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DROME:Q9N6D8

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided. (synonyms: prac (ECO:0000313 with EMBL:AAL56639.1))
Protein Name(s) GH11591p (ECO:0000313 with EMBL:AAL39241.1)

P53 tumor suppressor-like protein (ECO:0000313 with EMBL:AAF61572.1) P53-like regulator of apoptosis and cell cycle (ECO:0000313 with EMBL:AAL56639.1) Transcription factor (ECO:0000313 with EMBL:AAF74277.1) Transcription factor p53 (ECO:0000313 with EMBL:AAF75270.1) p53, isoform A (ECO:0000313 with EMBL:AAF56087.2) p53, isoform C (ECO:0000313 with EMBL:ACZ94989.1)

External Links
UniProt Q9N6D8
EMBL AF224713
AF224714
AE014297
AF244918
AF250918
AF263722
AY069096
AF192555
AE014297
RefSeq NP_001163694.1
NP_996268.1
UniGene Dm.3257
SMR Q9N6D8
IntAct Q9N6D8
MINT MINT-1014674
STRING 7227.FBpp0083753
EnsemblMetazoa FBtr0084359
FBtr0301765
GeneID 2768677
KEGG dme:Dmel_CG33336
UCSC CG33336-RA
CTD 2768677
FlyBase FBgn0039044
KO K10149
GenomeRNAi 2768677
NextBio 848043
Proteomes UP000000803
GO GO:0000785
GO:0005829
GO:0005634
GO:0005667
GO:0003682
GO:0001047
GO:0003684
GO:0003690
GO:0002039
GO:0043565
GO:0003700
GO:0008134
GO:0031624
GO:0031625
GO:0006919
GO:0006915
GO:0008219
GO:0006974
GO:0071480
GO:0009267
GO:0034644
GO:0008340
GO:0030330
GO:0006978
GO:0035234
GO:0008630
GO:0042771
GO:0031571
GO:0043553
GO:0046533
GO:0042992
GO:0000122
GO:0014016
GO:0007405
GO:0048477
GO:0045787
GO:2000685
GO:0040010
GO:0043568
GO:0016239
GO:0040018
GO:0045944
GO:0045893
GO:0007131
GO:0042127
GO:0006282
GO:0043523
GO:0046620
GO:0006357
GO:1990248
GO:0010332
GO:0010212
GO:0009314
GO:0009411
GO:0010165
GO:0042246
Gene3D 2.60.40.720
InterPro IPR008967
IPR012346
IPR024631
IPR011615
IPR002117
PANTHER PTHR11447
Pfam PF00870
PF11619
SUPFAM SSF49417

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0008340

determination of adult lifespan

17686972

IMP: Inferred from Mutant Phenotype

P

Fig 1A demonstrated that pan-neuronal expression of dominant negative Dmp53(DN-Dmp53) extends average lifespan up to 19% comparing to the control flies. Fig 1C and 1D shows that DN-Dmp53 expression in insulin producing cells (IPC) using GAL4 drivers derived from dILP2 promoter region extends lifespan up to 19%.

Missing: reference

GO:0032095

regulation of response to food

17686972

IMP: Inferred from Mutant Phenotype

P

SI Table 2 demonstrates that on standard cornmeal food, the expression of wild-type Dmp53 in IPC reduce the mean lifespan by 13% (see row: IPC Rulifson driver with wt-Dmp53). However, on low calories food, the expression of DN-Dmp53 in IPC increase lifespan by 3% (see row IPC Shen driver low cal), while on high calories food, the expression of DN-Dmp53 in IPC increases lifespan by 13% (see row IPC Shen driver high cal).

Missing: reference

GO:0046628

positive regulation of insulin receptor signaling pathway

17686972

IMP: Inferred from Mutant Phenotype

P

SI Fig 6 illustrates that flies expressing DN-Dmp53 weigh less and gain weight slower in the first ten days after eclosion comparing to controls. Therefore, this indicates that wild type Dmp53 positively regulate of IIS pathway. SI Fig 7 shows that mRNA of dILP2 is 60% reduced in flies expressing DN-Dmp53, therefore IIS pathway activation is reduced and wild type Dmp53 acts as positive regulator of IIS.

Missing: reference

GO:0046628

positive regulation of insulin receptor signaling pathway

17686972

IDA: Inferred from Direct Assay

P

Fig 2A, 2B, 2C, 2D, 2E demonstrate reduction of plasma membrane bound tGPH and increase in cytosolic staining of tGPH, which indicates reduced IIS activity in flies expressing DN-Dmp53 as a result of decreased PI3K activity. Fig 4A & 4B shows increased nuclear dFoxO localization in DN-Dmp53 expressing cells comparing to controls.

Missing: reference

GO:0040010

positive regulation of growth rate

17686972

IMP: Inferred from Mutant Phenotype

P

SI Fig 6 illustrates that flies expressing DN-Dmp53 weigh less and gain weight slower in the first ten days after eclosion comparing to controls. Therefore, this indicates that wild type Dmp53 positively regulate of IIS pathway.

Missing: reference

GO:0040018

positive regulation of multicellular organism growth

17686972

IMP: Inferred from Mutant Phenotype

P

SI Fig 6 illustrates that flies expressing DN-Dmp53 weigh less and gain weight slower in the first ten days after eclosion comparing to controls. Therefore, this indicates that wild type Dmp53 positively regulate of IIS pathway.


Missing: reference

GO:0043568

positive regulation of insulin-like growth factor receptor signaling pathway

17686972

IMP: Inferred from Mutant Phenotype

P

SI Fig 6 illustrates that flies expressing DN-Dmp53 weigh less and gain weight slower in the first ten days after eclosion comparing to controls. Therefore, this indicates that wild type Dmp53 positively regulate of IIS pathway. SI Fig 7 shows that mRNA of dILP2 is 60% reduced in flies expressing DN-Dmp53, therefore IIS pathway activation is reduced and wild type Dmp53 acts as positive regulator of IIS.

Missing: reference

GO:0043568

positive regulation of insulin-like growth factor receptor signaling pathway

17686972

IDA: Inferred from Direct Assay

P

Fig 2A, 2B, 2C, 2D, 2E demonstrate reduction of plasma membrane bound tGPH and increase in cytosolic staining of tGPH, which indicates reduced IIS activity in flies expressing DN-Dmp53 as a result of decreased PI3K activity. Fig 4A & 4B shows increased nuclear dFoxO localization in DN-Dmp53 expressing cells comparing to cytoplasmic localization in controls.

Missing: reference

GO:0014067

negative regulation of phosphoinositide 3-kinase cascade

17686972

IDA: Inferred from Direct Assay

P

Fig 2A, 2B, 2C, 2D, 2E demonstrate reduction of plasma membrane bound tGPH and increase in cytosolic staining of tGPH, which indicates reduced IIS activity in flies expressing DN-Dmp53 as a result of decreased PI3K activity.

Missing: reference

GO:0042992

negative regulation of transcription factor import into nucleus

17686972

IDA: Inferred from Direct Assay

P

Fig 4A & 4B shows increased nuclear dFoxO localization in DN-Dmp53 expressing cells comparing to cytoplasmic localization in controls


Missing: reference

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012346

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008967

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012346

F

complete

GO:0003702

RNA polymerase II transcription factor activity

PMID:11048731[1]

TAS: Traceable Author Statement

F

complete

GO:0005515

protein binding

PMID:14871887[2]

IPI: Inferred from Physical Interaction

UniProtKB:Q9V8P9

F

complete

GO:0005515

protein binding

PMID:15575970[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q7KNM2

F

complete

GO:0005515

protein binding

PMID:17933869[4]

IPI: Inferred from Physical Interaction

FB:FBgn0031820

F

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012346

C

complete

GO:0005634

nucleus

PMID:11048731[1]

IC: Inferred by Curator

GO:0003702

C

complete

GO:0006351

transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008967

P

complete

GO:0006351

transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012346

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012346

P

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

PMID:11048731[1]

TAS: Traceable Author Statement

P

complete

GO:0006915

apoptosis

PMID:10910336[5]

TAS: Traceable Author Statement

P

complete

GO:0006915

apoptosis

PMID:12072176[6]

TAS: Traceable Author Statement

P

complete

GO:0006915

apoptosis

PMID:16079158[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006919

activation of caspase activity

PMID:17310982[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006974

response to DNA damage stimulus

PMID:14532134[9]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006974

response to DNA damage stimulus

PMID:19543366[10]

IDA: Inferred from Direct Assay

P

complete

GO:0007131

reciprocal meiotic recombination

PMID:20522776[11]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008219

cell death

PMID:12672954[12]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008340

determination of adult lifespan

PMID:16303568[13]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008340

determination of adult lifespan

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008630

DNA damage response, signal transduction resulting in induction of apoptosis

PMID:12006672[15]

TAS: Traceable Author Statement

P

complete

GO:0009314

response to radiation

PMID:12672954[12]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0009411

response to UV

PMID:16412438[16]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0010212

response to ionizing radiation

PMID:17933869[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0010552

positive regulation of gene-specific transcription from RNA polymerase II promoter

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0010843

promoter binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011615

F

complete

GO:0030330

DNA damage response, signal transduction by p53 class mediator

PMID:12006672[15]

TAS: Traceable Author Statement

P

complete

GO:0030330

DNA damage response, signal transduction by p53 class mediator

PMID:12072176[6]

TAS: Traceable Author Statement

P

complete

GO:0035234

germ cell programmed cell death

PMID:20838898[17]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0040010

positive regulation of growth rate

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0040018

positive regulation of multicellular organism growth

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042127

regulation of cell proliferation

PMID:21179433[18]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042246

tissue regeneration

PMID:16920621[19]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042771

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

PMID:11063934[20]

TAS: Traceable Author Statement

P

complete

GO:0042771

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

PMID:12935877[21]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042771

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

PMID:16860746[22]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042992

negative regulation of transcription factor import into nucleus

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0043193

positive regulation of gene-specific transcription

PMID:17933869[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0043553

negative regulation of phosphatidylinositol 3-kinase activity

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0043568

positive regulation of insulin-like growth factor receptor signaling pathway

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045787

positive regulation of cell cycle

PMID:16326395[23]

IGI: Inferred from Genetic Interaction

FB:FBgn0019624

P

complete

GO:0046620

regulation of organ growth

PMID:21179433[18]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0048477

oogenesis

PMID:20522776[11]

IGI: Inferred from Genetic Interaction

FB:FBgn0002989

P

complete

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:25453105[24]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001047

core promoter binding

PMID:24265704[25]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001097

TFIIH-class transcription factor binding

PMID:23549790[26]

IPI: Inferred from Physical Interaction

FB:FBgn0261109

F

Seeded From UniProt

complete

GO:0002039

p53 binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002117
InterPro:IPR012346

F

Seeded From UniProt

complete

GO:0003682

chromatin binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

F

Seeded From UniProt

complete

GO:0003684

damaged DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

F

Seeded From UniProt

complete

GO:0003690

double-stranded DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002117
InterPro:IPR008967
InterPro:IPR012346

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:17933869[4]

IPI: Inferred from Physical Interaction

FB:FBgn0031820

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002117
InterPro:IPR012346

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:19153663[27]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005667

transcription factor complex

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

C

Seeded From UniProt

complete

GO:0005829

cytosol

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

C

Seeded From UniProt

complete

GO:0006282

regulation of DNA repair

PMID:14729967[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002117
InterPro:IPR008967
InterPro:IPR012346

P

Seeded From UniProt

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

PMID:11139272[29]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

PMID:25211335[30]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002117

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10910336[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:12072176[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:16079158[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:17310982[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006974

cellular response to DNA damage stimulus

PMID:14532134[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006974

cellular response to DNA damage stimulus

PMID:19543366[10]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0007131

reciprocal meiotic recombination

PMID:20522776[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007405

neuroblast proliferation

PMID:22140513[31]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008134

transcription factor binding

PMID:18549481[32]

IPI: Inferred from Physical Interaction

FB:FBgn0026262

F

Seeded From UniProt

complete

GO:0008219

cell death

PMID:12672954[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:16303568[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:12006672[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:18688282[33]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009267

cellular response to starvation

PMID:18794330[34]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009314

response to radiation

PMID:11139272[29]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0009314

response to radiation

PMID:12672954[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009411

response to UV

PMID:16412438[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010165

response to X-ray

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0010212

response to ionizing radiation

PMID:17933869[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010212

response to ionizing radiation

PMID:24240233[35]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0014016

neuroblast differentiation

PMID:22140513[31]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016239

positive regulation of macroautophagy

PMID:18794330[34]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030330

DNA damage response, signal transduction by p53 class mediator

PMID:12006672[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030330

DNA damage response, signal transduction by p53 class mediator

PMID:12072176[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0031571

mitotic G1 DNA damage checkpoint

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0031624

ubiquitin conjugating enzyme binding

PMID:21205821[36]

IPI: Inferred from Physical Interaction

FB:FBgn0004436

F

Seeded From UniProt

complete

GO:0031625

ubiquitin protein ligase binding

PMID:17170702[37]

IPI: Inferred from Physical Interaction

FB:FBgn0039875

F

Seeded From UniProt

complete

GO:0034644

cellular response to UV

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0035234

ectopic germ cell programmed cell death

PMID:20838898[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040010

positive regulation of growth rate

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040018

positive regulation of multicellular organism growth

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042127

regulation of cell proliferation

PMID:21179433[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042246

tissue regeneration

PMID:16920621[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042594

response to starvation

PMID:25017064[38]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:10778860[39]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:11063934[20]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:12935877[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:16860746[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042992

negative regulation of transcription factor import into nucleus

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043523

regulation of neuron apoptotic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0043553

negative regulation of phosphatidylinositol 3-kinase activity

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

F

Seeded From UniProt

complete

GO:0043568

positive regulation of insulin-like growth factor receptor signaling pathway

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011615

F

Seeded From UniProt

complete

GO:0045787

positive regulation of cell cycle

PMID:16326395[23]

IGI: Inferred from Genetic Interaction

FB:FBgn0019624

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:10778860[39]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:17933869[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:24265704[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000154790

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:17686972[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046533

negative regulation of photoreceptor cell differentiation

PMID:19960025[40]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046620

regulation of organ growth

PMID:21179433[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:20522776[11]

IGI: Inferred from Genetic Interaction

FB:FBgn0002989

P

Seeded From UniProt

complete

GO:0071480

cellular response to gamma radiation

PMID:24265704[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1990248

regulation of transcription from RNA polymerase II promoter in response to DNA damage

PMID:24265704[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000685

positive regulation of cellular response to X-ray

PMID:14729967[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

colocalizes_with

GO:0035327

transcriptionally active chromatin

PMID:19153663[27]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

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  2. Secombe, J & Parkhurst, SM (2004) Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein. J. Biol. Chem. 279 17126-33 PubMed GONUTS page
  3. Stanyon, CA et al. (2004) A Drosophila protein-interaction map centered on cell-cycle regulators. Genome Biol. 5 R96 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Bodai, L et al. (2007) Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level. J. Biol. Chem. 282 36386-93 PubMed GONUTS page
  5. 5.0 5.1 De Laurenzi, V & Melino, G (2000) Apoptosis. The little devil of death. Nature 406 135-6 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Richardson, H & Kumar, S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods 265 21-38 PubMed GONUTS page
  7. 7.0 7.1 McEwen, DG & Peifer, M (2005) Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis. Development 132 3935-46 PubMed GONUTS page
  8. 8.0 8.1 Akdemir, F et al. (2007) p53 directs focused genomic responses in Drosophila. Oncogene 26 5184-93 PubMed GONUTS page
  9. 9.0 9.1 Jassim, OW et al. (2003) Dmp53 protects the Drosophila retina during a developmentally regulated DNA damage response. EMBO J. 22 5622-32 PubMed GONUTS page
  10. 10.0 10.1 Ravi, D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet. 5 e1000527 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 Lu, WJ et al. (2010) Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328 1278-81 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 Sogame, N et al. (2003) Drosophila p53 preserves genomic stability by regulating cell death. Proc. Natl. Acad. Sci. U.S.A. 100 4696-701 PubMed GONUTS page
  13. 13.0 13.1 Bauer, JH et al. (2005) Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15 2063-8 PubMed GONUTS page
  14. 14.00 14.01 14.02 14.03 14.04 14.05 14.06 14.07 14.08 14.09 14.10 14.11 14.12 14.13 Bauer, JH et al. (2007) Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling. Proc. Natl. Acad. Sci. U.S.A. 104 13355-60 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 Gorski, S & Marra, M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol. Genomics 9 59-69 PubMed GONUTS page
  16. 16.0 16.1 Rebollar, E et al. (2006) Role of the p53 homologue from Drosophila melanogaster in the maintenance of histone H3 acetylation and response to UV-light irradiation. FEBS Lett. 580 642-8 PubMed GONUTS page
  17. 17.0 17.1 Bakhrat, A et al. (2010) Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis. Apoptosis 15 1425-34 PubMed GONUTS page
  18. 18.0 18.1 18.2 18.3 Mesquita, D et al. (2010) A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila. PLoS Biol. 8 e1000566 PubMed GONUTS page
  19. 19.0 19.1 Wells, BS et al. (2006) Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr. Biol. 16 1606-15 PubMed GONUTS page
  20. 20.0 20.1 Walworth, NC (2000) Cell-cycle checkpoint kinases: checking in on the cell cycle. Curr. Opin. Cell Biol. 12 697-704 PubMed GONUTS page
  21. 21.0 21.1 Lee, JH et al. (2003) In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. FEBS Lett. 550 5-10 PubMed GONUTS page
  22. 22.0 22.1 Colombani, J et al. (2006) Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage. Curr. Biol. 16 1453-8 PubMed GONUTS page
  23. 23.0 23.1 Mandal, S et al. (2005) Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev. Cell 9 843-54 PubMed GONUTS page
  24. Merlo, P et al. (2014) p53 prevents neurodegeneration by regulating synaptic genes. Proc. Natl. Acad. Sci. U.S.A. 111 18055-60 PubMed GONUTS page
  25. 25.0 25.1 25.2 25.3 Zhang, C et al. (2013) Drosophila UTX coordinates with p53 to regulate ku80 expression in response to DNA damage. PLoS ONE 8 e78652 PubMed GONUTS page
  26. Villicaña, C et al. (2013) The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila. J. Cell. Sci. 126 2502-15 PubMed GONUTS page
  27. 27.0 27.1 Schauer, T et al. (2009) Misregulated RNA Pol II C-terminal domain phosphorylation results in apoptosis. Cell. Mol. Life Sci. 66 909-18 PubMed GONUTS page
  28. 28.0 28.1 Brodsky, MH et al. (2004) Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol. Cell. Biol. 24 1219-31 PubMed GONUTS page
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  32. Bereczki, O et al. (2008) TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. BMC Mol. Biol. 9 57 PubMed GONUTS page
  33. Moon, NS et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet. 4 e1000153 PubMed GONUTS page
  34. 34.0 34.1 Hou, YC et al. (2008) Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis. J. Cell Biol. 182 1127-39 PubMed GONUTS page
  35. Link, N et al. (2013) A p53 enhancer region regulates target genes through chromatin conformations in cis and in trans. Genes Dev. 27 2433-8 PubMed GONUTS page
  36. Chen, S et al. (2011) E2 ligase dRad6 regulates DMP53 turnover in Drosophila. J. Biol. Chem. 286 9020-30 PubMed GONUTS page
  37. Yamasaki, S et al. (2007) Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J. 26 113-22 PubMed GONUTS page
  38. Barrio, L et al. (2014) MicroRNA-mediated regulation of Dp53 in the Drosophila fat body contributes to metabolic adaptation to nutrient deprivation. Cell Rep 8 528-41 PubMed GONUTS page
  39. 39.0 39.1 Brodsky, MH et al. (2000) Drosophila p53 binds a damage response element at the reaper locus. Cell 101 103-13 PubMed GONUTS page
  40. Fan, Y et al. (2010) Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Differ. 17 912-21 PubMed GONUTS page