PMID:20011604

Citation	Maffucci, T, Raimondi, C, Abu-Hayyeh, S, Dominguez, V, Sala, G, Zachary, I and Falasca, M (2009) A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation. PLoS ONE 4:e8285
Abstract	The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including phosphoinositide 3-kinase (PI3K) and phospholipase C (PLC)gamma1. Here we investigated the basic FGF (FGF-2)-mediated activation of these enzymes in human umbilical vein endothelial cells (HUVECs) and defined their role in FGF-2-dependent cellular functions.
Links	PubMed PMC2788267 Online version:10.1371/journal.pone.0008285
Keywords	Capillaries/drug effects; Capillaries/enzymology; Cell Movement/drug effects; Endothelial Cells/cytology; Endothelial Cells/drug effects; Endothelial Cells/enzymology; Enzyme Activation/drug effects; Fibroblast Growth Factor 2/pharmacology; Humans; Neovascularization, Physiologic/drug effects; Phosphatidylinositol 3-Kinases/metabolism; Phospholipase C gamma/metabolism; Phosphorylation/drug effects; Protein Kinase C-alpha/metabolism; Signal Transduction/drug effects; Umbilical Veins/cytology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:FGF2	involved_in	GO:0032958: inositol phosphate biosynthetic process	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:FGF2	involved_in	GO:0010863: positive regulation of phospholipase C activity	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:FGF2	involved_in	GO:0051209: release of sequestered calcium ion into cytosol	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:FGF2	involved_in	GO:0048598: embryonic morphogenesis	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
HUMAN:FGF2	involved_in	GO:0045766: positive regulation of angiogenesis	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:FGF2	involved_in	GO:0045765: regulation of angiogenesis	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
HUMAN:FGF2	involved_in	GO:0043552: positive regulation of phosphatidylinositol 3-kinase activity	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:FGF2	involved_in	GO:0043536: positive regulation of blood vessel endothelial cell migration	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:FGF2	involved_in	GO:0006661: phosphatidylinositol biosynthetic process	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:FGF2	involved_in	GO:0042060: wound healing	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
HUMAN:KPCA	involved_in	GO:0043536: positive regulation of blood vessel endothelial cell migration	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:PLCG1	involved_in	GO:0045766: positive regulation of angiogenesis	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:PLCG1	involved_in	GO:0043536: positive regulation of blood vessel endothelial cell migration	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:AKT1	involved_in	GO:0043536: positive regulation of blood vessel endothelial cell migration	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete

References

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