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PMID:19652095

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Citation

An, X, Jin, Y, Guo, H, Foo, SY, Cully, BL, Wu, J, Zeng, H, Rosenzweig, A and Li, J (2009) Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. Circulation 120:617-27

Abstract

Response gene to complement 32 (RGC-32) is induced by activation of complement and regulates cell proliferation. To determine the mechanism of RGC-32 in angiogenesis, we examined the role of RGC-32 in hypoxia-related endothelial cell function.

Links

PubMed PMC2837511 Online version:10.1161/CIRCULATIONAHA.108.841502

Keywords

Angiogenesis Inhibitors/genetics; Angiogenesis Inhibitors/physiology; Animals; Anoxia/physiopathology; Apoptosis/physiology; Caenorhabditis elegans Proteins/physiology; Cell Cycle Proteins/genetics; Cell Cycle Proteins/physiology; Cell Movement/physiology; Cell Proliferation; Cells, Cultured; Cyclin E/physiology; Disease Models, Animal; Endothelium, Vascular/cytology; Endothelium, Vascular/pathology; Fibroblast Growth Factor 2/physiology; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Nude; Muscle Proteins/genetics; Muscle Proteins/physiology; Neovascularization, Pathologic/physiopathology; Neovascularization, Physiologic/physiology; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Transcription Factors/physiology; Vascular Endothelial Growth Factor A/physiology; Xenograft Model Antitumor Assays

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:VEGFA

involved_in

GO:0061419: positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • has_input:(UniProtKB:Q9H4X1)

Seeded From UniProt

complete

HUMAN:HIF1A

involved_in

GO:0061419: positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • has_input:(UniProtKB:Q9H4X1)

Seeded From UniProt

complete

HUMAN:RGCC

involved_in

GO:0016525: negative regulation of angiogenesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:RGCC

involved_in

GO:0001937: negative regulation of endothelial cell proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:RGCC

involved_in

GO:2000353: positive regulation of endothelial cell apoptotic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:RGCC

involved_in

GO:0071456: cellular response to hypoxia

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:RGCC

involved_in

GO:0043537: negative regulation of blood vessel endothelial cell migration

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:RGCC

involved_in

GO:0090272: negative regulation of fibroblast growth factor production

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:P09038)

Seeded From UniProt

complete

HUMAN:HIF1A

involved_in

GO:0061419: positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

ECO:0000315: mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q9H4X1)

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:0061419: positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

ECO:0000315: mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q9H4X1)

Seeded From UniProt

complete

See also

References

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