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MOUSE:NEIL3

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Neil3
Protein Name(s) Endonuclease 8-like 3

DNA glycosylase FPG2 DNA glycosylase/AP lyase Neil3 Endonuclease VIII-like 3 Nei-like protein 3

External Links
UniProt Q8K203
EMBL AB072931
AK031027
BC024921
BC034753
AB202125
CCDS CCDS22305.1
RefSeq NP_666320.1
UniGene Mm.281749
PDB 3W0F
PDBsum 3W0F
ProteinModelPortal Q8K203
SMR Q8K203
STRING 10090.ENSMUSP00000041909
iPTMnet Q8K203
PhosphoSitePlus Q8K203
EPD Q8K203
PaxDb Q8K203
PeptideAtlas Q8K203
PRIDE Q8K203
Ensembl ENSMUST00000047768
GeneID 234258
KEGG mmu:234258
UCSC uc009lsa.2
uc009lsb.2
CTD 55247
MGI MGI:2384588
eggNOG ENOG410IETI
ENOG410ZE81
GeneTree ENSGT00730000110955
HOGENOM HOG000113754
HOVERGEN HBG052594
InParanoid Q8K203
KO K10569
OMA CFFDSSV
OrthoDB EOG091G038I
PhylomeDB Q8K203
TreeFam TF331502
PRO PR:Q8K203
Proteomes UP000000589
Bgee ENSMUSG00000039396
CleanEx MM_NEIL3
ExpressionAtlas Q8K203
Genevisible Q8K203
GO GO:0005654
GO:0005634
GO:0000405
GO:0003684
GO:0019104
GO:0003906
GO:0003690
GO:0003697
GO:0008270
GO:0006284
GO:0006289
InterPro IPR015886
IPR015887
IPR012319
IPR010979
IPR000214
IPR010666
IPR001876
Pfam PF06831
PF06839
PF00641
SMART SM01232
SM00547
SUPFAM SSF46946
SSF81624
SSF90209
PROSITE PS51068
PS01242
PS51066
PS01358
PS50199

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0019104

DNA N-glycosylase activity

PMID:20185759[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006284

base-excision repair

PMID:20185759[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:16428305[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

PMID:20185759[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

PMID:20185759[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

PMID:20185759[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000405

bubble DNA binding

PMID:20185759[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019104

DNA N-glycosylase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10329
MGI:MGI:1920024
MGI:MGI:2384588
PANTHER:PTN000542974
TAIR:locus:2035195
UniProtKB:Q8TAT5

F

Seeded From UniProt

complete

involved_in

GO:0006284

base-excision repair

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2384588
PANTHER:PTN000542974
UniProtKB:P9WNC3
UniProtKB:Q8TAT5
UniProtKB:Q96FI4

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1920024
MGI:MGI:2384588
PANTHER:PTN001123409
UniProtKB:Q8TAT5
UniProtKB:Q969S2
UniProtKB:Q96FI4

C

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10329
MGI:MGI:2384588
PANTHER:PTN000542974
UniProtKB:Q8TAT5

F

Seeded From UniProt

complete

enables

GO:0019104

DNA N-glycosylase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TAT5

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006284

base-excision repair

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TAT5

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TAT5

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TAT5

C

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TAT5

F

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8TAT5

F

Seeded From UniProt

complete

enables

GO:0019104

DNA N-glycosylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TAT5
ensembl:ENSP00000264596

F

Seeded From UniProt

complete

involved_in

GO:0006284

base-excision repair

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TAT5
ensembl:ENSP00000264596

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TAT5
ensembl:ENSP00000264596

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TAT5
ensembl:ENSP00000264596

C

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TAT5
ensembl:ENSP00000264596

F

Seeded From UniProt

complete

enables

GO:0003697

single-stranded DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8TAT5
ensembl:ENSP00000264596

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010979

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015887

F

Seeded From UniProt

complete

enables

GO:0003684

damaged DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012319
InterPro:IPR015886

F

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000214
InterPro:IPR012319
InterPro:IPR015886
InterPro:IPR015887

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000214
InterPro:IPR015887

P

Seeded From UniProt

complete

involved_in

GO:0006284

base-excision repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012319

P

Seeded From UniProt

complete

involved_in

GO:0006289

nucleotide-excision repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015886

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000214
InterPro:IPR010666
InterPro:IPR012319
InterPro:IPR015886
InterPro:IPR015887

F

Seeded From UniProt

complete

enables

GO:0016799

hydrolase activity, hydrolyzing N-glycosyl compounds

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000214
InterPro:IPR012319
InterPro:IPR015886
InterPro:IPR015887

F

Seeded From UniProt

complete

enables

GO:0140078

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.2.99.18

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511
UniProtKB-KW:KW-0326

P

Seeded From UniProt

complete

enables

GO:0016798

hydrolase activity, acting on glycosyl bonds

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Liu, M et al. (2010) The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 107 4925-30 PubMed GONUTS page
  2. ↑ Torisu, K et al. (2005) Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein. J. Biochem. 138 763-72 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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