HUMAN:HMGA2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HMGA2 (synonyms: HMGIC)
Protein Name(s)	High mobility group protein HMGI-C High mobility group AT-hook protein 2
External Links
UniProt	P52926
EMBL	Z31595 U28749 U28754 U28750 U28751 U28752 U28753 L46353 L41044 L44578 X92518 AY601861 AY601862 AY601863 AY601864 AY601867 AC090673 AC107308
CCDS	CCDS31854.1 CCDS44936.1
PIR	JC2232
RefSeq	NP_003474.1 NP_003475.1
UniGene	Hs.505924
ProteinModelPortal	P52926
BioGrid	113763
IntAct	P52926
STRING	9606.ENSP00000384026
PhosphoSite	P52926
DMDM	1708263
MaxQB	P52926
PaxDb	P52926
PRIDE	P52926
DNASU	8091
Ensembl	ENST00000354636 ENST00000393578 ENST00000403681 ENST00000425208 ENST00000537275 ENST00000537429
GeneID	8091
KEGG	hsa:8091
UCSC	uc001sst.1 uc001ssv.3 uc001ssx.3
CTD	8091
GeneCards	GC12P066218
HGNC	HGNC:5009
HPA	CAB017809
MIM	150699 600698 611547
neXtProt	NX_P52926
Orphanet	94063 99970 99971
PharmGKB	PA35093
eggNOG	NOG295015
GeneTree	ENSGT00730000111387
HOGENOM	HOG000076308
HOVERGEN	HBG051913
InParanoid	P52926
KO	K09283
OMA	NKGPKTA
OrthoDB	EOG7QRQXW
PhylomeDB	P52926
TreeFam	TF351623
Reactome	REACT_169121
SignaLink	P52926
ChiTaRS	HMGA2
GeneWiki	HMGA2
GenomeRNAi	8091
NextBio	30727
PRO	PR:P52926
Proteomes	UP000005640
Bgee	P52926
CleanEx	HS_HMGA2
ExpressionAtlas	P52926
Genevestigator	P52926
GO	GO:0000228 GO:0005654 GO:0005634 GO:0032993 GO:0035985 GO:0071141 GO:0051575 GO:0003680 GO:0070742 GO:0035497 GO:0001047 GO:0003677 GO:0008301 GO:0003906 GO:0004677 GO:0035501 GO:0035500 GO:0031492 GO:0000975 GO:0001078 GO:0001077 GO:0046332 GO:0008134 GO:0006284 GO:0002062 GO:0035988 GO:0006325 GO:0031052 GO:0030261 GO:0000737 GO:0042769 GO:0035987 GO:0001837 GO:0045444 GO:0031507 GO:0035978 GO:0048762 GO:0048333 GO:0003131 GO:0007095 GO:0007067 GO:0007275 GO:0043922 GO:0043066 GO:0043392 GO:2001033 GO:0045869 GO:0000122 GO:0045892 GO:0090402 GO:0043065 GO:0071158 GO:2000685 GO:2000774 GO:0010628 GO:2001022 GO:2000648 GO:0045944 GO:2000679 GO:0045893 GO:0010564 GO:2001038 GO:0040008 GO:2000036 GO:0006355 GO:0009615 GO:0035986 GO:0048863
InterPro	IPR020478 IPR017956 IPR000116 IPR000637
Pfam	PF02178
PRINTS	PR00929 PR00930
SMART	SM00384
PROSITE	PS00354

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0043392	negative regulation of DNA binding	PMID:19549901^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P13010) negatively_regulates:(GO:0045027)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P52927	F		Seeded From UniProt	complete
involved_in	GO:2000773	negative regulation of cellular senescence	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P52927	P	occurs_in:(CL:0002092)	Seeded From UniProt	complete
involved_in	GO:0071864	positive regulation of cell proliferation in bone marrow	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P52927	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P52927	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16791210^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001038	regulation of cellular response to drug	PMID:16061642^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	PMID:19549901^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001022	positive regulation of response to DNA damage stimulus	PMID:19465398^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001022	positive regulation of response to DNA damage stimulus	PMID:16061642^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000774	positive regulation of cellular senescence	PMID:16901784^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000685	positive regulation of cellular response to X-ray	PMID:16061642^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	PMID:18832382^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000648	positive regulation of stem cell proliferation	PMID:17624332^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000648	positive regulation of stem cell proliferation	PMID:21484705^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000036	regulation of stem cell population maintenance	PMID:17624332^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090402	oncogene-induced cell senescence	PMID:16901784^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071158	positive regulation of cell cycle arrest	PMID:16061642^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0071141	SMAD protein complex	PMID:18832382^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0070742	C2H2 zinc finger domain binding	PMID:14645522^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0051575	5'-deoxyribose-5-phosphate lyase activity	PMID:19465398^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	PMID:17078040^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048762	mesenchymal cell differentiation	PMID:17624332^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048762	mesenchymal cell differentiation	PMID:7606786^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048333	mesodermal cell differentiation	PMID:17624332^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:18832382^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15796	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:18832382^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P84022	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:18832382^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13485	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14645522^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18832382^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17624332^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15755872^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17005673^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15225648^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17324944^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17426251^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:16901784^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18832382^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	PMID:17005673^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	PMID:17624332^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	PMID:7606786^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043922	negative regulation by host of viral transcription	PMID:17005673^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	PMID:14645522^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:19465398^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:16061642^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042769	DNA damage response, detection of DNA damage	PMID:19465398^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035988	chondrocyte proliferation	PMID:21484705^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035987	endodermal cell differentiation	PMID:17624332^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035986	senescence-associated heterochromatin focus assembly	PMID:16901784^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035985	senescence-associated heterochromatin focus	PMID:16901784^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035978	histone H2A-S139 phosphorylation	PMID:16061642^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035501	MH1 domain binding	PMID:18832382^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035500	MH2 domain binding	PMID:18832382^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035497	cAMP response element binding	PMID:14645522^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:19465398^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031507	heterochromatin assembly	PMID:16901784^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031492	nucleosomal DNA binding	PMID:17078040^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031052	chromosome breakage	PMID:19549901^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:18832382^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010564	regulation of cell cycle process	PMID:14645522^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:17005673^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:14627817^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008301	DNA binding, bending	PMID:20108983^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:14645522^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q66K89	F		Seeded From UniProt	complete
involved_in	GO:0007095	mitotic G2 DNA damage checkpoint	PMID:16061642^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:7606786^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	PMID:19465398^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17324944^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17078040^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16901784^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	PMID:19549901^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(GO:0070418) part_of:(GO:2001032)	Seeded From UniProt	complete
enables	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	PMID:19465398^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	PMID:18832382^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	PMID:21533145^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	PMID:17078040^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	PMID:14627817^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	PMID:17426251^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	PMID:20108983^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:8198613^[20]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003131	mesodermal-endodermal cell signaling	PMID:17624332^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	PMID:21484705^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:18832382^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:14627817^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:18832382^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:14627817^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:18832382^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:17426251^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000228	nuclear chromosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P52927	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:14627817^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001155469 UniProtKB:P52926	P		Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001155469 UniProtKB:P17096 UniProtKB:P52926	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101761 MGI:MGI:96160 PANTHER:PTN001155469 RGD:620617 UniProtKB:P17096 UniProtKB:P52926	C		Seeded From UniProt	complete
enables	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001155469 UniProtKB:P17096 UniProtKB:P52926	F		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000116	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000116 InterPro:IPR017956	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000116	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000116 InterPro:IPR000637	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:7606786^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	PMID:7606786^[11] PMID:19551524^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	PMID:7606786^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000036	regulation of stem cell population maintenance	PMID:19551524^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-4647594	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030261	chromosome condensation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0226	P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0341	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Li, AY et al. (2009) Suppression of nonhomologous end joining repair by overexpression of HMGA2. Cancer Res. 69 5699-706 PubMed GONUTS page
↑ Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Boo, LM et al. (2005) High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation. Cancer Res. 65 6622-30 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Summer, H et al. (2009) HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy. Nucleic Acids Res. 37 4371-84 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Narita, M et al. (2006) A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126 503-14 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 Thuault, S et al. (2008) HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J. Biol. Chem. 283 33437-46 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Li, O et al. (2007) DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells. FEBS Lett. 581 3533-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Richter, A et al. (2011) High-mobility group protein HMGA2-derived fragments stimulate the proliferation of chondrocytes and adipose tissue-derived stem cells. Eur Cell Mater 21 355-63 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Tessari, MA et al. (2003) Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Mol. Cell. Biol. 23 9104-16 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Li, O et al. (2006) High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells. Genesis 44 523-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Ashar, HR et al. (1995) Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82 57-65 PubMed GONUTS page
↑ Crombez, KR et al. (2005) Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2. Mol. Cancer Res. 3 63-70 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Shlapobersky, M et al. (2006) Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcription. J. Virol. 80 9951-61 PubMed GONUTS page
↑ Brants, JR et al. (2004) Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. FEBS Lett. 569 277-83 PubMed GONUTS page
↑ ^15.0 ^15.1 Cattaruzzi, G et al. (2007) The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function. Nucleic Acids Res. 35 1751-60 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Cleynen, I et al. (2007) HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB. Mol. Cancer Res. 5 363-72 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Borrmann, L et al. (2003) High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity. Nucleic Acids Res. 31 6841-51 PubMed GONUTS page
↑ ^18.0 ^18.1 Chen, B et al. (2010) DNA bending by the mammalian high-mobility group protein AT hook 2. Biochemistry 49 1590-5 PubMed GONUTS page
↑ Winter, N et al. (2011) Chromatin immunoprecipitation to analyze DNA binding sites of HMGA2. PLoS ONE 6 e18837 PubMed GONUTS page
↑ Patel, UA et al. (1994) Expression and cDNA cloning of human HMGI-C phosphoprotein. Biochem. Biophys. Res. Commun. 201 63-70 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^22.0 ^22.1 Pfannkuche, K et al. (2009) The high mobility group protein HMGA2: a co-regulator of chromatin structure and pluripotency in stem cells? Stem Cell Rev 5 224-30 PubMed GONUTS page

[PMID:19549901-1] 1.0 ^1.1 ^1.2 ^1.3 Li, AY et al. (2009) Suppression of nonhomologous end joining repair by overexpression of HMGA2. Cancer Res. 69 5699-706 PubMed GONUTS page

[PMID:16791210-2] Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page

[PMID:16061642-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Boo, LM et al. (2005) High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation. Cancer Res. 65 6622-30 PubMed GONUTS page

[PMID:19465398-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Summer, H et al. (2009) HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy. Nucleic Acids Res. 37 4371-84 PubMed GONUTS page

[PMID:16901784-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Narita, M et al. (2006) A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126 503-14 PubMed GONUTS page

[PMID:18832382-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 Thuault, S et al. (2008) HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J. Biol. Chem. 283 33437-46 PubMed GONUTS page

[PMID:17624332-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Li, O et al. (2007) DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells. FEBS Lett. 581 3533-7 PubMed GONUTS page

[PMID:21484705-8] 8.0 ^8.1 ^8.2 Richter, A et al. (2011) High-mobility group protein HMGA2-derived fragments stimulate the proliferation of chondrocytes and adipose tissue-derived stem cells. Eur Cell Mater 21 355-63 PubMed GONUTS page

[PMID:14645522-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Tessari, MA et al. (2003) Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Mol. Cell. Biol. 23 9104-16 PubMed GONUTS page

[PMID:17078040-10] 10.0 ^10.1 ^10.2 ^10.3 Li, O et al. (2006) High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells. Genesis 44 523-9 PubMed GONUTS page

[PMID:7606786-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 Ashar, HR et al. (1995) Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82 57-65 PubMed GONUTS page

[PMID:15755872-12] Crombez, KR et al. (2005) Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2. Mol. Cancer Res. 3 63-70 PubMed GONUTS page

[PMID:17005673-13] 13.0 ^13.1 ^13.2 ^13.3 Shlapobersky, M et al. (2006) Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcription. J. Virol. 80 9951-61 PubMed GONUTS page

[PMID:15225648-14] Brants, JR et al. (2004) Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. FEBS Lett. 569 277-83 PubMed GONUTS page

[PMID:17324944-15] 15.0 ^15.1 Cattaruzzi, G et al. (2007) The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function. Nucleic Acids Res. 35 1751-60 PubMed GONUTS page

[PMID:17426251-16] 16.0 ^16.1 ^16.2 Cleynen, I et al. (2007) HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB. Mol. Cancer Res. 5 363-72 PubMed GONUTS page

[PMID:14627817-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Borrmann, L et al. (2003) High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity. Nucleic Acids Res. 31 6841-51 PubMed GONUTS page

[PMID:20108983-18] 18.0 ^18.1 Chen, B et al. (2010) DNA bending by the mammalian high-mobility group protein AT hook 2. Biochemistry 49 1590-5 PubMed GONUTS page

[PMID:21533145-19] Winter, N et al. (2011) Chromatin immunoprecipitation to analyze DNA binding sites of HMGA2. PLoS ONE 6 e18837 PubMed GONUTS page

[PMID:8198613-20] Patel, UA et al. (1994) Expression and cDNA cloning of human HMGI-C phosphoprotein. Biochem. Biophys. Res. Commun. 201 63-70 PubMed GONUTS page

[PMID:21873635-21] 21.0 ^21.1 ^21.2 ^21.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19551524-22] 22.0 ^22.1 Pfannkuche, K et al. (2009) The high mobility group protein HMGA2: a co-regulator of chromatin structure and pluripotency in stem cells? Stem Cell Rev 5 224-30 PubMed GONUTS page

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HUMAN:HMGA2

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