PMID:20412594

Citation	Sedoris, KC, Thomas, SD and Miller, DM (2010) Hypoxia induces differential translation of enolase/MBP-1. BMC Cancer 10:157
Abstract	Hypoxic microenvironments in tumors contribute to transformation, which may alter metabolism, growth, and therapeutic responsiveness. The alpha-enolase gene encodes both a glycolytic enzyme (alpha-enolase) and a DNA-binding tumor suppressor protein, c-myc binding protein (MBP-1). These divergent alpha-enolase gene products play central roles in glucose metabolism and growth regulation and their differential regulation may be critical for tumor adaptation to hypoxia. We have previously shown that MBP-1 and its binding to the c-myc P2 promoter regulates the metabolic and cellular growth changes that occur in response to altered exogenous glucose concentrations.
Links	PubMed PMC2873388 Online version:10.1186/1471-2407-10-157
Keywords	Breast Neoplasms/enzymology; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Cycle/genetics; Cell Growth Processes/genetics; Cell Hypoxia/genetics; Cell Line, Tumor; DNA-Binding Proteins/biosynthesis; DNA-Binding Proteins/genetics; Excitatory Amino Acid Transporter 2/metabolism; Gene Expression Regulation, Neoplastic; Glucose/metabolism; Humans; Lactic Acid/biosynthesis; Phosphopyruvate Hydratase/biosynthesis; Phosphopyruvate Hydratase/genetics; Phosphorylation; Promoter Regions, Genetic; RNA, Messenger/genetics; RNA, Messenger/metabolism; Reactive Oxygen Species/metabolism; Translocation, Genetic; Up-Regulation
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:HIF1A		GO:0071456:	ECO:0000314:				Figure 2 shows the increase in lactate production with hypoxia by lactate dehydrogenase in comparison to normoxia.	complete

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