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PMID:20011604

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Citation

Maffucci, T, Raimondi, C, Abu-Hayyeh, S, Dominguez, V, Sala, G, Zachary, I and Falasca, M (2009) A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation. PLoS ONE 4:e8285

Abstract

The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including phosphoinositide 3-kinase (PI3K) and phospholipase C (PLC)gamma1. Here we investigated the basic FGF (FGF-2)-mediated activation of these enzymes in human umbilical vein endothelial cells (HUVECs) and defined their role in FGF-2-dependent cellular functions.

Links

PubMed PMC2788267 Online version:10.1371/journal.pone.0008285

Keywords

Capillaries/drug effects; Capillaries/enzymology; Cell Movement/drug effects; Endothelial Cells/cytology; Endothelial Cells/drug effects; Endothelial Cells/enzymology; Enzyme Activation/drug effects; Fibroblast Growth Factor 2/pharmacology; Humans; Neovascularization, Physiologic/drug effects; Phosphatidylinositol 3-Kinases/metabolism; Phospholipase C gamma/metabolism; Phosphorylation/drug effects; Protein Kinase C-alpha/metabolism; Signal Transduction/drug effects; Umbilical Veins/cytology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:FGF2

involved_in

GO:0032958: inositol phosphate biosynthetic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FGF2

involved_in

GO:0010863: positive regulation of phospholipase C activity

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FGF2

involved_in

GO:0051209: release of sequestered calcium ion into cytosol

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FGF2

involved_in

GO:0048598: embryonic morphogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FGF2

involved_in

GO:0045766: positive regulation of angiogenesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FGF2

involved_in

GO:0045765: regulation of angiogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FGF2

involved_in

GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FGF2

involved_in

GO:0043536: positive regulation of blood vessel endothelial cell migration

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FGF2

involved_in

GO:0006661: phosphatidylinositol biosynthetic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:FGF2

involved_in

GO:0042060: wound healing

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KPCA

involved_in

GO:0043536: positive regulation of blood vessel endothelial cell migration

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PLCG1

involved_in

GO:0045766: positive regulation of angiogenesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PLCG1

involved_in

GO:0043536: positive regulation of blood vessel endothelial cell migration

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:AKT1

involved_in

GO:0043536: positive regulation of blood vessel endothelial cell migration

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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