CAEEL:APN1

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	apn-1
Protein Name(s)	DNA-(apurinic or apyrimidinic site) lyase Apurinic-apyrimidinic endonuclease AP endonuclease
External Links
UniProt	Q10002
EMBL	Z47812 U40707
PIR	JC5235
RefSeq	NP_495687.1
UniGene	Cel.32771
ProteinModelPortal	Q10002
SMR	Q10002
STRING	6239.T05H10.2
EnsemblMetazoa	T05H10.2
GeneID	174291
KEGG	cel:CELE_T05H10.2
UCSC	T05H10.2
CTD	174291
WormBase	T05H10.2
eggNOG	COG0648
GeneTree	ENSGT00390000013698
HOGENOM	HOG000224893
InParanoid	Q10002
KO	K10771
OMA	ENWWKAV
PhylomeDB	Q10002
NextBio	883392
PRO	PR:Q10002
Proteomes	UP000001940
GO	GO:0005739 GO:0005634 GO:0003677 GO:0003906 GO:0008081 GO:0008270 GO:0006284 GO:0000737
Gene3D	3.20.20.150
HAMAP	MF_00152
InterPro	IPR001719 IPR018246 IPR013022
PANTHER	PTHR21445
Pfam	PF01261
SMART	SM00518
SUPFAM	SSF51658
TIGRFAMs	TIGR00587
PROSITE	PS00729 PS00730 PS00731 PS51432

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006284	base-excision repair	PMID:22819077	ECO:0000247		UniProtKB:P22936	P		Figure 1 shows C.elegans APN-1 shows homology to Yeast Apn1, which is involved in DNA repair	complete CACAO 8552
	GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	PMID:22819077	ECO:0000314			F		Figure 10C shows that APN-1 exhibits a 3' repair diesterase activity	complete CACAO 8560
	GO:0006284	base-excision repair	PMID:22819077	ECO:0000314			P		Figure 10 shows that APN-1 has the ability to repair various DNA lesions	complete CACAO 8562
	GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity	PMID:22819077	ECO:0000314			F		Fig.10C	complete CACAO 9044
involved_in	GO:0006284	base-excision repair	PMID:22819077	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017005	3'-tyrosyl-DNA phosphodiesterase activity	PMID:22819077	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity	PMID:22819077	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008081	phosphoric diester hydrolase activity	PMID:15907773	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	PMID:15907773	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	PMID:15907773	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008081	phosphoric diester hydrolase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000485019 SGD:S000001597 WB:WBGene00000151	F		Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000485019 SGD:S000001597 WB:WBGene00000151	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000485021 SGD:S000001597	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000485021 SGD:S000001597	C		Seeded From UniProt	complete
enables	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000485019 SGD:S000001597 WB:WBGene00000151	F		Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008311	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001719	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001719	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001719 InterPro:IPR018246	F		Seeded From UniProt	complete
enables	GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.2.99.18	F		Seeded From UniProt	complete
enables	GO:0016829	lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
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References

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