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HUMAN:PDK1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PDK1 (synonyms: PDHK1) | |
| Protein Name(s) | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
Pyruvate dehydrogenase kinase isoform 1 PDH kinase 1 | |
| External Links | ||
| UniProt | Q15118 | |
| EMBL | L42450 DQ234350 AK304388 AK312700 AC018712 AC093818 CH471058 CH471058 BC039158 | |
| CCDS | CCDS2250.1 CCDS63059.1 | |
| PIR | I55465 | |
| RefSeq | NP_001265478.1 NP_002601.1 | |
| UniGene | Hs.470633 Hs.733780 | |
| PDB | 2Q8F 2Q8G 2Q8H | |
| PDBsum | 2Q8F 2Q8G 2Q8H | |
| ProteinModelPortal | Q15118 | |
| SMR | Q15118 | |
| BioGrid | 111189 | |
| DIP | DIP-29497N | |
| IntAct | Q15118 | |
| MINT | MINT-2881420 | |
| STRING | 9606.ENSP00000282077 | |
| BindingDB | Q15118 | |
| ChEMBL | CHEMBL4766 | |
| PhosphoSite | Q15118 | |
| DMDM | 3183117 | |
| MaxQB | Q15118 | |
| PaxDb | Q15118 | |
| PRIDE | Q15118 | |
| DNASU | 5163 | |
| Ensembl | ENST00000282077 ENST00000392571 ENST00000410055 | |
| GeneID | 5163 | |
| KEGG | hsa:5163 | |
| UCSC | uc002uhs.3 | |
| CTD | 5163 | |
| GeneCards | GC02P173420 | |
| HGNC | HGNC:8809 | |
| HPA | CAB017554 HPA027376 | |
| MIM | 602524 | |
| neXtProt | NX_Q15118 | |
| PharmGKB | PA33154 | |
| eggNOG | COG0642 | |
| GeneTree | ENSGT00550000074574 | |
| HOGENOM | HOG000164315 | |
| HOVERGEN | HBG000511 | |
| InParanoid | Q15118 | |
| KO | K12077 | |
| OMA | EDAKTIY | |
| OrthoDB | EOG71VSSV | |
| PhylomeDB | Q15118 | |
| TreeFam | TF314918 | |
| Reactome | REACT_12528 | |
| SignaLink | Q15118 | |
| EvolutionaryTrace | Q15118 | |
| GeneWiki | Pyruvate_dehydrogenase_lipoamide_kinase_isozyme_1 | |
| GenomeRNAi | 5163 | |
| NextBio | 19974 | |
| PRO | PR:Q15118 | |
| Proteomes | UP000005640 | |
| Bgee | Q15118 | |
| CleanEx | HS_PDK1 | |
| ExpressionAtlas | Q15118 | |
| Genevestigator | Q15118 | |
| GO | GO:0005759 GO:0005967 GO:0005739 GO:0005524 GO:0004672 GO:0004740 GO:0008283 GO:0044237 GO:0006006 GO:0097411 GO:0008631 GO:0006468 GO:0006090 GO:0010510 GO:0010906 GO:0044281 | |
| Gene3D | 1.20.140.20 3.30.565.10 | |
| InterPro | IPR018955 IPR003594 IPR005467 | |
| Pfam | PF10436 PF02518 | |
| SMART | SM00387 | |
| SUPFAM | SSF55874 SSF69012 | |
| PROSITE | PS50109 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0097411 |
hypoxia-inducible factor-1alpha signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010906 |
regulation of glucose metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008631 |
intrinsic apoptotic signaling pathway in response to oxidative stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004740 |
pyruvate dehydrogenase (acetyl-transferring) kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004740 |
pyruvate dehydrogenase (acetyl-transferring) kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004672 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004672 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004672 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004740 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004740 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004740 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010510 |
regulation of acetyl-CoA biosynthetic process from pyruvate |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BFP9 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005967 |
mitochondrial pyruvate dehydrogenase complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8BFP9 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004740 |
pyruvate dehydrogenase (acetyl-transferring) kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006006 |
glucose metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010510 |
regulation of acetyl-CoA biosynthetic process from pyruvate |
Reactome:R-HSA-204174 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
Reactome:R-HSA-203946 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0005975 |
carbohydrate metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006006 |
glucose metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Lu, CW et al. (2011) Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. Am. J. Pathol. 179 1405-14 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 McFate, T et al. (2008) Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells. J. Biol. Chem. 283 22700-8 PubMed GONUTS page
- ↑ Hitosugi, T et al. (2011) Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol. Cell 44 864-77 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gudi, R et al. (1995) Diversity of the pyruvate dehydrogenase kinase gene family in humans. J. Biol. Chem. 270 28989-94 PubMed GONUTS page
- ↑ Kato, M et al. (2007) Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol. Structure 15 992-1004 PubMed GONUTS page
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