GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
YEAST:APN1
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | APN1 | |
| Protein Name(s) | DNA-(apurinic or apyrimidinic site) lyase 1
Apurinic-apyrimidinic endonuclease 1 AP endonuclease 1 | |
| External Links | ||
| UniProt | P22936 | |
| EMBL | M33667 S93804 Z28114 BK006944 | |
| PIR | S29871 | |
| RefSeq | NP_012808.1 | |
| ProteinModelPortal | P22936 | |
| SMR | P22936 | |
| BioGrid | 34020 | |
| DIP | DIP-4106N | |
| IntAct | P22936 | |
| MINT | MINT-537191 | |
| STRING | 4932.YKL114C | |
| MaxQB | P22936 | |
| PaxDb | P22936 | |
| PeptideAtlas | P22936 | |
| EnsemblFungi | [example_ID YKL114C] | |
| GeneID | 853746 | |
| KEGG | sce:YKL114C | |
| SGD | S000001597 | |
| eggNOG | COG0648 | |
| GeneTree | ENSGT00390000013698 | |
| HOGENOM | HOG000224893 | |
| InParanoid | P22936 | |
| KO | K10771 | |
| OMA | ENWWKAV | |
| OrthoDB | EOG71VT48 | |
| BioCyc | YEAST:G3O-31899-MONOMER | |
| BRENDA | 4.2.99.18 | |
| NextBio | 974804 | |
| PRO | PR:P22936 | |
| Proteomes | UP000002311 | |
| Genevestigator | P22936 | |
| GO | GO:0005739 GO:0005634 GO:0017005 GO:0003677 GO:0003906 GO:0008311 GO:0008081 GO:0008270 GO:0006284 GO:0000737 GO:0000738 | |
| Gene3D | 3.20.20.150 | |
| HAMAP | MF_00152 | |
| InterPro | IPR001719 IPR018246 IPR013022 | |
| PANTHER | PTHR21445 | |
| Pfam | PF01261 | |
| SMART | SM00518 | |
| SUPFAM | SSF51658 | |
| TIGRFAMs | TIGR00587 | |
| PROSITE | PS00729 PS00730 PS00731 PS51432 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006285 |
base-excision repair, AP site formation |
ECO:0000314 |
P |
Fig.10. Incision activities of purified APN-1 on AP site and oxidized base lesions |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 3 |
complete | |||||
| GO:0008296 |
3'-5'-exodeoxyribonuclease activity |
ECO:0000314 |
F |
Figure 6 |
complete | |||||
| GO:0003906 |
DNA-(apurinic or apyrimidinic site) lyase activity |
ECO:0000314 |
F |
Figure 6A |
complete | |||||
| GO:0004520 |
endodeoxyribonuclease activity |
ECO:0000314 |
F |
Figure 7 |
complete | |||||
| GO:0017005 |
3'-tyrosyl-DNA phosphodiesterase activity |
ECO:0000314 |
F |
Figure 6 |
complete | |||||
|
enables |
GO:0017005 |
3'-tyrosyl-DNA phosphodiesterase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003906 |
DNA-(apurinic or apyrimidinic site) endonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008296 |
3'-5'-exodeoxyribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017005 |
3'-tyrosyl-DNA phosphodiesterase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008311 |
double-stranded DNA 3'-5' exodeoxyribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008081 |
phosphoric diester hydrolase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006284 |
base-excision repair |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003906 |
DNA-(apurinic or apyrimidinic site) endonuclease activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003906 |
DNA-(apurinic or apyrimidinic site) endonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003906 |
DNA-(apurinic or apyrimidinic site) endonuclease activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
|
enables |
GO:0008081 |
phosphoric diester hydrolase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000485019 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006284 |
base-excision repair |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000485019 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000485021 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000485021 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003906 |
DNA-(apurinic or apyrimidinic site) endonuclease activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000485019 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008296 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0090305 |
nucleic acid phosphodiester bond hydrolysis |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008311 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0140078 |
class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016829 |
lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Yang, X et al. (2012) Functional characterization of the Caenorhabditis elegans DNA repair enzyme APN-1. DNA Repair (Amst.) 11 811-22 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Jilani, A et al. (2003) Characterization of two independent amino acid substitutions that disrupt the DNA repair functions of the yeast Apn1. Biochemistry 42 6436-45 PubMed GONUTS page
- ↑ Ramotar, D et al. (1991) Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation. Mol. Cell. Biol. 11 4537-44 PubMed GONUTS page
- ↑ Liu, C et al. (2002) Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1. Proc. Natl. Acad. Sci. U.S.A. 99 14970-5 PubMed GONUTS page
- ↑ Ishchenko, AA et al. (2005) The 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae. Mol. Cell. Biol. 25 6380-90 PubMed GONUTS page
- ↑ Johnson, AW & Demple, B (1988) Yeast DNA diesterase for 3'-fragments of deoxyribose: purification and physical properties of a repair enzyme for oxidative DNA damage. J. Biol. Chem. 263 18009-16 PubMed GONUTS page
- ↑ Wang, Z et al. (1997) Molecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extracts. J. Biol. Chem. 272 24064-71 PubMed GONUTS page
- ↑ Vongsamphanh, R et al. (2001) Pir1p mediates translocation of the yeast Apn1p endonuclease into the mitochondria to maintain genomic stability. Mol. Cell. Biol. 21 1647-55 PubMed GONUTS page
- ↑ Ramotar, D et al. (1993) Intracellular localization of the Apn1 DNA repair enzyme of Saccharomyces cerevisiae. Nuclear transport signals and biological role. J. Biol. Chem. 268 20533-9 PubMed GONUTS page
- ↑ 10.0 10.1 Popoff, SC et al. (1990) Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV. Proc. Natl. Acad. Sci. U.S.A. 87 4193-7 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
3
d
f
s
