DROME:Q9N6D8

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	No Information Provided. (synonyms: prac (ECO:0000313 with EMBL:AAL56639.1))
Protein Name(s)	GH11591p (ECO:0000313 with EMBL:AAL39241.1) P53 tumor suppressor-like protein (ECO:0000313 with EMBL:AAF61572.1) P53-like regulator of apoptosis and cell cycle (ECO:0000313 with EMBL:AAL56639.1) Transcription factor (ECO:0000313 with EMBL:AAF74277.1) Transcription factor p53 (ECO:0000313 with EMBL:AAF75270.1) p53, isoform A (ECO:0000313 with EMBL:AAF56087.2) p53, isoform C (ECO:0000313 with EMBL:ACZ94989.1)
External Links
UniProt	Q9N6D8
EMBL	AF224713 AF224714 AE014297 AF244918 AF250918 AF263722 AY069096 AF192555 AE014297
RefSeq	NP_001163694.1 NP_996268.1
UniGene	Dm.3257
SMR	Q9N6D8
IntAct	Q9N6D8
MINT	MINT-1014674
STRING	7227.FBpp0083753
EnsemblMetazoa	FBtr0084359 FBtr0301765
GeneID	2768677
KEGG	dme:Dmel_CG33336
UCSC	CG33336-RA
CTD	2768677
FlyBase	FBgn0039044
KO	K10149
GenomeRNAi	2768677
NextBio	848043
Proteomes	UP000000803
GO	GO:0000785 GO:0005829 GO:0005634 GO:0005667 GO:0003682 GO:0001047 GO:0003684 GO:0003690 GO:0002039 GO:0043565 GO:0003700 GO:0008134 GO:0031624 GO:0031625 GO:0006919 GO:0006915 GO:0008219 GO:0006974 GO:0071480 GO:0009267 GO:0034644 GO:0008340 GO:0030330 GO:0006978 GO:0035234 GO:0008630 GO:0042771 GO:0031571 GO:0043553 GO:0046533 GO:0042992 GO:0000122 GO:0014016 GO:0007405 GO:0048477 GO:0045787 GO:2000685 GO:0040010 GO:0043568 GO:0016239 GO:0040018 GO:0045944 GO:0045893 GO:0007131 GO:0042127 GO:0006282 GO:0043523 GO:0046620 GO:0006357 GO:1990248 GO:0010332 GO:0010212 GO:0009314 GO:0009411 GO:0010165 GO:0042246
Gene3D	2.60.40.720
InterPro	IPR008967 IPR012346 IPR024631 IPR011615 IPR002117
PANTHER	PTHR11447
Pfam	PF00870 PF11619
SUPFAM	SSF49417

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008340	determination of adult lifespan	17686972	ECO:0000315			P		Fig 1A demonstrated that pan-neuronal expression of dominant negative Dmp53(DN-Dmp53) extends average lifespan up to 19% comparing to the control flies. Fig 1C and 1D shows that DN-Dmp53 expression in insulin producing cells (IPC) using GAL4 drivers derived from dILP2 promoter region extends lifespan up to 19%.	Missing: reference
	GO:0032095	regulation of response to food	17686972	ECO:0000315			P		SI Table 2 demonstrates that on standard cornmeal food, the expression of wild-type Dmp53 in IPC reduce the mean lifespan by 13% (see row: IPC Rulifson driver with wt-Dmp53). However, on low calories food, the expression of DN-Dmp53 in IPC increase lifespan by 3% (see row IPC Shen driver low cal), while on high calories food, the expression of DN-Dmp53 in IPC increases lifespan by 13% (see row IPC Shen driver high cal).	Missing: reference
	GO:0046628	positive regulation of insulin receptor signaling pathway	17686972	ECO:0000315			P		SI Fig 6 illustrates that flies expressing DN-Dmp53 weigh less and gain weight slower in the first ten days after eclosion comparing to controls. Therefore, this indicates that wild type Dmp53 positively regulate of IIS pathway. SI Fig 7 shows that mRNA of dILP2 is 60% reduced in flies expressing DN-Dmp53, therefore IIS pathway activation is reduced and wild type Dmp53 acts as positive regulator of IIS.	Missing: reference
	GO:0046628	positive regulation of insulin receptor signaling pathway	17686972	ECO:0000314			P		Fig 2A, 2B, 2C, 2D, 2E demonstrate reduction of plasma membrane bound tGPH and increase in cytosolic staining of tGPH, which indicates reduced IIS activity in flies expressing DN-Dmp53 as a result of decreased PI3K activity. Fig 4A & 4B shows increased nuclear dFoxO localization in DN-Dmp53 expressing cells comparing to controls.	Missing: reference
	GO:0040010	positive regulation of growth rate	17686972	ECO:0000315			P		SI Fig 6 illustrates that flies expressing DN-Dmp53 weigh less and gain weight slower in the first ten days after eclosion comparing to controls. Therefore, this indicates that wild type Dmp53 positively regulate of IIS pathway.	Missing: reference
	GO:0040018	positive regulation of multicellular organism growth	17686972	ECO:0000315			P		SI Fig 6 illustrates that flies expressing DN-Dmp53 weigh less and gain weight slower in the first ten days after eclosion comparing to controls. Therefore, this indicates that wild type Dmp53 positively regulate of IIS pathway.	Missing: reference
	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	17686972	ECO:0000315			P		SI Fig 6 illustrates that flies expressing DN-Dmp53 weigh less and gain weight slower in the first ten days after eclosion comparing to controls. Therefore, this indicates that wild type Dmp53 positively regulate of IIS pathway. SI Fig 7 shows that mRNA of dILP2 is 60% reduced in flies expressing DN-Dmp53, therefore IIS pathway activation is reduced and wild type Dmp53 acts as positive regulator of IIS.	Missing: reference
	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	17686972	ECO:0000314			P		Fig 2A, 2B, 2C, 2D, 2E demonstrate reduction of plasma membrane bound tGPH and increase in cytosolic staining of tGPH, which indicates reduced IIS activity in flies expressing DN-Dmp53 as a result of decreased PI3K activity. Fig 4A & 4B shows increased nuclear dFoxO localization in DN-Dmp53 expressing cells comparing to cytoplasmic localization in controls.	Missing: reference
	GO:0014067	negative regulation of phosphoinositide 3-kinase cascade	17686972	ECO:0000314			P		Fig 2A, 2B, 2C, 2D, 2E demonstrate reduction of plasma membrane bound tGPH and increase in cytosolic staining of tGPH, which indicates reduced IIS activity in flies expressing DN-Dmp53 as a result of decreased PI3K activity.	Missing: reference
	GO:0042992	negative regulation of transcription factor import into nucleus	17686972	ECO:0000314			P		Fig 4A & 4B shows increased nuclear dFoxO localization in DN-Dmp53 expressing cells comparing to cytoplasmic localization in controls	Missing: reference
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17686972^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway	PMID:17686972^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity	PMID:17686972^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:17686972^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q95V55)	Seeded From UniProt	complete
involved_in	GO:0040018	positive regulation of multicellular organism growth	PMID:17686972^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040010	positive regulation of growth rate	PMID:17686972^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:17686972^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:17933869^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17933869^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:17310982^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:17170702^[4]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0039875	F		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:16303568^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:16860746^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042246	tissue regeneration	PMID:16920621^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	PMID:16412438^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:16326395^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0019624	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:16303568^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:16079158^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060785	regulation of apoptosis involved in tissue homeostasis	PMID:25882045^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0010369	chromocenter	PMID:25882045^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:25882045^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:25882045^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990248	regulation of transcription from RNA polymerase II promoter in response to DNA damage	PMID:25882045^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:25453105^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:14532134^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006282	regulation of DNA repair	PMID:14729967^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000685	positive regulation of cellular response to X-ray	PMID:14729967^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:12935877^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	PMID:12672954^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008219	cell death	PMID:12672954^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:25211335^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	PMID:25017064^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:24240233^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001097	TFIIH-class transcription factor complex binding	PMID:23549790^[20]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0261109	F		Seeded From UniProt	complete
involved_in	GO:0014016	neuroblast differentiation	PMID:22140513^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007405	neuroblast proliferation	PMID:22140513^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031624	ubiquitin conjugating enzyme binding	PMID:21205821^[22]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0004436	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10778860^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:10778860^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046620	regulation of organ growth	PMID:21179433^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21179433^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035234	ectopic germ cell programmed cell death	PMID:20838898^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:20522776^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0002989	P		Seeded From UniProt	complete
involved_in	GO:0007131	reciprocal meiotic recombination	PMID:20522776^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046533	negative regulation of photoreceptor cell differentiation	PMID:19960025^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19153663^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0035327	transcriptionally active chromatin	PMID:19153663^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:18794330^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:18794330^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:18688282^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:18549481^[31]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0026262	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011615	F		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	PMID:11139272^[32]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:11139272^[32]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030330	DNA damage response, signal transduction by p53 class mediator	PMID:12072176^[33] PMID:12006672^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:12072176^[33] PMID:10910336^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:12006672^[34]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:11063934^[36]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Bauer, JH et al. (2007) Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling. Proc. Natl. Acad. Sci. U.S.A. 104 13355-60 PubMed GONUTS page
↑ ^2.0 ^2.1 Bodai, L et al. (2007) Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level. J. Biol. Chem. 282 36386-93 PubMed GONUTS page
↑ Akdemir, F et al. (2007) p53 directs focused genomic responses in Drosophila. Oncogene 26 5184-93 PubMed GONUTS page
↑ Yamasaki, S et al. (2007) Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J. 26 113-22 PubMed GONUTS page
↑ ^5.0 ^5.1 Bauer, JH et al. (2005) Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15 2063-8 PubMed GONUTS page
↑ Colombani, J et al. (2006) Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage. Curr. Biol. 16 1453-8 PubMed GONUTS page
↑ Wells, BS et al. (2006) Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr. Biol. 16 1606-15 PubMed GONUTS page
↑ Rebollar, E et al. (2006) Role of the p53 homologue from Drosophila melanogaster in the maintenance of histone H3 acetylation and response to UV-light irradiation. FEBS Lett. 580 642-8 PubMed GONUTS page
↑ Mandal, S et al. (2005) Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev. Cell 9 843-54 PubMed GONUTS page
↑ McEwen, DG & Peifer, M (2005) Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis. Development 132 3935-46 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Zhang, B et al. (2015) The function of Drosophila p53 isoforms in apoptosis. Cell Death Differ. 22 2058-67 PubMed GONUTS page
↑ Merlo, P et al. (2014) p53 prevents neurodegeneration by regulating synaptic genes. Proc. Natl. Acad. Sci. U.S.A. 111 18055-60 PubMed GONUTS page
↑ Jassim, OW et al. (2003) Dmp53 protects the Drosophila retina during a developmentally regulated DNA damage response. EMBO J. 22 5622-32 PubMed GONUTS page
↑ ^14.0 ^14.1 Brodsky, MH et al. (2004) Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol. Cell. Biol. 24 1219-31 PubMed GONUTS page
↑ Lee, JH et al. (2003) In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila. FEBS Lett. 550 5-10 PubMed GONUTS page
↑ ^16.0 ^16.1 Sogame, N et al. (2003) Drosophila p53 preserves genomic stability by regulating cell death. Proc. Natl. Acad. Sci. U.S.A. 100 4696-701 PubMed GONUTS page
↑ Zhang, B et al. (2014) Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells. PLoS Genet. 10 e1004581 PubMed GONUTS page
↑ Barrio, L et al. (2014) MicroRNA-mediated regulation of Dp53 in the Drosophila fat body contributes to metabolic adaptation to nutrient deprivation. Cell Rep 8 528-41 PubMed GONUTS page
↑ Link, N et al. (2013) A p53 enhancer region regulates target genes through chromatin conformations in cis and in trans. Genes Dev. 27 2433-8 PubMed GONUTS page
↑ Villicaña, C et al. (2013) The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila. J. Cell. Sci. 126 2502-15 PubMed GONUTS page
↑ ^21.0 ^21.1 Ouyang, Y et al. (2011) dp53 Restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and cyclin E. PLoS ONE 6 e28098 PubMed GONUTS page
↑ Chen, S et al. (2011) E2 ligase dRad6 regulates DMP53 turnover in Drosophila. J. Biol. Chem. 286 9020-30 PubMed GONUTS page
↑ ^23.0 ^23.1 Brodsky, MH et al. (2000) Drosophila p53 binds a damage response element at the reaper locus. Cell 101 103-13 PubMed GONUTS page
↑ ^24.0 ^24.1 Mesquita, D et al. (2010) A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila. PLoS Biol. 8 e1000566 PubMed GONUTS page
↑ Bakhrat, A et al. (2010) Drosophila Chk2 and p53 proteins induce stage-specific cell death independently during oogenesis. Apoptosis 15 1425-34 PubMed GONUTS page
↑ ^26.0 ^26.1 Lu, WJ et al. (2010) Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328 1278-81 PubMed GONUTS page
↑ Fan, Y et al. (2010) Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Differ. 17 912-21 PubMed GONUTS page
↑ ^28.0 ^28.1 Schauer, T et al. (2009) Misregulated RNA Pol II C-terminal domain phosphorylation results in apoptosis. Cell. Mol. Life Sci. 66 909-18 PubMed GONUTS page
↑ ^29.0 ^29.1 Hou, YC et al. (2008) Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis. J. Cell Biol. 182 1127-39 PubMed GONUTS page
↑ Moon, NS et al. (2008) E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet. 4 e1000153 PubMed GONUTS page
↑ Bereczki, O et al. (2008) TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. BMC Mol. Biol. 9 57 PubMed GONUTS page
↑ ^32.0 ^32.1 Kumar, S (2000) Cell death in the fly comes of age. Cell Death Differ. 7 1021-4 PubMed GONUTS page
↑ ^33.0 ^33.1 Richardson, H & Kumar, S (2002) Death to flies: Drosophila as a model system to study programmed cell death. J. Immunol. Methods 265 21-38 PubMed GONUTS page
↑ ^34.0 ^34.1 Gorski, S & Marra, M (2002) Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila. Physiol. Genomics 9 59-69 PubMed GONUTS page
↑ De Laurenzi, V & Melino, G (2000) Apoptosis. The little devil of death. Nature 406 135-6 PubMed GONUTS page
↑ Walworth, NC (2000) Cell-cycle checkpoint kinases: checking in on the cell cycle. Curr. Opin. Cell Biol. 12 697-704 PubMed GONUTS page

[PMID:17686972-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Bauer, JH et al. (2007) Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling. Proc. Natl. Acad. Sci. U.S.A. 104 13355-60 PubMed GONUTS page

[PMID:17933869-2] 2.0 ^2.1 Bodai, L et al. (2007) Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level. J. Biol. Chem. 282 36386-93 PubMed GONUTS page

[PMID:17310982-3] Akdemir, F et al. (2007) p53 directs focused genomic responses in Drosophila. Oncogene 26 5184-93 PubMed GONUTS page

[PMID:17170702-4] Yamasaki, S et al. (2007) Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J. 26 113-22 PubMed GONUTS page

[PMID:16303568-5] 5.0 ^5.1 Bauer, JH et al. (2005) Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr. Biol. 15 2063-8 PubMed GONUTS page

[PMID:16860746-6] Colombani, J et al. (2006) Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage. Curr. Biol. 16 1453-8 PubMed GONUTS page

[PMID:16920621-7] Wells, BS et al. (2006) Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr. Biol. 16 1606-15 PubMed GONUTS page

[PMID:16412438-8] Rebollar, E et al. (2006) Role of the p53 homologue from Drosophila melanogaster in the maintenance of histone H3 acetylation and response to UV-light irradiation. FEBS Lett. 580 642-8 PubMed GONUTS page

[PMID:16326395-9] Mandal, S et al. (2005) Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev. Cell 9 843-54 PubMed GONUTS page

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