PMID:19274049-4] 4.0 ^4.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:19141645-5] Crosby, ME et al. (2009) MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res. 69 1221-9 PubMed GONUTS page

[PMID:19782034-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Huang, X et al. (2009) Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol. Cell 35 856-67 PubMed GONUTS page

[PMID:22886504-7] Gou, D et al. (2012) miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia. Am. J. Physiol. Lung Cell Mol. Physiol. 303 L682-91 PubMed GONUTS page

[PMID:20972335-8] Ghosh, G et al. (2010) Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis. J. Clin. Invest. 120 4141-54 PubMed GONUTS page

[PMID:14594809-9] 9.0 ^9.1 De Guzman, RN et al. (2004) Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites. J. Biol. Chem. 279 3042-9 PubMed GONUTS page

[PMID:24244340-10] Sen, A et al. (2013) MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1. PLoS ONE 8 e78684 PubMed GONUTS page

[PMID:15629713-11] 11.0 ^11.1 Sánchez-Puig, N et al. (2005) Binding of natively unfolded HIF-1alpha ODD domain to p53. Mol. Cell 17 11-21 PubMed GONUTS page

[PMID:26879375-12] 12.0 ^12.1 ^12.2 Zhou, Y et al. (2016) Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway. Am. J. Physiol., Cell Physiol. 310 C305-17 PubMed GONUTS page

[PMID:25043030-13] 13.0 ^13.1 ^13.2 Li, B et al. (2014) Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature 513 251-5 PubMed GONUTS page

[PMID:15459207-14] Mizukami, Y et al. (2004) ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. J. Biol. Chem. 279 50120-31 PubMed GONUTS page

[PMID:28296633-15] Miles, AL et al. (2017) The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels. Elife 6 PubMed GONUTS page

[PMID:24048733-16] 16.0 ^16.1 ^16.2 ^16.3 Roy, A et al. (2013) Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis. Am. J. Physiol., Cell Physiol. 305 C1021-32 PubMed GONUTS page

[PMID:22292025-17] Deng, S et al. (2012) UCP2 inhibits ROS-mediated apoptosis in A549 under hypoxic conditions. PLoS ONE 7 e30714 PubMed GONUTS page

[PMID:21817107-18] Wang, M et al. (2011) MicroRNA-21 regulates vascular smooth muscle cell function via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extremities. Arterioscler. Thromb. Vasc. Biol. 31 2044-53 PubMed GONUTS page

[PMID:24983504-19] 19.0 ^19.1 Liu, Y et al. (2014) A feedback regulatory loop between HIF-1α and miR-21 in response to hypoxia in cardiomyocytes. FEBS Lett. 588 3137-46 PubMed GONUTS page

[PMID:22848707-20] 20.0 ^20.1 ^20.2 Darekar, S et al. (2012) Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect. PLoS ONE 7 e42072 PubMed GONUTS page

[PMID:8756616-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 ^21.7 Forsythe, JA et al. (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16 4604-13 PubMed GONUTS page

[PMID:7539918-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 Wang, GL et al. (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. U.S.A. 92 5510-4 PubMed GONUTS page

[PMID:24899725-23] Parsanejad, M et al. (2014) Regulation of the VHL/HIF-1 pathway by DJ-1. J. Neurosci. 34 8043-50 PubMed GONUTS page

[PMID:12958148-24] 24.0 ^24.1 ^24.2 Jung, YJ et al. (2003) IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 17 2115-7 PubMed GONUTS page

[PMID:17178876-25] 25.0 ^25.1 Wilson, JL et al. (2006) Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1. Cancer Res. 66 11802-7 PubMed GONUTS page

[PMID:19652095-26] An, X et al. (2009) Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. Circulation 120 617-27 PubMed GONUTS page

[PMID:22735262-27] Li, Q et al. (2012) CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression. Biochem. Biophys. Res. Commun. 423 895-9 PubMed GONUTS page

[PMID:9079689-28] 28.0 ^28.1 ^28.2 ^28.3 Hogenesch, JB et al. (1997) Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J. Biol. Chem. 272 8581-93 PubMed GONUTS page

[PMID:18037992-29] 29.0 ^29.1 ^29.2 ^29.3 ^29.4 Higgins, DF et al. (2007) Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J. Clin. Invest. 117 3810-20 PubMed GONUTS page

[PMID:1448077-30] 30.0 ^30.1 Semenza, GL & Wang, GL (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12 5447-54 PubMed GONUTS page

[PMID:8089148-31] 31.0 ^31.1 ^31.2 ^31.3 Semenza, GL et al. (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269 23757-63 PubMed GONUTS page

[PMID:8387214-32] 32.0 ^32.1 Wang, GL & Semenza, GL (1993) General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc. Natl. Acad. Sci. U.S.A. 90 4304-8 PubMed GONUTS page

[PMID:12411310-33] 33.0 ^33.1 ^33.2 Zhang, H et al. (2003) Cellular response to hypoxia involves signaling via Smad proteins. Blood 101 2253-60 PubMed GONUTS page

[PMID:19651758-34] Fisher, CD et al. (2009) Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Drug Metab. Dispos. 37 2087-94 PubMed GONUTS page

[PMID:16956324-35] Huang, J et al. (2007) IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity. Biochem. J. 401 341-52 PubMed GONUTS page

[PMID:11573933-36] 36.0 ^36.1 Hara, S et al. (2001) Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha. Biochem. Biophys. Res. Commun. 287 808-13 PubMed GONUTS page

[PMID:19528298-37] 37.0 ^37.1 Li, Y et al. (2009) HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. J. Cell Biol. 185 1065-81 PubMed GONUTS page

[PMID:20889502-38] 38.0 ^38.1 Xu, D et al. (2010) Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha. J. Biol. Chem. 285 38944-50 PubMed GONUTS page

[PMID:20810912-39] 39.0 ^39.1 Chen, B et al. (2010) Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. Am. J. Physiol., Cell Physiol. 299 C968-76 PubMed GONUTS page

[PMID:24681946-40] 40.0 ^40.1 Seo, KS et al. (2015) SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation. Oncogene 34 1354-62 PubMed GONUTS page

[PMID:12239177-41] Stolze, I et al. (2002) Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells. Blood 100 2623-8 PubMed GONUTS page

[PMID:21056661-42] Mitani, T et al. (2011) Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment. J. Steroid Biochem. Mol. Biol. 123 58-64 PubMed GONUTS page

[PMID:9887100-43] 43.0 ^43.1 Bhattacharya, S et al. (1999) Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev. 13 64-75 PubMed GONUTS page

[PMID:18658046-44] 44.0 ^44.1 ^44.2 ^44.3 Kim, EJ et al. (2008) Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling. Arterioscler. Thromb. Vasc. Biol. 28 1796-802 PubMed GONUTS page

[PMID:15261140-45] 45.0 ^45.1 ^45.2 ^45.3 ^45.4 ^45.5 Kung, AL et al. (2004) Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6 33-43 PubMed GONUTS page

[PMID:11641274-46] 46.0 ^46.1 Mahon, PC et al. (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15 2675-86 PubMed GONUTS page

[PMID:18419598-47] 47.0 ^47.1 Li, Z et al. (2008) Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells. J. Cell. Mol. Med. 12 569-79 PubMed GONUTS page

[PMID:21873635-48] 48.0 ^48.1 ^48.2 ^48.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9576906-49] 49.0 ^49.1 Hogenesch, JB et al. (1998) The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci. U.S.A. 95 5474-9 PubMed GONUTS page

[PMID:17981124-50] Cheng, J et al. (2007) SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell 131 584-95 PubMed GONUTS page

[PMID:11782478-51] 51.0 ^51.1 ^51.2 Woods, SL & Whitelaw, ML (2002) Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. J. Biol. Chem. 277 10236-43 PubMed GONUTS page

[PMID:18254728-52] Hold, GL & El-Omar, EM (2008) Genetic aspects of inflammation and cancer. Biochem. J. 410 225-35 PubMed GONUTS page

[PMID:18370914-53] Chang, EI et al. (2007) Hypoxia, hormones, and endothelial progenitor cells in hemangioma. Lymphat Res Biol 5 237-43 PubMed GONUTS page

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HUMAN:HIF1A

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