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MOUSE:NEIL2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Neil2 (synonyms: Gm1212)
Protein Name(s) Endonuclease 8-like 2

DNA glycosylase/AP lyase Neil2 DNA-(apurinic or apyrimidinic site) lyase Neil2 Endonuclease VIII-like 2 Nei homolog 2 NEH2 Nei-like protein 2

External Links
UniProt Q6R2P8
EMBL AY518221
AC090654
CH466535
CCDS CCDS36949.1
RefSeq NP_963904.2
XP_006519262.1
UniGene Mm.239490
ProteinModelPortal Q6R2P8
SMR Q6R2P8
BioGrid 238543
STRING 10090.ENSMUSP00000045200
PhosphoSite Q6R2P8
EPD Q6R2P8
MaxQB Q6R2P8
PaxDb Q6R2P8
PRIDE Q6R2P8
Ensembl ENSMUST00000038229
GeneID 382913
KEGG mmu:382913
UCSC uc007uhk.1
CTD 252969
MGI MGI:2686058
eggNOG ENOG410IJ89
ENOG4112BNS
GeneTree ENSGT00730000110955
HOGENOM HOG000069913
HOVERGEN HBG082014
InParanoid Q6R2P8
KO K10568
OMA SVRKFHH
OrthoDB EOG7Z69CR
TreeFam TF331502
Reactome R-MMU-110329
NextBio 403564
PRO PR:Q6R2P8
Proteomes UP000000589
CleanEx MM_NEIL2
GO GO:0005737
GO:0015630
GO:0005634
GO:0003684
GO:0003906
GO:0016799
GO:0008017
GO:0008270
GO:0006284
GO:0006289
InterPro IPR015886
IPR012319
IPR010979
IPR000214
Pfam PF06831
SUPFAM SSF46946
PROSITE PS51068
PS51066

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032300

mismatch repair complex

PMID:21169365[1]

ECO:0000314

C

Figure 4A

complete
CACAO 11774

enables

GO:0019104

DNA N-glycosylase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10329
MGI:MGI:1920024
MGI:MGI:2384588
PANTHER:PTN000542974
TAIR:locus:2035195
UniProtKB:Q8TAT5

F

Seeded From UniProt

complete

involved_in

GO:0006284

base-excision repair

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2384588
PANTHER:PTN000542974
UniProtKB:P9WNC3
UniProtKB:Q8TAT5
UniProtKB:Q96FI4

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1920024
MGI:MGI:2384588
PANTHER:PTN001123409
UniProtKB:Q8TAT5
UniProtKB:Q969S2
UniProtKB:Q96FI4

C

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10329
MGI:MGI:2384588
PANTHER:PTN000542974
UniProtKB:Q8TAT5

F

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q969S2

C

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

PMID:15725623[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

PMID:15725623[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

colocalizes_with

GO:0005876

spindle microtubule

PMID:15725623[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15725623[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q969S2

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q969S2

C

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q969S2
ensembl:ENSP00000284503

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q969S2
ensembl:ENSP00000284503

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q969S2
ensembl:ENSP00000284503

C

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024R361
ensembl:ENSP00000284503

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024R361
ensembl:ENSP00000284503

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024R361
ensembl:ENSP00000284503

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010979

F

Seeded From UniProt

complete

enables

GO:0003684

damaged DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012319
InterPro:IPR015886

F

Seeded From UniProt

complete

enables

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000214
InterPro:IPR012319
InterPro:IPR015886

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000214

P

Seeded From UniProt

complete

involved_in

GO:0006284

base-excision repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012319

P

Seeded From UniProt

complete

involved_in

GO:0006289

nucleotide-excision repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015886

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000214
InterPro:IPR012319
InterPro:IPR015886

F

Seeded From UniProt

complete

enables

GO:0016799

hydrolase activity, hydrolyzing N-glycosyl compounds

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000214
InterPro:IPR012319
InterPro:IPR015886

F

Seeded From UniProt

complete

enables

GO:0140078

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.2.99.18

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

enables

GO:0016798

hydrolase activity, acting on glycosyl bonds

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0326
UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Banerjee, D et al. (2011) Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. J. Biol. Chem. 286 6006-16 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Conlon, KA et al. (2005) The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro. DNA Repair (Amst.) 4 419-31 PubMed GONUTS page
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