HUMAN:AKT1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	AKT1 (synonyms: PKB, RAC)
Protein Name(s)	RAC-alpha serine/threonine-protein kinase Protein kinase B PKB Protein kinase B alpha PKB alpha Proto-oncogene c-Akt RAC-PK-alpha
External Links
UniProt	P31749
EMBL	M63167 AF283830 AF283819 AF283820 AF283821 AF283822 AF283823 AF283824 AF283825 AF283826 AF283827 AF283828 AF283829 AK299310 AK314256 AB451242 AB451367 AL583722 AL590327 BC000479 BC084538 X61037
CCDS	CCDS9994.1
PIR	A39360
RefSeq	NP_001014431.1 NP_001014432.1 NP_005154.2 XP_005267458.1 XP_011534845.1
UniGene	Hs.525622
PDB	1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1
PDBsum	1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1
ProteinModelPortal	P31749
SMR	P31749
BioGrid	106710
DIP	DIP-24269N
IntAct	P31749
MINT	MINT-203775
STRING	9606.ENSP00000270202
BindingDB	P31749
ChEMBL	CHEMBL3038463
DrugBank	DB00171 DB01169
GuidetoPHARMACOLOGY	1479
PhosphoSite	P31749
BioMuta	AKT1
DMDM	60391226
MaxQB	P31749
PaxDb	P31749
PRIDE	P31749
DNASU	207
Ensembl	ENST00000349310 ENST00000402615 ENST00000407796 ENST00000544168 ENST00000554581 ENST00000554848 ENST00000555528
GeneID	207
KEGG	hsa:207
UCSC	uc001ypk.3
CTD	207
GeneCards	GC14M105235
GeneReviews	AKT1
HGNC	HGNC:391
HPA	CAB003765 HPA002891
MIM	114480 114500 164730 176920 615109
neXtProt	NX_P31749
Orphanet	201 744
PharmGKB	PA24684
eggNOG	COG0515
GeneTree	ENSGT00770000120449
HOGENOM	HOG000233033
HOVERGEN	HBG108317
InParanoid	P31749
KO	K04456
OMA	QDDSMES
PhylomeDB	P31749
TreeFam	TF102004
BRENDA	2.7.11.1
Reactome	REACT_111176 REACT_115662 REACT_12442 REACT_12447 REACT_12477 REACT_12564 REACT_13655 REACT_147867 REACT_15523 REACT_1695 REACT_19290 REACT_19358 REACT_19405 REACT_24915 REACT_25042 REACT_263991 REACT_264178 REACT_355377 REACT_355468 REACT_549 REACT_75829
SignaLink	P31749
ChiTaRS	AKT1
EvolutionaryTrace	P31749
GeneWiki	AKT1
GenomeRNAi	207
NextBio	35479782
PMAP-CutDB	P31749
PRO	PR:P31749
Proteomes	UP000005640
Bgee	P31749
CleanEx	HS_AKT1
ExpressionAtlas	P31749
Genevisible	P31749
GO	GO:0005911 GO:0036064 GO:0005737 GO:0005829 GO:0015630 GO:0005739 GO:0005654 GO:0005634 GO:0005886 GO:0043234 GO:0005819 GO:0071889 GO:0005524 GO:0019899 GO:0042802 GO:0016301 GO:0030235 GO:0005547 GO:0043325 GO:0004672 GO:0004674 GO:0004712 GO:0006924 GO:0007568 GO:0008637 GO:0006915 GO:0007596 GO:0030154 GO:0030030 GO:0008283 GO:0006464 GO:0071364 GO:0097011 GO:0071456 GO:0032869 GO:0071260 GO:0071407 GO:0071380 GO:0035924 GO:0031018 GO:0007173 GO:0097194 GO:0038095 GO:0008543 GO:0007186 GO:0010467 GO:0007281 GO:0042593 GO:0006006 GO:0015758 GO:0005978 GO:0060709 GO:0030212 GO:0006954 GO:0045087 GO:0008286 GO:0048009 GO:0035556 GO:0097193 GO:0060716 GO:0031663 GO:0060644 GO:0001893 GO:0061024 GO:0043066 GO:0010507 GO:0045792 GO:0043154 GO:0010951 GO:2001240 GO:0031999 GO:0046329 GO:1901215 GO:1902176 GO:0010748 GO:0006469 GO:0045861 GO:0090201 GO:0048011 GO:0006809 GO:0046209 GO:0001649 GO:0018105 GO:0032287 GO:0048015 GO:0016310 GO:0030168 GO:0043536 GO:0030307 GO:0032270 GO:0031659 GO:0001938 GO:0090004 GO:0045600 GO:0046326 GO:0010907 GO:0045725 GO:0046889 GO:0045429 GO:0051000 GO:0033138 GO:0032436 GO:1900740 GO:0001934 GO:0051091 GO:0010765 GO:0045944 GO:0045907 GO:0012501 GO:0046777 GO:0030163 GO:0000060 GO:0043491 GO:0006468 GO:0016567 GO:1901976 GO:0030334 GO:0005979 GO:0031641 GO:0010975 GO:0050999 GO:0006417 GO:0034405 GO:0032094 GO:0060416 GO:0009408 GO:1990418 GO:0006979 GO:0070141 GO:0007165 GO:0044281 GO:0051146 GO:0031295 GO:0006367 GO:0006412 GO:0048010
Gene3D	2.30.29.30
InterPro	IPR000961 IPR011009 IPR011993 IPR001849 IPR017892 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00169 PF00069 PF00433
SMART	SM00233 SM00133 SM00220
SUPFAM	SSF56112
PROSITE	PS51285 PS50003 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005886	plasma membrane		ECO:0000314			C		Source: MGI	Missing: reference
	GO:0006924	activated T cell apoptosis		ECO:0000315			P		Source: MGI	Missing: reference
	GO:0007186	G-protein coupled receptor protein signalin...		ECO:0000304			P		Source: ProtInc	Missing: reference
	GO:0009408	response to heat		ECO:0000304			P		Source: ProtInc	Missing: reference
	GO:0004674	protein serine/threonine kinase activity	PMID:1833819^[1]	ECO:0000314			F		Figure 4.	complete
	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	PMID:19203586^[2]	ECO:0000314			F		Figure 3e shows that PHLDA3 represses Akt	complete
involved_in	GO:0002042	cell migration involved in sprouting angiogenesis	PMID:28341552^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000402	negative regulation of lymphocyte migration	PMID:28341552^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618) part_of:(GO:0140052)	Seeded From UniProt	complete
involved_in	GO:1903038	negative regulation of leukocyte cell-cell adhesion	PMID:28341552^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0140052) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	PMID:28341552^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:28341552^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002139) regulates_expression_of:(ENSEMBL:ENSG00000154305) occurs_in:(UBERON:0002331)\|occurs_in:(CL:0002618) regulates_expression_of:(ENSEMBL:ENSG00000154305)	Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	PMID:28341552^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002139) occurs_in:(UBERON:0002331)\|occurs_in:(CL:0002618) part_of:(GO:0140052) part_of:(GO:1903038)\|part_of:(GO:0002042)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:18292230^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31750	P	regulates_expression_of:(ENSEMBL:ENSG00000103266) regulates_o_occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:28386764^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	PMID:18483258^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:29104511^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	PMID:18292230^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9UNE7) part_of:(GO:0032091)	Seeded From UniProt	complete
involved_in	GO:0032091	negative regulation of protein binding	PMID:18292230^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9UNE7) has_regulation_target:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:26514923^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038061	NIK/NF-kappaB signaling	PMID:26514923^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:26514923^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903721	positive regulation of I-kappaB phosphorylation	PMID:26514923^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:26514923^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	PMID:26514923^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	PMID:26514923^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:20878056^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:20878056^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035655	interleukin-18-mediated signaling pathway	PMID:21321938^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	causally_upstream_of:(GO:0048661) occurs_in:(UBERON:0007318)	Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:21321938^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0007318)	Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:21711983^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:10983986^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10983986^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010918	positive regulation of mitochondrial membrane potential	PMID:10983986^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:10983986^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10983986^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:10983986^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016242	negative regulation of macroautophagy	PMID:23778976^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0043276)	Seeded From UniProt	complete
involved_in	GO:0043276	anoikis	PMID:23778976^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	PMID:23778976^[13]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0043276)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:10983986^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:16792529^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0072656	maintenance of protein location in mitochondrion	PMID:23962723^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	PMID:20605787^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P62909) part_of:(GO:0018107) happens_during:(GO:1990090)	Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	PMID:20605787^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032079	positive regulation of endodeoxyribonuclease activity	PMID:20605787^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P23396)	Seeded From UniProt	complete
involved_in	GO:0072655	establishment of protein localization to mitochondrion	PMID:23962723^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:20605787^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P62909)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25190803^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8INB9	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:18221368^[18]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990418	response to insulin-like growth factor stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01314	P		Seeded From UniProt	complete
involved_in	GO:0060416	response to growth hormone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q01314	P		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:20011604^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	PMID:16604263^[20]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	PMID:8940145^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070141	response to UV-A	PMID:18483258^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:19057511^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	PMID:10376603^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046889	positive regulation of lipid biosynthetic process	PMID:8940145^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	PMID:8940145^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	PMID:16814735^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045861	negative regulation of proteolysis	PMID:18387192^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	PMID:16814735^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	PMID:17925406^[26]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	PMID:8940145^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:10376603^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034405	response to fluid shear stress	PMID:10376603^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:16814735^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47196	P		Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47196	P		Seeded From UniProt	complete
involved_in	GO:0031999	negative regulation of fatty acid beta-oxidation	PMID:16814735^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:18483258^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030235	nitric-oxide synthase regulator activity	PMID:10376603^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47196	F		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	PMID:18387192^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010907	positive regulation of glucose metabolic process	PMID:16814735^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010748	negative regulation of long-chain fatty acid import across plasma membrane	PMID:16814735^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:18387192^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	PMID:9373175^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P47196	P		Seeded From UniProt	complete
involved_in	GO:0005979	regulation of glycogen biosynthetic process	PMID:8940145^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:19057511^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31750	P		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	PMID:10102273^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63104	F		Seeded From UniProt	complete
involved_in	GO:0048009	insulin-like growth factor receptor signaling pathway	PMID:8978681^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31750	P		Seeded From UniProt	complete
enables	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding	PMID:19203586^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31750	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:19203586^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:19667065^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	PMID:19934221^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:19203586^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:16139227^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	PMID:20333297^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010975	regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31750	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:8978681^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:23431171^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11994271^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20333297^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19203586^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21045808^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19203586^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P31750	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20333297^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	PMID:19203586^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:16540465^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:11994271^[35]	ECO:0000305	curator inference used in manual assertion	GO:0006468	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10102273^[28]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:O43524) occurs_in:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16540465^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:19667065^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16139227^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11994271^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:19850054^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	PMID:16280327^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[40]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003744 FB:FBgn0010379 MGI:MGI:97601 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAPB18E9.02c RGD:3395 RGD:3399 RGD:61925 RGD:620968 RGD:67383 SGD:S000000201 UniProtKB:O15530 UniProtKB:P31749 UniProtKB:Q15208 UniProtKB:Q9NRM7 UniProtKB:Q9Y2H1	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[40]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87986 PANTHER:PTN000683254 RGD:2081 RGD:3395 RGD:3399 RGD:3668 RGD:61925 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000005460 UniProtKB:A0A1D5PUY5 UniProtKB:P31749 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q05513 UniProtKB:Q05655 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004033 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[40]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003091 FB:FBgn0003744 FB:FBgn0010379 FB:FBgn0260399 FB:FBgn0261854 MGI:MGI:104874 MGI:MGI:2182368 MGI:MGI:87986 MGI:MGI:894676 MGI:MGI:97595 MGI:MGI:97596 MGI:MGI:97599 MGI:MGI:97602 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAC24B11.11c PomBase:SPAC821.12 PomBase:SPAPB18E9.02c PomBase:SPCC576.15c RGD:2081 RGD:2082 RGD:3399 RGD:3668 RGD:620146 RGD:620968 RGD:62390 SGD:S000001248 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000003324 SGD:S000005105 SGD:S000005460 SGD:S000006315 TAIR:locus:2088515 UniProtKB:O15530 UniProtKB:O95835 UniProtKB:P05771 UniProtKB:P17252 UniProtKB:P31749 UniProtKB:P31751 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q04759 UniProtKB:Q05513 UniProtKB:Q05655 UniProtKB:Q09013 UniProtKB:Q15208 UniProtKB:Q16512 UniProtKB:Q16513 UniProtKB:Q96GX5 UniProtKB:Q9NRM7 UniProtKB:Q9XF67 UniProtKB:Q9Y243 UniProtKB:Q9Y2H1 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599 dictyBase:DDB_G0268620	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:17030608^[41]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:14749367^[42]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:14749367^[42]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006924	activation-induced cell death of T cells	PMID:14749367^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:14749367^[42]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14749367^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	PMID:22797923^[43]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:7891724^[44]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P31749	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17554339^[45]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P31749	F		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
involved_in	GO:2000010	positive regulation of protein localization to cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:1901653	cellular response to peptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0097194	execution phase of apoptosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0071380	cellular response to prostaglandin E stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0060716	labyrinthine layer blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0060709	glycogen cell differentiation involved in embryonic placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0051146	striated muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0046622	positive regulation of organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0036294	cellular response to decreased oxygen levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
part_of	GO:0036064	ciliary basal body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	C		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	C		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0032287	peripheral nervous system myelin maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0032094	response to food	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0031641	regulation of myelination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0030163	protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0010975	regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0010765	positive regulation of sodium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0010763	positive regulation of fibroblast migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0008637	apoptotic mitochondrial changes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0007281	germ cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0005977	glycogen metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	F		Seeded From UniProt	complete
involved_in	GO:0001893	maternal placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P31750 ensembl:ENSMUSP00000001780	P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	F		Seeded From UniProt	complete
involved_in	GO:0046329	negative regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0045792	negative regulation of cell size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
enables	GO:0032794	GTPase activating protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	F		Seeded From UniProt	complete
involved_in	GO:0032270	positive regulation of cellular protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0030212	hyaluronan metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0030030	cell projection organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0021510	spinal cord development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0010765	positive regulation of sodium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0006412	translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
involved_in	GO:0005978	glycogen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	F		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P47196 ensembl:ENSRNOP00000038369	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR017892 InterPro:IPR034676 InterPro:IPR039027	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR017441 InterPro:IPR017892	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271 InterPro:IPR017892 InterPro:IPR034676	P		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039027	P		Seeded From UniProt	complete
involved_in	GO:0071901	negative regulation of protein serine/threonine kinase activity	PMID:28386764^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:P49841)	Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	PMID:10958679^[46]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:10570282^[47]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10748004^[48] PMID:10570282^[47] PMID:21432781^[49]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:10376602^[50]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006464	cellular protein modification process	PMID:10570282^[47]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10570282^[47]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:24601882^[51]	ECO:0000315			P		Figure 1C shows a constitutively active Akt1 decreases caspase3 compared to the WT control	complete CACAO 10126
involved_in	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	PMID:10748004^[48]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0100002	negative regulation of protein kinase activity by protein phosphorylation	PMID:21711983^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:P49841)\|has_regulation_target:(UniProtKB:P49840)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21711983^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_direct_input:(UniProtKB:P49841) part_of:(GO:0006469)\|has_direct_input(UniProtKB:P49840) part_of:(GO:0006469)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21711983^[11] PMID:21432781^[49] Reactome:R-NUL-8939977 Reactome:R-NUL-3139045 Reactome:R-HSA-8948757 Reactome:R-HSA-8933446 Reactome:R-HSA-389756 Reactome:R-HSA-377186 Reactome:R-HSA-2400001 Reactome:R-HSA-2399999 Reactome:R-HSA-2399996 Reactome:R-HSA-2399992 Reactome:R-HSA-2399988 Reactome:R-HSA-2399985 Reactome:R-HSA-2399982 Reactome:R-HSA-2399981 Reactome:R-HSA-2399977 Reactome:R-HSA-2399969 Reactome:R-HSA-2399966 Reactome:R-HSA-2399941 Reactome:R-HSA-200143 Reactome:R-HSA-198621 Reactome:R-HSA-198613 Reactome:R-HSA-198611 Reactome:R-HSA-198609 Reactome:R-HSA-198599 Reactome:R-HSA-1358791	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	has_direct_input:(UniProtKB:P49841) part_of:(GO:0100002)\|has_direct_input(UniProtKB:P49840) part_of:(GO:0100002)	Seeded From UniProt	complete
involved_in	GO:0060644	mammary gland epithelial cell differentiation	PMID:21432781^[49]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:16280327^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	PMID:21432781^[49]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21432781^[49]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:21432781^[49]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21432781^[49] Reactome:R-HSA-9603279 Reactome:R-HSA-432110 Reactome:R-HSA-377186 Reactome:R-HSA-2317332 Reactome:R-HSA-2317314 Reactome:R-HSA-2243942 Reactome:R-HSA-2243938 Reactome:R-HSA-2243937 Reactome:R-HSA-2219536 Reactome:R-HSA-202137 Reactome:R-HSA-202111 Reactome:R-HSA-199443 Reactome:R-HSA-198640 Reactome:R-HSA-198270	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21432781^[49]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21432781^[49]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051898	negative regulation of protein kinase B signaling	Reactome:R-HSA-199443	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051186	cofactor metabolic process	Reactome:R-HSA-8978934	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050999	regulation of nitric-oxide synthase activity	Reactome:R-HSA-203615	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045746	negative regulation of Notch signaling pathway	Reactome:R-HSA-9604328	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	Reactome:R-HSA-8849469	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	Reactome:R-HSA-8948757 Reactome:R-HSA-200143 Reactome:R-HSA-199863 Reactome:R-HSA-199839 Reactome:R-HSA-199299 Reactome:R-HSA-199298 Reactome:R-HSA-198621 Reactome:R-HSA-198613 Reactome:R-HSA-198611 Reactome:R-HSA-198609 Reactome:R-HSA-198599	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	Reactome:R-HSA-450604 Reactome:R-HSA-450385	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	Reactome:R-HSA-2317332 Reactome:R-HSA-2317314 Reactome:R-HSA-198270	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	Reactome:R-HSA-389356	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	Reactome:R-HSA-210745	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-3139045 Reactome:R-HSA-9604328 Reactome:R-HSA-9603279 Reactome:R-HSA-8948757 Reactome:R-HSA-8933446 Reactome:R-HSA-8848758 Reactome:R-HSA-8848751 Reactome:R-HSA-6811504 Reactome:R-HSA-6790041 Reactome:R-HSA-450499 Reactome:R-HSA-450490 Reactome:R-HSA-390329 Reactome:R-HSA-389756 Reactome:R-HSA-2400010 Reactome:R-HSA-2400001 Reactome:R-HSA-2399997 Reactome:R-HSA-2399985 Reactome:R-HSA-2399982 Reactome:R-HSA-2399981 Reactome:R-HSA-2399977 Reactome:R-HSA-2399969 Reactome:R-HSA-2399966 Reactome:R-HSA-2399941 Reactome:R-HSA-2317332 Reactome:R-HSA-2243942 Reactome:R-HSA-2219536 Reactome:R-HSA-202137 Reactome:R-HSA-202127 Reactome:R-HSA-202111 Reactome:R-HSA-200143 Reactome:R-HSA-199425 Reactome:R-HSA-198621 Reactome:R-HSA-198613 Reactome:R-HSA-198611 Reactome:R-HSA-198609 Reactome:R-HSA-198599 Reactome:R-HSA-198270 Reactome:R-HSA-1497810 Reactome:R-HSA-1497796 Reactome:R-HSA-1497784 Reactome:R-HSA-1358791	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-8939977 Reactome:R-HSA-6805785 Reactome:R-HSA-6805640 Reactome:R-HSA-3769394 Reactome:R-HSA-2399999 Reactome:R-HSA-2399997 Reactome:R-HSA-2399996 Reactome:R-HSA-2399992 Reactome:R-HSA-2399988 Reactome:R-HSA-211164 Reactome:R-HSA-199863 Reactome:R-HSA-199839 Reactome:R-HSA-199299 Reactome:R-HSA-199298	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0005978	glycogen biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0320	P		Seeded From UniProt	complete
involved_in	GO:0005977	glycogen metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0321	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
involved_in	GO:0008643	carbohydrate transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0762	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0313	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Bellacosa, A et al. (1991) A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254 274-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Kawase, T et al. (2009) PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. Cell 136 535-50 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Luo, C et al. (2017) Identification of a molecular signaling gene-gene regulatory network between GWAS susceptibility genes ADTRP and MIA3/TANGO1 for coronary artery disease. Biochim Biophys Acta Mol Basis Dis 1863 1640-1653 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Dickey, CA et al. (2008) Akt and CHIP coregulate tau degradation through coordinated interactions. Proc. Natl. Acad. Sci. U.S.A. 105 3622-7 PubMed GONUTS page
↑ ^5.0 ^5.1 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 He, YY et al. (2008) UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes. Cancer Res. 68 3752-8 PubMed GONUTS page
↑ Long, Y et al. (2017) ATP2B1 gene Silencing Increases Insulin Sensitivity through Facilitating Akt Activation via the Ca/calmodulin Signaling Pathway and Ca-associated eNOS Activation in Endothelial Cells. Int. J. Biol. Sci. 13 1203-1212 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page
↑ ^9.0 ^9.1 Ajiro, M et al. (2010) Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis. Int. J. Oncol. 37 1085-93 PubMed GONUTS page
↑ ^10.0 ^10.1 Reddy, VS et al. (2011) Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. J. Cell. Physiol. 226 3303-15 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Beaulieu, JM (2012) A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci 37 7-16 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Laine, J et al. (2000) The protooncogene TCL1 is an Akt kinase coactivator. Mol. Cell 6 395-407 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Chen, N & Debnath, J (2013) IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway. Autophagy 9 1214-27 PubMed GONUTS page
↑ Fritzius, T et al. (2006) A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. Biochem. J. 399 9-20 PubMed GONUTS page
↑ ^15.0 ^15.1 McCoy, MK et al. (2014) Hexokinase activity is required for recruitment of parkin to depolarized mitochondria. Hum. Mol. Genet. 23 145-56 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Lee, SB et al. (2010) Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair. J. Biol. Chem. 285 29457-68 PubMed GONUTS page
↑ Martin, D et al. (2014) Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3. J. Biol. Chem. 289 30625-34 PubMed GONUTS page
↑ Mills, RD et al. (2008) Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1). J. Neurochem. 105 18-33 PubMed GONUTS page
↑ Maffucci, T et al. (2009) A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation. PLoS ONE 4 e8285 PubMed GONUTS page
↑ Yu, XR et al. (2006) Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway. Acta Biochim. Biophys. Sin. (Shanghai) 38 241-8 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 Kohn, AD et al. (1996) Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J. Biol. Chem. 271 31372-8 PubMed GONUTS page
↑ ^22.0 ^22.1 Yu, J et al. (2009) PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 28 21-33 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Dimmeler, S et al. (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399 601-5 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 Bouzakri, K et al. (2006) siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 4 89-96 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Ketteler, R et al. (2008) A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. Genome Biol. 9 R64 PubMed GONUTS page
↑ Jensen, M et al. (2007) Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. J. Biol. Chem. 282 35179-86 PubMed GONUTS page
↑ Shaw, M et al. (1997) Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. FEBS Lett. 416 307-11 PubMed GONUTS page
↑ ^28.0 ^28.1 Brunet, A et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96 857-68 PubMed GONUTS page
↑ ^29.0 ^29.1 Alessi, DR et al. (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15 6541-51 PubMed GONUTS page
↑ ^30.0 ^30.1 Polzien, L et al. (2009) Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation. J. Biol. Chem. 284 28004-20 PubMed GONUTS page
↑ Bristow, JM et al. (2009) The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration. J. Cell. Sci. 122 4535-46 PubMed GONUTS page
↑ ^32.0 ^32.1 Enomoto, A et al. (2005) Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev. Cell 9 389-402 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 Mahajan, K et al. (2010) Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS ONE 5 e9646 PubMed GONUTS page
↑ Rokudai, S et al. (2013) MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc. Natl. Acad. Sci. U.S.A. 110 3895-900 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 Kane, S et al. (2002) A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J. Biol. Chem. 277 22115-8 PubMed GONUTS page
↑ Oh, WJ et al. (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 29 3939-51 PubMed GONUTS page
↑ ^37.0 ^37.1 Zhang, X et al. (2006) Kinetic mechanism of AKT/PKB enzyme family. J. Biol. Chem. 281 13949-56 PubMed GONUTS page
↑ Sadanandam, A et al. (2010) Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. Microvasc. Res. 79 1-9 PubMed GONUTS page
↑ ^39.0 ^39.1 Yeh, PY et al. (2006) A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus. J. Biol. Chem. 281 167-75 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Benjamin, D et al. (2006) BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites. Mol. Cell. Biol. 26 9497-507 PubMed GONUTS page
↑ ^42.0 ^42.1 ^42.2 ^42.3 ^42.4 Remy, I & Michnick, SW (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol. Cell. Biol. 24 1493-504 PubMed GONUTS page
↑ Hoxhaj, G et al. (2012) ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125 4662-75 PubMed GONUTS page
↑ Datta, K et al. (1995) AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation. Mol. Cell. Biol. 15 2304-10 PubMed GONUTS page
↑ Li, X et al. (2007) Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 447 1012-6 PubMed GONUTS page
↑ Gabai, VL et al. (2000) Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol. Cell. Biol. 20 6826-36 PubMed GONUTS page
↑ ^47.0 ^47.1 ^47.2 ^47.3 Sotsios, Y et al. (1999) The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J. Immunol. 163 5954-63 PubMed GONUTS page
↑ ^48.0 ^48.1 Madge, LA & Pober, JS (2000) A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. J. Biol. Chem. 275 15458-65 PubMed GONUTS page
↑ ^49.0 ^49.1 ^49.2 ^49.3 ^49.4 ^49.5 ^49.6 ^49.7 ^49.8 Heron-Milhavet, L et al. (2011) Akt1 and Akt2: differentiating the aktion. Histol. Histopathol. 26 651-62 PubMed GONUTS page
↑ Fulton, D et al. (1999) Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399 597-601 PubMed GONUTS page
↑ Deng, W et al. (2014) Protein kinase B (PKB/AKT1) formed signaling complexes with mitochondrial proteins and prevented glycolytic energy dysfunction in cultured cardiomyocytes during ischemia-reperfusion injury. Endocrinology 155 1618-28 PubMed GONUTS page

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[PMID:10983986-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Laine, J et al. (2000) The protooncogene TCL1 is an Akt kinase coactivator. Mol. Cell 6 395-407 PubMed GONUTS page

[PMID:23778976-13] 13.0 ^13.1 ^13.2 Chen, N & Debnath, J (2013) IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway. Autophagy 9 1214-27 PubMed GONUTS page

[PMID:16792529-14] Fritzius, T et al. (2006) A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. Biochem. J. 399 9-20 PubMed GONUTS page

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[PMID:20605787-16] 16.0 ^16.1 ^16.2 ^16.3 Lee, SB et al. (2010) Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair. J. Biol. Chem. 285 29457-68 PubMed GONUTS page

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[PMID:20011604-19] Maffucci, T et al. (2009) A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation. PLoS ONE 4 e8285 PubMed GONUTS page

[PMID:16604263-20] Yu, XR et al. (2006) Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway. Acta Biochim. Biophys. Sin. (Shanghai) 38 241-8 PubMed GONUTS page

[PMID:8940145-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 Kohn, AD et al. (1996) Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J. Biol. Chem. 271 31372-8 PubMed GONUTS page

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[PMID:16814735-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 Bouzakri, K et al. (2006) siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 4 89-96 PubMed GONUTS page

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[PMID:9373175-27] Shaw, M et al. (1997) Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. FEBS Lett. 416 307-11 PubMed GONUTS page

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[PMID:19667065-30] 30.0 ^30.1 Polzien, L et al. (2009) Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation. J. Biol. Chem. 284 28004-20 PubMed GONUTS page

[PMID:19934221-31] Bristow, JM et al. (2009) The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration. J. Cell. Sci. 122 4535-46 PubMed GONUTS page

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[PMID:20333297-33] 33.0 ^33.1 ^33.2 Mahajan, K et al. (2010) Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS ONE 5 e9646 PubMed GONUTS page

[PMID:23431171-34] Rokudai, S et al. (2013) MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc. Natl. Acad. Sci. U.S.A. 110 3895-900 PubMed GONUTS page

[PMID:11994271-35] 35.0 ^35.1 ^35.2 Kane, S et al. (2002) A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J. Biol. Chem. 277 22115-8 PubMed GONUTS page

[PMID:21045808-36] Oh, WJ et al. (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 29 3939-51 PubMed GONUTS page

[PMID:16540465-37] 37.0 ^37.1 Zhang, X et al. (2006) Kinetic mechanism of AKT/PKB enzyme family. J. Biol. Chem. 281 13949-56 PubMed GONUTS page

[PMID:19850054-38] Sadanandam, A et al. (2010) Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. Microvasc. Res. 79 1-9 PubMed GONUTS page

[PMID:16280327-39] 39.0 ^39.1 Yeh, PY et al. (2006) A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus. J. Biol. Chem. 281 167-75 PubMed GONUTS page

[PMID:21873635-40] 40.0 ^40.1 ^40.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17030608-41] Benjamin, D et al. (2006) BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites. Mol. Cell. Biol. 26 9497-507 PubMed GONUTS page

[PMID:14749367-42] 42.0 ^42.1 ^42.2 ^42.3 ^42.4 Remy, I & Michnick, SW (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol. Cell. Biol. 24 1493-504 PubMed GONUTS page

[PMID:22797923-43] Hoxhaj, G et al. (2012) ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125 4662-75 PubMed GONUTS page

[PMID:7891724-44] Datta, K et al. (1995) AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation. Mol. Cell. Biol. 15 2304-10 PubMed GONUTS page

[PMID:17554339-45] Li, X et al. (2007) Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 447 1012-6 PubMed GONUTS page

[PMID:10958679-46] Gabai, VL et al. (2000) Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol. Cell. Biol. 20 6826-36 PubMed GONUTS page

[PMID:10570282-47] 47.0 ^47.1 ^47.2 ^47.3 Sotsios, Y et al. (1999) The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. J. Immunol. 163 5954-63 PubMed GONUTS page

[PMID:10748004-48] 48.0 ^48.1 Madge, LA & Pober, JS (2000) A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. J. Biol. Chem. 275 15458-65 PubMed GONUTS page

[PMID:21432781-49] 49.0 ^49.1 ^49.2 ^49.3 ^49.4 ^49.5 ^49.6 ^49.7 ^49.8 Heron-Milhavet, L et al. (2011) Akt1 and Akt2: differentiating the aktion. Histol. Histopathol. 26 651-62 PubMed GONUTS page

[PMID:10376602-50] Fulton, D et al. (1999) Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399 597-601 PubMed GONUTS page

[PMID:24601882-51] Deng, W et al. (2014) Protein kinase B (PKB/AKT1) formed signaling complexes with mitochondrial proteins and prevented glycolytic energy dysfunction in cultured cardiomyocytes during ischemia-reperfusion injury. Endocrinology 155 1618-28 PubMed GONUTS page

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