name: hypoxia-inducible factor-1alpha signaling pathway
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def: "A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia." [GOC:bf, GOC:jc, http://www.sabiosciences.com/pathway.php?sn=HIF1Alpha_Pathway]
synonym: "HIF1alpha pathway" EXACT 
synonym: "hypoxia-inducible factor signaling" EXACT [GOC:bf]
synonym: "hypoxia-inducible factor-1alpha signalling pathway" EXACT 
is_a: GO:0007165 ! signal transduction
relationship: part_of: GO:0071456 ! cellular response to hypoxia
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Pages in category "GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway"
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