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Category:GO:0003906 ! DNA-(apurinic or apyrimidinic site) endonuclease activity
name: DNA-(apurinic or apyrimidinic site) endonuclease activity
namespace: molecular_function
def: "Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)." [Wikipedia:AP_endonuclease]
comment: Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
synonym: "abasic deoxyendoribonuclease activity" EXACT []
synonym: "AP deoxyendoribonuclease activity" EXACT []
synonym: "apurinic deoxyendoribonuclease activity" EXACT []
synonym: "apurinic/apyrimidinic endodeoxyribonuclease activity" EXACT []
synonym: "apyrimidinic deoxyendoribonuclease activity" EXACT []
synonym: "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT []
synonym: "endonuclease VIII activity" RELATED []
synonym: "UV endonuclease" BROAD []
is_a: GO:0140097 ! catalytic activity, acting on DNA
AmiGO
<GOterm>GO:0003906</GOterm>
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This category has the following 2 subcategories, out of 2 total.
