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PMID:8198613
| Citation |
Patel, UA, Bandiera, A, Manfioletti, G, Giancotti, V, Chau, KY and Crane-Robinson, C (1994) Expression and cDNA cloning of human HMGI-C phosphoprotein. Biochem. Biophys. Res. Commun. 201:63-70 |
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| Abstract |
The HMGI family contains three members: I, Y and I-C. HMGI and HMGY are alternative splicings of the same gene and are essential transcription factors at several genetic loci. HMGI-C is transcribed from a different gene and is observed only in highly transformed cells. This work shows that human I-C is present in a more restricted range of cell types than I/Y and is absent from hemopoietic cells, as noted for mouse I-C. However, high expression in a human hepatoma line allowed the cloning of the cDNA and 812 bp of 5'-untranslated, 330 bp of coding and 58 bp of 3'-untranslated DNA were sequenced. The open reading frame showed 4 amino acid substitutions and one additional amino acid when compared to mouse I-C, none of them in the basic DNA binding motifs. |
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| Keywords |
Amino Acid Sequence; Base Sequence; Cell Line; Cloning, Molecular; DNA Primers/chemistry; DNA, Complementary/genetics; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/genetics; Gene Expression; Genes; HMGA2 Protein; High Mobility Group Proteins/genetics; Humans; Molecular Sequence Data; RNA, Messenger/genetics; Sequence Alignment; Sequence Homology, Amino Acid |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0003677: DNA binding |
ECO:0000303: author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
See also
References
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