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PMID:22848707
| Citation |
Darekar, S, Georgiou, K, Yurchenko, M, Yenamandra, SP, Chachami, G, Simos, G, Klein, G and Kashuba, E (2012) Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect. PLoS ONE 7:e42072 |
|---|---|
| Abstract |
Epstein-Barr virus (EBV) encodes six nuclear transformation-associated proteins that induce extensive changes in cellular gene expression and signaling and induce B-cell transformation. The role of HIF1A in EBV-induced B-cell immortalization has not been previously studied. |
| Links |
PubMed PMC3407085 Online version:10.1371/journal.pone.0042072 |
| Keywords |
Active Transport, Cell Nucleus; Aerobiosis; B-Lymphocytes/metabolism; B-Lymphocytes/pathology; B-Lymphocytes/virology; Cell Nucleus/metabolism; Cell Transformation, Viral; Epstein-Barr Virus Nuclear Antigens/metabolism; Glycolysis; Herpesvirus 4, Human/physiology; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/chemistry; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; MCF-7 Cells; Procollagen-Proline Dioxygenase/metabolism; Protein Stability; Transcription, Genetic |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0001666: response to hypoxia |
ECO:0000315: |
P |
Figure 6. Shows a favoring of aerobic glycolysis in the immortalized lymphoblastoid cell lines (LCL) when compared to both CD40+IL4 activated cells and newly Epstein-Barr Virus-infected B-cells. In addition to the increased levels of lactate and pyruvate, increased ROS levels were found in LCL's in comparison to the CD40+IL4 and EBV B-Cell cell lines. |
complete | ||||
| GO:0005634: nucleus |
ECO:0000314: |
C |
Figure 4 |
complete | ||||
See also
References
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