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CAEEL:APN1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) apn-1
Protein Name(s) DNA-(apurinic or apyrimidinic site) lyase

Apurinic-apyrimidinic endonuclease AP endonuclease

External Links
UniProt Q10002
EMBL Z47812
U40707
PIR JC5235
RefSeq NP_495687.1
UniGene Cel.32771
ProteinModelPortal Q10002
SMR Q10002
STRING 6239.T05H10.2
EnsemblMetazoa T05H10.2
GeneID 174291
KEGG cel:CELE_T05H10.2
UCSC T05H10.2
CTD 174291
WormBase T05H10.2
eggNOG COG0648
GeneTree ENSGT00390000013698
HOGENOM HOG000224893
InParanoid Q10002
KO K10771
OMA ENWWKAV
PhylomeDB Q10002
NextBio 883392
PRO PR:Q10002
Proteomes UP000001940
GO GO:0005739
GO:0005634
GO:0003677
GO:0003906
GO:0008081
GO:0008270
GO:0006284
GO:0000737
Gene3D 3.20.20.150
HAMAP MF_00152
InterPro IPR001719
IPR018246
IPR013022
PANTHER PTHR21445
Pfam PF01261
SMART SM00518
SUPFAM SSF51658
TIGRFAMs TIGR00587
PROSITE PS00729
PS00730
PS00731
PS51432

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006284

base-excision repair

PMID:22819077[1]

ISA: Inferred from Sequence Alignment

UniProtKB:P22936


P

Figure 1 shows C.elegans APN-1 shows homology to Yeast Apn1, which is involved in DNA repair

complete
CACAO 8552

GO:0017005

3'-tyrosyl-DNA phosphodiesterase activity

PMID:22819077[1]

IDA: Inferred from Direct Assay

F

Figure 10C shows that APN-1 exhibits a 3' repair diesterase activity

complete
CACAO 8560

GO:0006284

base-excision repair

PMID:22819077[1]

IDA: Inferred from Direct Assay

P

Figure 10 shows that APN-1 has the ability to repair various DNA lesions

complete
CACAO 8562

GO:0008311

double-stranded DNA 3'-5' exodeoxyribonuclease activity

PMID:22819077[1]

IDA: Inferred from Direct Assay

F

Fig.10C

complete
CACAO 9044

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001719

F

Seeded From UniProt

complete

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.2.99.18

F

Seeded From UniProt

complete

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

PMID:15907773[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000485021

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005739

mitochondrion

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000485021

C

Seeded From UniProt

complete

GO:0006281

DNA repair

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001719

P

Seeded From UniProt

complete

GO:0006281

DNA repair

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

GO:0006284

base-excision repair

PMID:15907773[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006284

base-excision repair

PMID:22819077[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

GO:0008081

phosphoric diester hydrolase activity

PMID:15907773[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001719
InterPro:IPR018246

F

Seeded From UniProt

complete

GO:0008311

double-stranded DNA 3'-5' exodeoxyribonuclease activity

PMID:22819077[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0016829

lyase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

GO:0017005

3'-tyrosyl-DNA phosphodiesterase activity

PMID:22819077[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0090305

nucleic acid phosphodiester bond hydrolysis

PMID:22819077[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Yang, X et al. (2012) Functional characterization of the Caenorhabditis elegans DNA repair enzyme APN-1. DNA Repair (Amst.) 11 811-22 PubMed GONUTS page
  2. 2.0 2.1 2.2 Shatilla, A et al. (2005) Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation. DNA Repair (Amst.) 4 655-70 PubMed GONUTS page