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PMID:1833819
| Citation |
Bellacosa, A, Testa, JR, Staal, SP and Tsichlis, PN (1991) A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254:274-7 |
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| Abstract |
The v-akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of v-akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus. Although Akt is a serine-threonine kinase, part of its regulatory region is similar to the Src homology-2 domain, a structural motif characteristic of cytoplasmic tyrosine kinases that functions in protein-protein interactions. This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways. |
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| Keywords |
Amino Acid Sequence; Animals; Mice; Mink; Mink Cell Focus-Inducing Viruses/genetics; Molecular Sequence Data; Oncogene Protein v-akt; Oncogenes/genetics; Protein Kinases/genetics; Protein-Serine-Threonine Kinases; Protein-Tyrosine Kinases/genetics; Retroviridae Proteins, Oncogenic/genetics; Sequence Homology, Nucleic Acid |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004674: protein serine/threonine kinase activity |
ECO:0000314: |
F |
Figure 4. |
complete | ||||
See also
References
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